Second intention healing after wide local excision of soft tissue sarcomas in the distal aspects of the limbs in dogs: 31 cases (2005–2012)

This is the first case report of atypical fibroxanthoma in the otolaryngology literature. Atypical fibroxanthoma is a rare fibrohistiocytic tumor that occurs on actinically damaged skin. The typical presentation is a nodular lesion in sun-exposed areas of the head and neck in an elderly patient. Differentiating atypical fibroxanthoma from other soft tissue sarcomas, such as dermatofibrosarcoma protuberans and malignant fibrous histiocytoma, can be difficult. Treatment should be wide local excision with a 1-cm margin. In cosmetically important regions in which tissue preservation is important, Mohs' surgery should be considered.

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Malignant Granular Cell Tumor of the Back: A Case Report and Review of the Literature

Case Reports in Medicine ◽

10.1155/2014/794648 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 7

Author(s):

Laura Stone McGuire ◽

Danny Yakoub ◽

Mecker G. Möller ◽

Andrew Rosenberg ◽

Alan Livingstone

Keyword(s):

Local Excision ◽

Wide Local Excision ◽

Granular Cell Tumor ◽

Soft Tissue Sarcomas ◽

Granular Cell ◽

Cell Tumor ◽

Phase Iii ◽

Surgical Specimen ◽

Surgery Patient ◽

Malignant Granular Cell Tumor

Malignant granular cell tumors are rare, intensely aggressive entities. This paper presents a case of a large rapidly recurrent malignant granular cell tumor with regional and distal metastases on the back of a 54-year-old Cuban man. The primary tumor recurred within six months of the original wide local excision and with satellite lesions apparent at twelve months, and the mass was diagnosed using the histological criteria established by Fanburg-Smith et al. for malignant granular cell tumors. By fifteen months, right axillary lymphadenopathy, multiple satellite lesions, pulmonary nodules, and distant metastasis in the right thigh were present. At sixteen months, wide local excision of recurrent mass and local satellite masses along with right axillary dissection and placement of Integra with subsequent split-thickness skin graft were performed by surgical oncology and plastic surgery teams. The surgical specimen measured 32.0 × 13.5 × 5.5 cm, containing multiple homogeneous masses with the largest mass 22.0 × 9.0 × 4.6 cm. Following surgery, patient was started on Pazopanib 800 mg/day based on phase III randomized trial data in the treatment of soft tissue sarcomas showing this as a potential novel therapy for malignant granular cell tumors.

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Combined Cutaneous Sarcoma: Pleomorphic Liposarcoma and Conventional Osteosarcoma—The So-Called Malignant Mesenchymoma

Case Reports in Pathology ◽

10.1155/2012/749898 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

David Parada ◽

Karla B. Peña

Keyword(s):

Differential Diagnosis ◽

Soft Tissue ◽

Local Excision ◽

Wide Local Excision ◽

Soft Tissue Tumors ◽

Pleomorphic Liposarcoma ◽

Mesenchymal Origin ◽

Conventional Osteosarcoma ◽

Immunohistochemical Studies

Malignant mesenchymoma is combined soft tissue tumors of mesenchymal origin. Cutaneous combined sarcomas are exceedingly rare. We report the case of an 81-year-old woman who presented a left cutaneous mass. She underwent a wide local excision. Histopathological and immunohistochemical studies were consistent with the diagnosis of combined pleomorphic liposarcoma and conventional osteosarcoma (malignant mesenchymoma). Although it is extremely rare, this case suggests that combined sarcoma should be considered in the differential diagnosis of undifferentiated pleomorphic neoplasms.

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Rare Case of Aggressive Angiomyxoma of the Vulva: A Case Report

Cancer and Clinical Oncology ◽

10.5539/cco.v6n1p8 ◽

2016 ◽

Vol 6 (1) ◽

pp. 8

Author(s):

Gouthaman Shanmugasundaram ◽

Sivasundari Maharajan

Keyword(s):

Soft Tissue ◽

Local Excision ◽

Wide Local Excision ◽

Reproductive Age ◽

Aggressive Angiomyxoma ◽

Soft Tissue Neoplasm ◽

Vascular Component ◽

The Right ◽

Local Examination ◽

Reproductive Age Group

Aggressive Angiomyxoma (AA) is a rare locally aggressive soft tissue tumor with high chance of local recurrence occuring in young women of reproductive age group. These neoplasms are characterized by a mixture of spindle or stellate cells in a loosely myxoid stroma with prominent vascular component containing large, thickwalled blood vessels. A 35 year old multiparous lady presented with right vulval swelling which was rapidly progressing in size. Local examination revealed a soft fleshy mass occupying whole of the right labia majora. In view of the rapidly enlarging lesion over a short duration, we suspected a soft tissue neoplasm and preceded with wide local excision of the mass with adequate margins in all dimensions, eventhough we did not have a preoperative tissue diagnosis. To our surprise, final histopathology was Aggressive Angiomyxoma (AA). The treatment of choice for Aggressive Angiomyxoma is wide local excision with negative margins and the same was done in our case. Recurrence of the tumor may be avoided by wide local excision with adequate margins. It is possibly a hormonally responsive neoplasm. Treatment with Gonadotropin-releasing hormone is an emerging therapy.Overall prognosis of AA is good.

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Postoperative Wound Complications in Fungating Extremity Soft Tissue Sarcomas

Journal of Cancer Biology and Therapeutics ◽

10.18314/gjct.v5i1.1937 ◽

2019 ◽

pp. 273-279

Author(s):

Blakely AM ◽

Chow W ◽

Sampath S ◽

Femino JD ◽

Lozano-Calderon S ◽

...

Keyword(s):

Soft Tissue ◽

Local Excision ◽

Soft Tissue Sarcomas ◽

Wound Complication ◽

Wound Complications ◽

Adjuvant Radiation ◽

Complication Rates ◽

Pleomorphic Sarcoma ◽

Extremity Soft Tissue Sarcoma ◽

Clinically Significant

Background: Among deep extremity soft tissue sarcomas, skin ulceration is infrequent. Fungating sarcomas may lead to infection or clinically significant bleeding. Data regarding management of ulcerating sarcomas is lacking. We sought to evaluate the outcomes of different treatments for these tumors.Patients and methods: A retrospective review of patients treated at two sarcoma referral centers with histologically confirmed extremity soft tissue sarcoma was performed from 2000-2018. Patient demographics, clinicopathologic, and treatment factors were analyzed in terms of method of resection, receipt of radiation, and wound complications.Results: Overall, 22 patients had fungating lesions. Most patients were male with tumors of the distal extremity.Median tumor size was 8 cm. Half had undifferentiated pleomorphic sarcoma histology, followed by myxofibrosarcoma (n=5), leiomyosarcoma (n=3), or other (n=3). Fifteen patients (68%) underwent limb-preserving resection, of which 7 underwent adjuvant radiation. Six patients (27%) developed wound complications, which occurred equally between amputation versus local excision (p = 0.93). Among local excision patients, one who received adjuvant radiation developed a wound complication (14%), which was not significantly different from those who did not undergo radiation (n=3 of 8, 38%; p = 0.31).Conclusions: Similar rates of wound complications were seen between amputation and limb-preserving groups.Among patients who underwent local excision, the administration of adjuvant radiation therapy did not significantly increase wound complication rates.

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