scholarly journals Vector control complements mass drug administration against bancroftian filariasis in Tirukoilur, India

2007 ◽  
Vol 85 (2) ◽  
pp. 138-145 ◽  
Author(s):  
I Sunish
Keyword(s):  
Vector Control ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Bancroftian Filariasis

scholarly journals Lymphatic filariasis, infection status in Culex quinquefasciatus and Anopheles species after six rounds of mass drug administration in Masasi District, Tanzania

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Eliza Lupenza ◽  
Dinah B. Gasarasi ◽  
Omary M. Minzi
Keyword(s):  
Vector Control ◽  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Wuchereria Bancrofti ◽  
Elimination Phase ◽  
Anopheles Species ◽  
The Status ◽  
Household Environment ◽  
Indoor And Outdoor

Abstract Background Lymphatic filariasis (LF) elimination program in Tanzania started in 2000 in response to the Global program for the elimination of LF by 2020. Evidence shows a persistent LF transmission despite more than a decade of mass drug administration (MDA). It is advocated that, regular monitoring should be conducted in endemic areas to evaluate the progress towards elimination and detect resurgence of the disease timely. This study was therefore designed to assess the status of Wuchereria bancrofti infection in Culex quinqefasciatus and Anopheles species after six rounds of MDA in Masasi District, South Eastern Tanzania. Methods Mosquitoes were collected between June and July 2019 using Center for Diseases Control (CDC) light traps and gravid traps for indoor and outdoor respectively. The collected mosquitoes were morphologically identified into respective species. Dissections and PCR were carried out to detect W. bancrofti infection. Questionnaire survey and checklist were used to assess vector control interventions and household environment respectively. A Poisson regression model was run to determine the effects of household environment on filarial vector density. Results Overall, 12 452 mosquitoes were collected of which 10 545 (84.7%) were filarial vectors. Of these, Anopheles gambiae complex, An. funestus group and Cx. quinquefasciatus accounted for 0.1%, 0.7% and 99.2% respectively. A total of 365 pools of Cx. quinquefasciatus (each with 20 mosquitoes) and 46 individual samples of Anopheles species were analyzed by PCR. For Cx. quinquefasciatus pools, 33 were positive for W. bancrofti, giving an infection rate of 0.5%, while the 46 samples of Anopheles species were all negative. All 1859 dissected mosquitoes analyzed by microscopy were also negative. Households with modern latrines had less mosquitoes than those with pit latrines [odds ratio (OR) = 0.407, P < 0.05]. Houses with unscreened windows had more mosquitoes as compared to those with screened windows (OR = 2.125, P < 0.05). More than 80% of the participants own bednets while 16.5% had no protection. Conclusions LF low transmission is still ongoing in Masasi District after six rounds of MDA and vector control interventions. The findings also suggest that molecular tools may be essential for xenomonitoring LF transmission during elimination phase.

Is the coverage of mass-drug-administration adequate for elimination of Bancroftian filariasis? An experience from West Bengal, India

2015 ◽  
Vol 5 (2) ◽  
pp. 106
Author(s):  
Dibakar Haldar ◽  
Dhruba Mandal ◽  
Abhik Sinha ◽  
GautamNarayan Sarkar ◽  
Sucharita Sarkar ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
West Bengal ◽  
Bancroftian Filariasis

scholarly journals Optimising systemic insecticide use to improve malaria control

2019 ◽  
Vol 4 (6) ◽  
pp. e001776 ◽  
Author(s):  
Hannah R Meredith ◽  
Luis Furuya-Kanamori ◽  
Laith Yakob
Keyword(s):  
Vector Control ◽  
Malaria Transmission ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Companion Animals ◽  
Malaria Vectors ◽  
Systemic Insecticide ◽  
Blood Concentrations ◽  
Systemic Insecticides ◽  
The Impact

BackgroundLong-lasting insecticidal nets and indoor residual sprays have significantly reduced the burden of malaria. However, several hurdles remain before elimination can be achieved: mosquito vectors have developed resistance to public health insecticides, including pyrethroids, and have altered their biting behaviour to avoid these indoor control tools. Systemic insecticides, drugs applied directly to blood hosts to kill mosquitoes that take a blood meal, offer a promising vector control option. To date, most studies focus on repurposing ivermectin, a drug used extensively to treat river blindness. There is concern that overdependence on a single drug will inevitably repeat past experiences with the rapid spread of pyrethroid resistance in malaria vectors. Diversifying the arsenal of systemic insecticides used for mass drug administration would improve this strategy’s sustainability.MethodsHere, a review was conducted to identify systemic insecticide candidates and consolidate their pharmacokinetic/pharmacodynamic properties. The impact of alternative integrated vector control options and different dosing regimens on malaria transmission reduction are illustrated through mathematical model simulation.ResultsThe review identified drugs from four classes commonly used in livestock and companion animals: avermectins, milbemycins, isoxazolines and spinosyns. Simulations predicted that isoxazolines and spinosyns are promising candidates for mass drug administration, as they were predicted to need less frequent application than avermectins and milbemycins to maintain mosquitocidal blood concentrations.ConclusionsThese findings will provide a guide for investigating and applying different systemic insecticides to achieve more effective and sustainable control of malaria transmission.

Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment

The Lancet ◽  
2006 ◽  
Vol 367 (9515) ◽  
pp. 992-999 ◽  
Author(s):  
Reda MR Ramzy ◽  
Maged El Setouhy ◽  
Hanan Helmy ◽  
Ehab S Ahmed ◽  
Khaled M Abd Elaziz ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Comprehensive Assessment ◽  
Bancroftian Filariasis

Current WHO protocols for mass drug administration in helminth control

2016 ◽  
Vol 37 (1) ◽  
pp. 10
Author(s):  
Richard S Bradbury ◽  
Patricia M Graves
Keyword(s):  
Vector Control ◽  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Target Population ◽  
Preventive Chemotherapy ◽  
Soil Transmitted Helminths ◽  
Helminth Infections ◽  
The World ◽  
Control Criteria

Soil transmitted helminths (STH), comprising Ascaris, Trichuris, Strongyloides and the hookworms remain a significant cause of morbidity amongst people in many parts of the world, including Australia. Other important helminth infections include lymphatic filariasis (LF), schistosomiasis and onchocerciasis. Preventive chemotherapy (mass drug administration [MDA]) campaigns are frequently conducted for these helminth infections in endemic areas, but the target population groups, duration of campaigns, cointerventions (e.g. vector control) criteria for inclusion, drugs used and doses of drugs differ.

scholarly journals The Impact of Repeated Rounds of Mass Drug Administration with Diethylcarbamazine Plus Albendazole on Bancroftian Filariasis in Papua New Guinea

2008 ◽  
Vol 2 (12) ◽  
pp. e344 ◽  
Author(s):  
Gary J. Weil ◽  
Will Kastens ◽  
Melinda Susapu ◽  
Sandra J. Laney ◽  
Steven A. Williams ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
New Guinea ◽  
Bancroftian Filariasis ◽  
The Impact
Sign in / Sign up

Export Citation Format

Share Document