Isolated creatine kinase-MB rise with normal cardiac troponins

2011 ◽  
Vol 12 (10) ◽  
pp. 736-740 ◽  
Author(s):  
Fabrizio Ricci ◽  
Raffaele De Caterina
Keyword(s):  
Creatine Kinase ◽  
Creatine Kinase Mb ◽  
Cardiac Troponins

Analysis of cardiac troponins and creatine kinase MB in cerebrospinal fluid in medicolegal autopsy cases

2009 ◽  
Vol 11 ◽  
pp. S266-S268 ◽  
Author(s):  
Hitoshi Maeda ◽  
Tomomi Michiue ◽  
Bao-Li Zhu ◽  
Takaki Ishikawa ◽  
Li Quan
Keyword(s):  
Cerebrospinal Fluid ◽  
Creatine Kinase ◽  
Creatine Kinase Mb ◽  
Medicolegal Autopsy ◽  
Cardiac Troponins

scholarly journals Evaluating the use of biomarkers for the diagnosis of myocardial injury in neonates

2021 ◽  
pp. 15-20
Author(s):  
Nikhila Butani ◽  
Tapas Mondal
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Sensitivity And Specificity ◽  
Myocardial Injury ◽  
Diagnostic Tools ◽  
Diagnostic Strategies ◽  
Creatine Kinase Mb ◽  
Cardiac Troponins

Myocardial infarction is defined as the obstruction of blood flow to the heart, resulting in oxygen deprivation. While myocardial infarction in adults is common and has sufficient diagnostic strategies, there remain gaps in the diagnostic strategies for myocardial infarction in neonates. Presently, biomarkers such as creatine-kinase MB, brain natriuretic peptide, myoglobin, and troponin are believed to be potential diagnostic tools for neonatal myocardial infarction. This literature review explores the efficacy of biomarkers for early diagnosis of neonatal myocardial infarction. The review concludes that creatine-kinase MB, brain natriuretic peptide, and myoglobin do not serve as accurate biomarkers for myocardial infarction in neonates. However, cardiac troponins, in particular cardiac troponin I, have high sensitivity and specificity for diagnosing myocardial injury. Cardiac troponins experience rapid elevation upon myocardial injury, and they remain unaffected by gestational age and birth weight. In addition, they do not cross the placenta and are therefore intrinsic to the neonate. Future research should be conducted to verify the accuracy, sensitivity, and specificity of cardiac troponins as myocardial infarction biomarkers.  

scholarly journals Chest pain management: use of troponins in internal medicine wards

Diagnosis ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Alfonso Ilardi ◽  
Giuseppe Caruso ◽  
Ciro Rosario Ilardi ◽  
Maria D’Avino
Keyword(s):  
Internal Medicine ◽  
Creatine Kinase ◽  
Chest Pain ◽  
Gold Standard ◽  
Campania Region ◽  
Hospital Size ◽  
Creatine Kinase Mb ◽  
Internal Medicine Wards ◽  
Hospital Doctors ◽  
Cardiac Troponins

AbstractObjectivesTo probe the reference biomarkers used to manage chest pain (CP) by Italian internists.MethodsTwo hundred and fifty-seven doctors registered as members of the Federation of Associations of Hospital Doctors on Internal Medicine of the Campania Region (FADOI-Campania) were surveyed by means of Google Forms platform. Each participant was asked to report his/her sex, age, and location and hospital size (beds in hospital) in which he/she worked. Furthermore, they were asked to indicate the reference biomarker he/she usually employed in the management of patients with CP, choosing from four possible answers. In line with national and international guidelines, cardiac troponins are the gold standard biomarkers.ResultsEighty-two internists (30 females) completed the survey. Interestingly, only 30.5% of participants indicated the cardiac troponins as reference biomarker. Moreover, internists working in medium-sized hospitals appeared to prefer the simultaneous measurement of cardiac troponins and Creatine Kinase MB Isoenzyme.ConclusionsGiven the economic impact of performing inappropriate examinations and the frequency of the CP symptom and associated diseases, rethinking pathways in a multidisciplinary and shared fashion can promote optimization and appropriateness, and therefore stop wastefulness.

Serum Cardiac Troponin T and Creatine Kinase–MB Elevations in Murine Autoimmune Myocarditis

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1927-1932 ◽  
Author(s):  
Kurt Bachmaier ◽  
Johannes Mair ◽  
Felix Offner ◽  
Christian Pummerer ◽  
Nikolaus Neu
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Autoimmune Myocarditis ◽  
Creatine Kinase Mb ◽  
Serum Cardiac Troponin

Modifications in the Concentrations of Circulating Myoglobin after Treatment with Low Doses of Adriamycin

1985 ◽  
Vol 71 (5) ◽  
pp. 463-468 ◽  
Author(s):  
Giovanni Carulli ◽  
Aldo Clerico ◽  
Alessandra Marini ◽  
Maria Grazia Del Chicca ◽  
Renato Vanacore ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Cancer Patients ◽  
Muscle Damage ◽  
Low Doses ◽  
Skeletal Muscle Damage ◽  
Creatine Kinase Mb

The modifications in the concentration of circulating myoglobin have been studied by means of a radioimmunoassay in 15 cancer patients undergoing polychemotherapy including adriamycin. In 8 patients significant increases in myoglobin levels were found after injection of low doses of the drug (25-50 mg/m2). Moreover, a disturbance of the normal biorhythm of the protein was evident in 12 patients. Creatine kinase-MB was evaluated by means of a radioimmunoassay, but there was no relation between an increase in the isoenzyme and an increase in myoglobin. No ECG modifications were detected. These data indicate that the measurement of myoglobin may offer an indication of myocardial or skeletal muscle damage caused by adriamycin.

scholarly journals Interference of ascorbic acid with chemical analytes

2005 ◽  
Vol 42 (6) ◽  
pp. 475-477 ◽  
Author(s):  
Qing H Meng ◽  
William C Irwin ◽  
Jennifer Fesser ◽  
K Lorne Massey
Keyword(s):  
Ascorbic Acid ◽  
Creatine Kinase ◽  
Uric Acid ◽  
Total Cholesterol ◽  
Acid Concentration ◽  
Total Bilirubin ◽  
Binding Capacity ◽  
Ascorbic Acid Concentration ◽  
Sodium Potassium ◽  
Creatine Kinase Mb

Background: Ascorbic acid can interfere with methodologies involving redox reactions, while comprehensive studies on main chemistry analysers have not been reported. We therefore attempted to determine the interference of ascorbic acid with analytes on the Beckman Synchron LX20®. Methods: Various concentrations of ascorbic acid were added to serum, and the serum analytes were measured on the LX20. Results: With a serum ascorbic acid concentration of 12.0 mmol/L, the values for sodium, potassium, calcium and creatinine increased by 43%, 58%, 103% and 26%, respectively ( P<0.01). With a serum ascorbic acid concentration of 12.0 mmol/L, the values for chloride, total bilirubin and uric acid decreased by 33%, 62% and 83%, respectively ( P<0.01), and were undetectable for total cholesterol, triglyceride, ammonia and lactate. There was no definite influence of ascorbic acid on analytical values for total CO2, urea, glucose, phosphate, total protein, albumin, amylase, creatine kinase, creatine kinase-MB, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total iron, unbound iron-binding capacity or magnesium. Conclusions: Ascorbic acid causes a false increase in sodium, potassium, calcium and creatinine results and a false decrease in chloride, total bilirubin, uric acid, total cholesterol, triglyceride, ammonia and lactate results.

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