A Peculiar Case of Cutaneous Eyelid Melanoma: Clinicopathological Questions and Therapeutic Challenges

AbstractPrimary melanoma of the eyelid is a rare malignant tumour that accounts for <1% of all malignant melanomas and about 1% of malignant tumours of the eyelid. The most common clinical presentation of melanoma is an oval lesion; linear presentation is uncommon. We presented a 79-year-old woman with a several-month history of a rapidly-growing, irregular, linear, pigmented cutaneous lesion on the right lower eyelid, involving the eyelid margin. The lesion measured 2 cm x 0,8 cm x 0,2 cm. Anterior and posterior segments appeared normal in both eyes, without pathological findings on ocular ultrasound examination. After excision biopsy, histopathological examination revealed a nodular melanoma. The case underwent additional investigations for staging and therapy. The current therapeutic strategies in eyelid melanoma include surgical excision, systemic chemotherapy, immunotherapy, targeted therapy or radiotherapy. Despite advanced research methods in the field, the management of eyelid melanoma is still a major challenge.

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HISTOPATHOLOGICALANALYSIS OF TUMOURS AND TUMOUR-LIKE LESIONS OF COLON AND RECTUM

10.36106/ijsr/2538967 ◽

2021 ◽

pp. 9-11

Author(s):

Durga Nand Jha ◽

Hari Shankar Mishra ◽

Ajit Kumar Chaudhary ◽

Debarshi Jana

Keyword(s):

Histopathological Examination ◽

Correct Diagnosis ◽

Malignant Tumour ◽

Juvenile Polyp ◽

Tubular Adenoma ◽

Malignant Tumours ◽

Cross Sectional ◽

Colorectal Biopsies ◽

Colon And Rectum ◽

Benign Tumours

Background:Tumours and tumour like lesions of the colon and rectum have overlapping clinical presentation and may be difcult to diagnose on clinical grounds alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be difcult and may require ancillary tests such as immunohistochemistry. Materials and Methods: A prospective cross sectional study enrolled 125 cases of colorectal biopsies after histopathological conrmation of tumours and tumour like lesions. The specimens were received at the Department of Pathology, DMCH, Laheriasarai, Bihar from December 2019 to November 2020. Results: Out of 125 cases, 32 cases were benign tumours, 36 cases were malignant tumours and 57 cases were tumour like lesions. Most common age range was 51-60 years with mean age of 38 years. Males comprised 76.74% and females 23.26% with ratio of 3:1. Juvenile polyp was the commonest lesion. Among benign tumours, tubular adenoma was the most common (19.2%), adenocarcinoma was most common malignant tumour (25.6%) and juvenile polyp was the most common tumour like lesion (27.2%). Left side was most common side (66.67%) and rectum was the most common site (48.8%). Conclusions: The commonest indications for colorectal biopsies were tumours and tumour like lesions. Juvenile polyp was the most common tumour like lesion, tubular adenoma was the most common benign tumour and adenocarcinoma was the most common malignant tumour. Histopathological examination is a gold standard for conrmation of all tumour and tumours like lesions of colon and rectum.

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A histopathological review of nephrectomy specimens with an emphasis on pathological assessment of prognostic indicators in malignant lesions

Biomedicine ◽

10.51248/.v40i4.327 ◽

2021 ◽

Vol 40 (4) ◽

pp. 492-501

Author(s):

Shubha P. Bhat ◽

Krishna Prasad H.V. ◽

Rajeev T.P. ◽

Kishan Prasad H.L. ◽

Teerthanath Srinivas ◽

...

Keyword(s):

Histopathological Examination ◽

Malignant Tumour ◽

Prognostic Indicators ◽

Wilms Tumour ◽

Malignant Tumours ◽

Neoplastic Lesions ◽

Kidney Lesion ◽

Microscopic Features ◽

Malignant Lesions ◽

Pathological Assessment

Introduction and Aim: Various non-neoplastic and neoplastic lesions occur in the kidney. Pathological assessment of gross and microscopic features in nephrectomy specimens is essential for diagnosis and predicts the prognosis in malignant tumours. Materials and Methods: Case records of 46 nephrectomy specimens received between two-year periods were retrieved. Detailed gross and histopathological and immunohistochemical features were studied, and malignant tumours were analysed using CAP protocol. Results: Out of 46 nephrectomy specimens, 17 were non-neoplastic and 29 neoplastic. Males constituted 32 cases and females 14 cases. The commonest non-neoplastic kidney lesion was chronic pyelonephritis with hydronephrosis (29%). The mixed epithelial and stromal tumour was the frequently encountered benign tumour (50%). Renal cell carcinoma was the most common malignant tumour in adults (70%) and Wilms tumour in children (4%). Conclusion: Histopathological examination of nephrectomy specimens helps in diagnosing, staging, and planning the management.

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Histopathological analysis of tumours and tumour-like lesions of colon and rectum

Journal of Pathology of Nepal ◽

10.3126/jpn.v10i1.28747 ◽

2020 ◽

Vol 10 (1) ◽

pp. 1654-1658

Author(s):

Pramila Vaidhya ◽

Ram Chandra Adhikari ◽

Anil Dev Pant

Keyword(s):

Histopathological Examination ◽

Correct Diagnosis ◽

Malignant Tumour ◽

Juvenile Polyp ◽

Histopathological Analysis ◽

Tubular Adenoma ◽

Malignant Tumours ◽

Colorectal Biopsies ◽

Colon And Rectum ◽

Benign Tumours

Background: Tumours and tumour like lesions of the colon and rectum have overlapping clinical presentation and may be difficult to diagnose on clinical grounds alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be difficult and may require ancillary tests such as immunohistochemistry. Materials and Methods: A prospective cross sectional study enrolled 125 cases of colorectal biopsies after histopathological confirmation of tumours and tumour like lesions. The specimens were received at the Department of Pathology, of TUTH, from December 1, 2015 to November 30, 2016. Results: Out of 125 cases, 32 cases were benign tumours, 36 cases were malignant tumours and 57 cases were tumour like lesions. Most common age range was 51-60 years with mean age of 38 years. Males comprised 76.74% and females 23.26% with ratio of 3:1. Juvenile polyp was the commonest lesion. Among benign tumours, tubular adenoma was the most common (19.2%), adenocarcinoma was most common malignant tumour (25.6%) and juvenile polyp was the most common tumour like lesion (27.2%). Left side was most common side (66.67%) and rectum was the most common site (48.8%). Conclusions: The commonest indications for colorectal biopsies were tumours and tumour like lesions. Juvenile polyp was the most common tumour like lesion, tubular adenoma was the most common benign tumour and adenocarcinoma was the most common malignant tumour. Histopathological examination is a gold standard for confirmation of all tumour and tumours like lesions of colon and rectum.

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Clinical and histopathological correlation of breast lesions

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20181295 ◽

2018 ◽

Vol 6 (4) ◽

pp. 1348

Author(s):

Kavita Sharma ◽

S. P. Vyas ◽

Subhash Dhayal

Keyword(s):

Invasive Carcinoma ◽

Histopathological Examination ◽

Breast Tumors ◽

Mucinous Carcinoma ◽

Malignant Tumour ◽

Benign Tumors ◽

Histopathological Study ◽

Breast Lesions ◽

Malignant Tumours ◽

Neoplastic Lesions

Background: To study the histopathological features of neoplastic and non neoplastic lesions of breast. To correlate the pathological findings with clinical parameters.Methods: We have studied total 170 cases of breast lesions over a period of two years in our institute. The specimens were received in histopathology section of our department. Detailed gross examination of specimens was done followed by fixation, thorough sampling, and tissue processing. The different lesions were studied by histopathological examination and analysed. Neoplastic lesions were classified according to the WHO classification.Results: Out of the 170 cases, 128 cases had neoplastic lesions and 41 cases had non-neoplastic lesions, and one case had coexistent neoplastic and nonneoplastic lesions. Out of the total 129 cases with neoplastic lesions, 76 cases had benign breast tumors, 51 cases had malignant breast tumors, and 2 cases had precursor lesions. Fibroadenoma was the most common benign tumour with 62 cases. Invasive carcinoma no special type was the most common malignant tumour with 43 cases. Special subtypes of invasive carcinoma found in our study were mucinous carcinoma (2 case). The most common nonneoplastic lesion was mastitis with 12 cases, followed by duct ectasia and fibrocystic change. There were 6 cases of gynaecomastia. All the tumors involved upper outer quadrant most frequently. The benign tumors were most frequent in second, third and fourth decades, malignant tumours were seen beyond 4th decade. The nonneoplastic lesions were common in 4th decade.Conclusions: Histopathological study is important in the management of breast lesions.

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Struma Ovarii - A Case Report

KYAMC Journal ◽

10.3329/kyamcj.v7i1.33770 ◽

2017 ◽

Vol 7 (1) ◽

pp. 734-735

Author(s):

Md Mahbur Rashid Sarker ◽

Md Shamim Farooq

Keyword(s):

Histopathological Examination ◽

Ovarian Tissue ◽

Thyroid Tissue ◽

Excision Biopsy ◽

Struma Ovarii ◽

Malignant Tumours ◽

Rare Form ◽

Neoplastic Lesion ◽

Diagnostic Key ◽

Benign Tumours

Struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains mostly thyroid tissue. The vast majority are benign tumours; however, malignant tumours of this type is found in a small percentage of cases. It is most common between the ages of 40 and 60 years and accounts for approximately 5 percent of all ovarian teratomas. Here we present a case of left sided struma ovarii. This patient is a 39 years' woman from Bhobanipur, Rajbari, Bangladesh. She noticed bleeding per vagina, abdominal swelling and left pelvic region mass for few months. Clinical & imaging examination revealed ascites and left ovarian neoplastic lesion. After excision biopsy, histopathological examination was performed. Microscopically, it shows ovarian tissue but predominantly composed of mature thyroid tissue which are diagnostic key feature of struma ovarii.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 734-735

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A rare case of Kimura lymphadenpathy in elderly female

International Surgery Journal ◽

10.18203/2349-2902.isj20204154 ◽

2020 ◽

Vol 7 (10) ◽

pp. 3452

Author(s):

Vinayagam Ganesan ◽

Venkatesh Sadayan Periyasamy ◽

Muralidharan Kannaian

Keyword(s):

Rare Case ◽

Immunoglobulin E ◽

Histopathological Examination ◽

Renal Involvement ◽

Cervical Lymphadenopathy ◽

Surgical Excision ◽

Excision Biopsy ◽

Kimura’S Disease ◽

Recurrence Rates ◽

Elderly Female

Kimura's disease (KD) is a chronic inflammatory disease, a rare variety. It usually presents as non-tender subcutaneous swelling in head and neck region, predominantly in preauricular and submandibular area and is often associated with cervical lymphadenopathy, marked peripheral eosinophilia and an elevated immunoglobulin E (IgE) level. Renal involvement is the only systemic manifestation.4 Nephrotic syndrome is the most common manifestation of renal disease in KD. Diagnosis through Fine needle aspiration cytology (FNAC) is misleading and can easily be mistaken as a malignant disease. So, diagnosis is therefore only established by histopathological examination. The treatment of KD involves one of three major approaches are surgical excision, irradiation, or steroid therapy. Surgical excision is recommended as the treatment of choice but carries recurrence rates of 33-50%. In our study, we are reporting a case of elderly female who presented with left sided cervical lymphadenopathy for which excision biopsy was done and the histopathology examination shown as kimura lymphadenopathy, a rare case.

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Primary Neuroendocrine Carcinoma of Ocular Adnexa

Case Reports in Ophthalmological Medicine ◽

10.1155/2013/281351 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Daisuke Yamanouchi ◽

Toshiyuki Oshitari ◽

Yosuke Nakamura ◽

Jiro Yotsukura ◽

Kaoru Asanagi ◽

...

Keyword(s):

Neuroendocrine Carcinoma ◽

Lacrimal Gland ◽

Histopathological Examination ◽

Combined Therapy ◽

Surgical Excision ◽

Excision Biopsy ◽

Upper Eyelid ◽

Ocular Adnexa ◽

Complete Surgical Excision ◽

The Right

We present our findings in a case of primary neuroendocrine carcinoma (NEC) of the lacrimal gland and a case of primary Merkel cell carcinoma (MCC) of the eyelid. An 86-year-old man noticed a swelling of the left upper eyelid three months earlier. We performed excision biopsy and histopathological examination indicated that he had a primary NEC of the left lacrimal gland. He underwent chemotherapy followed by excision including the clinically visible margins and 50 Gy radiotherapy of the surgical margins. He had neither recurrence nor metastasis for 6 months since the last radiotherapy. An 80-year-old man noticed a nodule in the right upper eyelid and was referred to our hospital because the size was increasing rapidly. A complete surgical excision of the margins of the tumor was performed with histopathological confirmation of negative margins. The final diagnosis was a primary MCC of the right upper eyelid. After surgery, he underwent 50 Gy radiotherapy on the neck to prevent metastasis. No recurrence or metastasis was found for two years. Although primary NEC of the ocular adnexa is extremely rare, the tumor has high malignancy and readily metastasizes. Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC.

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Clinicopathological Study of Lesions of Bone - A Hospital-Based Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2020/448 ◽

2020 ◽

Vol 7 (39) ◽

pp. 2161-2164

Author(s):

Prasanta Kumar Das ◽

Bidyut Dutta ◽

Jabin Musfique ◽

Partha Pratim Das

Keyword(s):

Histopathological Examination ◽

Clinical History ◽

Malignant Tumour ◽

Bone Lesions ◽

Body Parts ◽

Malignant Tumours ◽

Female Ratio ◽

Neoplastic Lesion ◽

Detailed Clinical History ◽

Benign Tumours

BACKGROUND A spectrum of pathological bone lesions can present in any form from inflammatory to neoplastic. These lesions are diverse in their clinical and morphological features and range in behaviour from innocuous to rapidly fatal. Accurate diagnosis, proper staging and appropriate treatment are thus necessary to ensure maximum patient survival and maintain optimal function of the affected body parts. We wanted to determine the pattern of various bone lesions and their relative frequency. METHODS This is a hospital based prospective study. After obtaining detailed clinical history, and examination, biopsies were received in 10 % formalin and histopathological examination was done. RESULTS The maximum number of bone lesions occurred in second decade of life. Out of 91 histopathologically diagnosed bone lesions, 54 (59.3%) were males and 37 (40.7 %) were females, with a male to female ratio of 1.5 : 1. Age ranged from 6 ‑ 70 years. Nonneoplastic lesions accounted for 45.1 %, while neoplastic lesions accounted for 54.9 %. Chronic osteomyelitis was the most common non-neoplastic lesion encountered with 25 cases (27.4 %). Out of 50 cases of bone tumours, benign tumours accounted for 34.1 %, while malignant tumours accounted for 20.9 %. The most common benign tumour in this study was giant cell tumour and the most common malignant tumour was osteosarcoma. The most common presenting complaint of all bone lesions was pain (96.7 %) followed by swelling (75.8 %). CONCLUSIONS For precise diagnosis of majority of bone lesions, histopathology is regarded as the gold standard. A multidisciplinary approach (clinical, radiological and histopathological) is required for exact diagnosis of different lesions. KEYWORDS Histopathology, Osteomyelitis, Bone

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Recurrent Cutaneous Adenoid Cystic Carcinoma of Forehead

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/51034.15510 ◽

2021 ◽

Author(s):

Ashi Vijayaraghavan ◽

Subhashini Ramamoorthy ◽

Sylvia Mary Theresa ◽

Banushree C Srinivasamurthy ◽

Sankappa P Sinhasan

Keyword(s):

Adenoid Cystic Carcinoma ◽

Histopathological Examination ◽

Malignant Tumour ◽

Tumour Cells ◽

Malignant Tumours ◽

Sebaceous Cyst ◽

Margins Of Excision ◽

Adenoid Cystic ◽

Biopsy Report ◽

Adnexal Tumour

Adenoid Cystic Carcinoma (ACC) is a malignant tumour more commonly seen in salivary glands and rarely arises from the skin as adnexal tumour. Cutaneous ACC is a rare malignant adnexal tumour of eccrine origin. It has an indolent course and rarely metastasizes. Hereby, authors report a case of 48-year-old male with complaints of swelling on right forehead present for the past four years. Clinical diagnosis of infected sebaceous cyst was made and excised with simple excision. The swelling reappeared within 15 days of first surgery. The cytological examination of the swelling revealed abundant cellularity with predominantly cohesive clusters of monomorphic population of cells centered around eosinophilic hyaline globules suggestive of ACC. Retrieval of previous biopsy report revealed diagnosis of ACC reaching the margins of excision, the report of which was neither collected by either operating surgeon nor by the patient. Histopathological examination revealed classical cribriform pattern of arrangement of tumour cells with perineural infiltration by tumour cells. Immunohistochemistry further confirmed the diagnosis. The present case report brings out the importance of clearance of surgical margins in malignant tumours, including skin adnexal tumours. It also highlights the importance of histopathological examination of benign looking skin adnexal tumours.

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The investigation of histopathology and locations of excised eyelid masses in dogs

Veterinary Record Open ◽

10.1136/vetreco-2019-000344 ◽

2019 ◽

Vol 6 (1) ◽

pp. e000344

Author(s):

Shang-Lin Wang ◽

Charlotte Dawson ◽

Li-Ning Wei ◽

Chung-Tien Lin

Keyword(s):

Surgical Excision ◽

Lower Eyelid ◽

Good Prognosis ◽

Malignant Tumours ◽

Upper Eyelid ◽

Ocular Irritation ◽

Common Location ◽

Benign Tumours ◽

Pathology Reports ◽

Mass Volume

BackgroundEyelid masses are the most common ocular diseases in dogs. However, there are no studies specifically investigating the location of eyelid masses.Methods118 dogs with 119 eyelid masses were included. Medical records and pathology reports were retrospectively reviewed at National Taiwan University veterinary hospital and Vision Eyecare Centre for Animals between 2012 and 2017.ResultsMean age of dogs was 9.4±2.5 years. Female spayed dogs had significantly higher prevalence of eyelid mass than female intact dogs (p<0.01). Prevalence of upper eyelid mass was significantly higher than lower eyelid mass (p<0.01). The upper lateral eyelid was the significantly more common location compared with the upper medial eyelid. Mean mass volume was 258.2±661.0 mm3. The most common eyelid mass type was meibomian epithelioma (34.5%), followed by meibomian adenoma (29.4%) and meibomian hyperplasia (18.5%). Non-tumours comprised 25.2%, benign tumours comprised 67.2% and malignant tumours comprised 7.6% of all eyelid masses. Malignant tumours were significantly larger than benign lesions (p<0.01). All dogs underwent surgical excision without any complications.ConclusionThe majority of eyelid masses were benign. Surgical intervention can prevent further ocular irritation and provide good prognosis.

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