Tumwesigye, N. M.. Wanyenze, R. K. & Greenfield, T. K. (2012). Intoxication before last sexual encounter and HIV risk behavior among men and women in Uganda: Evidence from a nationwide survey. International Journal of Alcohol and Drug Research, 1(1), 67-78. doi: 10.7895/ijadr.v1i1.36 (http://dx.doi.org/10.7895/ijadr.v1i1.36)Aims: To establish the prevalence of intoxication before sex and its association with risky sexual behavior.Design: The data were from the 2006 Uganda Demographic and Health Survey which had been designed for a cross-sectional descriptive study.Setting: The study covered the whole of Uganda.Participants: The respondents were 6,253 women and 1,804 men who had ever had sex.Measurements: The key independent variable was intoxication before last sexual intercourse, while the major outcome variables were condom use and sex with non-regular partners. Weighted prevalence of intoxication was computed and multivariate logistic regression was applied to assess the independent association of intoxication with risky sexual behavior.Findings: Twelve percent of men and 16% of women reported having been intoxicated before last sexual intercourse. Of the women who reported that one of the partners was intoxicated before last sexual intercourse, 78% said it was their partner who was intoxicated. Of the men who reported intoxication, 83% said it was they themselves who were intoxicated. Intoxication of men was associated with having sex with non-regular partners (OR = 1.78, 95% CI: 1.04–3.03) and having unprotected sex (OR = 1.71, 95% CI: 1.07–2.73). Women who were intoxicated were less likely to have been with non-regular partners (OR = 0.55, 95% CI: 0.32–0.95). The women whose partners were intoxicated were more likely to report having had unprotected sex (OR = 1.55, 95% CI: 1.12–2.15).Conclusions: HIV prevention mechanisms should address intoxication before sex. More effort is needed to find ways of helping women avoid unprotected sex with intoxicated partners.