scholarly journals A histopathological review of nephrectomy specimens with an emphasis on pathological assessment of prognostic indicators in malignant lesions

Biomedicine ◽  
2021 ◽  
Vol 40 (4) ◽  
pp. 492-501
Author(s):  
Shubha P. Bhat ◽  
Krishna Prasad H.V. ◽  
Rajeev T.P. ◽  
Kishan Prasad H.L. ◽  
Teerthanath Srinivas ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Malignant Tumour ◽  
Prognostic Indicators ◽  
Wilms Tumour ◽  
Malignant Tumours ◽  
Neoplastic Lesions ◽  
Kidney Lesion ◽  
Microscopic Features ◽  
Malignant Lesions ◽  
Pathological Assessment

Introduction and Aim: Various non-neoplastic and neoplastic lesions occur in the kidney. Pathological assessment of gross and microscopic features in nephrectomy specimens is essential for diagnosis and predicts the prognosis in malignant tumours. Materials and Methods: Case records of 46 nephrectomy specimens received between two-year periods were retrieved. Detailed gross and histopathological and immunohistochemical features were studied, and malignant tumours were analysed using CAP protocol. Results: Out of 46 nephrectomy specimens, 17 were non-neoplastic and 29 neoplastic. Males constituted 32 cases and females 14 cases. The commonest non-neoplastic kidney lesion was chronic pyelonephritis with hydronephrosis (29%). The mixed epithelial and stromal tumour was the frequently encountered benign tumour (50%). Renal cell carcinoma was the most common malignant tumour in adults (70%) and Wilms tumour in children (4%). Conclusion: Histopathological examination of nephrectomy specimens helps in diagnosing, staging, and planning the management.

scholarly journals A CLINICO -PATHOLOGICAL STUDY OF NEOPLASTIC AND NON-NEOPLASTIC OVARIAN LESIONS.

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Dr. Reena Verma ◽  
Dr. Kulwant Singh ◽  
Dr. Swaran Kaur ◽  
Dr. Rajiv Mahendru ◽  
Dr. Deepti Agarwal ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Abnormal Uterine Bleeding ◽  
Final Diagnosis ◽  
Reproductive Organs ◽  
Malignant Tumours ◽  
Patient Age ◽  
Patient Âgé ◽  
Neoplastic Lesions ◽  
Malignant Lesions ◽  
Gross Examination

Background: Ovarian lesions constitute a complex group with varied clinical behaviour and pathology. The ovaries constitute the internal reproductive organs their lesions can present in childhood to postmenopausal age group Clinical, radiological and gross examination alone cannot distinguish benign from malignant lesions; hence, histopathological examination is needed for their diagnosis and management. Objectives: A Clinico -pathological analysis of non-neoplastic and neoplastic ovarian lesions. Materials and methods:  This descriptive study of one year comprised of 80 ovarian lesions diagnosed in the Department of Pathology, Bhagat Phool Singh Government medical college Sonipat. After thorough gross examination, representative bits were routinely processed and stained with H & E. Tumours were classified as per WHO classification. Results: Out of 80 ovarian lesions received, non-neoplastic lesions constituted 39% (31/80). Benign lesions constituted 45% (36/80) whereas borderline and malignant lesions constituted 5% (4/80) and 11.25% (9/80) respectively.  Among non-neoplastic lesions, follicular cysts (67.7%) constituted the majority followed by corpus luteal cysts and endometriotic cysts. Among neoplastic lesions majority of the tumours were of surface epithelial type (69.38%) followed by germ cell tumours (18.36%).  Bilateral lesions were seen in 17 (26.98%) patients while unilateral lesions were seen in 46 (73.01%) patients.  Patients age varied from 16 to 75 years. For non-neoplastic lesions, patient age varied from 16 to 61 years. For neoplastic lesions patient age ranged from 18-75 years with age range of 18-75 years for benign tumours and 26-66 years for malignant tumours. Abnormal uterine bleeding was the commonest clinical presentation of non-neoplastic lesions. Benign and malignant tumours were most commonly associated with pain abdomen. Conclusion: Ovarian lesions comprise of variety of non-neoplastic and neoplastic lesions. By knowing clinical data, gross features, we can narrow our differential diagnosis and reach to the final diagnosis.  So, early diagnosis and treatment definitely reduce the mortality from ovarian tumours. Keywords: Non-neoplastic, Benign, Malignant, Ovary, Lesions, Cysts, Tumours.

scholarly journals Clinical and histopathological correlation of breast lesions

2018 ◽  
Vol 6 (4) ◽  
pp. 1348
Author(s):  
Kavita Sharma ◽  
S. P. Vyas ◽  
Subhash Dhayal
Keyword(s):  
Invasive Carcinoma ◽  
Histopathological Examination ◽  
Breast Tumors ◽  
Mucinous Carcinoma ◽  
Malignant Tumour ◽  
Benign Tumors ◽  
Histopathological Study ◽  
Breast Lesions ◽  
Malignant Tumours ◽  
Neoplastic Lesions

Background: To study the histopathological features of neoplastic and non neoplastic lesions of breast.  To correlate the pathological findings with clinical parameters.Methods: We have studied total 170 cases of breast lesions over a period of two years in our institute. The specimens were received in histopathology section of our department. Detailed gross examination of specimens was done followed by fixation, thorough sampling, and tissue processing. The different lesions were studied by histopathological examination and analysed. Neoplastic lesions were classified according to the WHO classification.Results: Out of the 170 cases, 128 cases had neoplastic lesions and 41 cases had non-neoplastic lesions, and one case had coexistent neoplastic and nonneoplastic lesions. Out of the total 129 cases with neoplastic lesions, 76 cases had benign breast tumors, 51 cases had malignant breast tumors, and 2 cases had precursor lesions. Fibroadenoma was the most common benign tumour with 62 cases. Invasive carcinoma no special type was the most common malignant tumour with 43 cases. Special subtypes of invasive carcinoma found in our study were mucinous carcinoma (2 case). The most common nonneoplastic lesion was mastitis with 12 cases, followed by duct ectasia and fibrocystic change. There were 6 cases of gynaecomastia. All the tumors involved upper outer quadrant most frequently. The benign tumors were most frequent in second, third and fourth decades, malignant tumours were seen beyond 4th decade. The nonneoplastic lesions were common in 4th decade.Conclusions: Histopathological study is important in the management of breast lesions.

HISTOPATHOLOGICALANALYSIS OF TUMOURS AND TUMOUR-LIKE LESIONS OF COLON AND RECTUM

2021 ◽  
pp. 9-11
Author(s):  
Durga Nand Jha ◽  
Hari Shankar Mishra ◽  
Ajit Kumar Chaudhary ◽  
Debarshi Jana
Keyword(s):  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Malignant Tumour ◽  
Juvenile Polyp ◽  
Tubular Adenoma ◽  
Malignant Tumours ◽  
Cross Sectional ◽  
Colorectal Biopsies ◽  
Colon And Rectum ◽  
Benign Tumours

Background:Tumours and tumour like lesions of the colon and rectum have overlapping clinical presentation and may be difcult to diagnose on clinical grounds alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be difcult and may require ancillary tests such as immunohistochemistry. Materials and Methods: A prospective cross sectional study enrolled 125 cases of colorectal biopsies after histopathological conrmation of tumours and tumour like lesions. The specimens were received at the Department of Pathology, DMCH, Laheriasarai, Bihar from December 2019 to November 2020. Results: Out of 125 cases, 32 cases were benign tumours, 36 cases were malignant tumours and 57 cases were tumour like lesions. Most common age range was 51-60 years with mean age of 38 years. Males comprised 76.74% and females 23.26% with ratio of 3:1. Juvenile polyp was the commonest lesion. Among benign tumours, tubular adenoma was the most common (19.2%), adenocarcinoma was most common malignant tumour (25.6%) and juvenile polyp was the most common tumour like lesion (27.2%). Left side was most common side (66.67%) and rectum was the most common site (48.8%). Conclusions: The commonest indications for colorectal biopsies were tumours and tumour like lesions. Juvenile polyp was the most common tumour like lesion, tubular adenoma was the most common benign tumour and adenocarcinoma was the most common malignant tumour. Histopathological examination is a gold standard for conrmation of all tumour and tumours like lesions of colon and rectum.

scholarly journals Histopathological Scenario of Testicular Lesions with Few Uncommon Entities – 3 Years Study in a Tertiary Care Hospital

2021 ◽  
Vol 8 (9) ◽  
pp. 467-470
Author(s):  
Padma Madana ◽  
Vijayasree Mandava ◽  
Neelima Govada ◽  
Padmavathi Devi Chaganti ◽  
Zafrul Haque Mohammed ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Common Finding ◽  
Care Hospital ◽  
Malignant Tumours ◽  
Cell Hyperplasia ◽  
Equal Distribution ◽  
Splenogonadal Fusion ◽  
Inflammatory Conditions ◽  
Neoplastic Lesions

BACKGROUND The incidence of testicular malignancy has been increasing in men, orchidectomy is necessary for the removal of neoplastic lesions or in patients with chronic inflammatory conditions resistant to treatment. We wanted to evaluate the various histopathological patterns of lesions in testis. METHODS A retrospective study of 86 orchidectomy specimens over a period of three years with age wise distribution from March 2017 to February 2020 was done in the Department of Pathology, Guntur Medical College, Guntur. Histopathological slides stained with haematoxylin and eosin were retrieved and reviewed. Immunohistochemistry was done in two cases. RESULTS Of the 86 cases, 78 (90.7 %) cases were non neoplastic and 8 (9.3 %) cases were neoplastic. Youngest age in non-neoplastic group was four days and in neoplastic group was 18 years. The oldest age was 82 years in the non-neoplastic lesions and 60 years in the neoplastic lesions. Non neoplastic lesions were common in the 3 rd decade. In malignant lesions, highest number of cases was seen in the 6 th decade and equal distribution was observed in 3rd and 5th decade. Unilateral involvement was common than bilateral involvement. Out of all non-neoplastic lesions, undescended testis 20 (25.64 %) cases was the common finding followed by non-specific epididymo orchitis 19 (24.36 %) cases, abscess 14 (17.95 %) cases, torsion infarction 13 (16.67 %) cases, Leydig cell hyperplasia 4 (5.13 %) cases, 3 (3.85 %) cases each of tuberculous epididymo orchitis and granulomatous epididymo orchitis. 1 (1.28 %) case each of rare entities like vanishing testis and splenogonadal fusion were also found. Among the neoplastic lesions, all 8 cases were malignant tumours. Out of these malignant tumours, mixed germ cell tumours were seen in 3 (37.5 %) cases followed by seminomas 2 (25 %) cases, post pubertal teratoma 1 (12.5 %) case, non-Hodgkin’s lymphoma (NHL) 1 (12.5 %) case and primitive neuroectodermal tumour (PNET) 1 (12.5 %) case. CONCLUSIONS Histopathological examination on routine haematoxylin and eosin (H&E) stained sections primarily differentiate non neoplastic lesions from neoplastic group and benign tumours from malignant tumours as the treatment modality varies. Immunohistochemistry (IHC) is useful in the diagnosis of poorly differentiated small round cell tumours. KEYWORDS Orchidectomy Specimens, Neoplastic and Non-Neoplastic Lesions

scholarly journals Histopathological analysis of tumours and tumour-like lesions of colon and rectum

2020 ◽  
Vol 10 (1) ◽  
pp. 1654-1658
Author(s):  
Pramila Vaidhya ◽  
Ram Chandra Adhikari ◽  
Anil Dev Pant
Keyword(s):  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Malignant Tumour ◽  
Juvenile Polyp ◽  
Histopathological Analysis ◽  
Tubular Adenoma ◽  
Malignant Tumours ◽  
Colorectal Biopsies ◽  
Colon And Rectum ◽  
Benign Tumours

Background: Tumours and tumour like lesions of the colon and rectum have overlapping clinical presentation and may be difficult to diagnose on clinical grounds alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be difficult and may require ancillary tests such as immunohistochemistry. Materials and Methods: A prospective cross sectional study enrolled 125 cases of colorectal biopsies after histopathological confirmation of tumours and tumour like lesions. The specimens were received at the Department of Pathology, of TUTH, from December 1, 2015 to November 30, 2016. Results: Out of 125 cases, 32 cases were benign tumours, 36 cases were malignant tumours and 57 cases were tumour like lesions. Most common age range was 51-60 years with mean age of 38 years. Males comprised 76.74% and females 23.26% with ratio of 3:1. Juvenile polyp was the commonest lesion. Among benign tumours, tubular adenoma was the most common (19.2%), adenocarcinoma was most common malignant tumour (25.6%) and juvenile polyp was the most common tumour like lesion (27.2%). Left side was most common side (66.67%) and rectum was the most common site (48.8%). Conclusions: The commonest indications for colorectal biopsies were tumours and tumour like lesions. Juvenile polyp was the most common tumour like lesion, tubular adenoma was the most common benign tumour and adenocarcinoma was the most common malignant tumour. Histopathological examination is a gold standard for confirmation of all tumour and tumours like lesions of colon and rectum.

scholarly journals Report of an unusually Huge Fibroepithelial Polyp managed with Diode Laser

2015 ◽  
Vol 6 (2) ◽  
pp. 52-55
Author(s):  
Rithesh Kulal ◽  
Shashwati Paul ◽  
Anuroopa Pudukulangara ◽  
Savita Sambashivaiah
Keyword(s):  
Diode Laser ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Benign Tumors ◽  
Fibroepithelial Polyp ◽  
Neoplastic Lesions ◽  
Histological Variant ◽  
Malignant Lesions ◽  
Laser Excision ◽  
Functional Problems

ABSTRACT Fibromas are benign tumors that are composed of fibrous connective tissue. Fibroepithelial polyp (FEP) is a histological variant of fibroma that causes esthetic and functional problems. They may arise anywhere in the oral cavity, but are more commonly seen in the gingiva, tongue, and lip. Generally small and painless, they rarely continue to grow and might resemble other malignant lesions. This article reports an unusual case of a huge intraoral FEP that presented as a cauliflower-shaped lesion mimicking other neoplastic lesions. Laser excision was carried out following which histopathological examination revealed it as an inflamed FEP with ulceration. How to cite this article Paul S, Pudukulangara A, Kulal R, Sambashivaiah S. Report of an unusually Huge Fibroepithelial Polypmanagedwith Diode Laser. JHealth Sci Res 2015;6(2):52-55.

scholarly journals A report of 26 cases of ovarian lesions as seen in a Tertiary Institution in North-East Nigeria

2014 ◽  
Vol 2 (4) ◽  
Author(s):  
Abdullahi K ◽  
Mohammed U ◽  
Aminu BM ◽  
Dattiji LM
Keyword(s):  
Corpus Luteum ◽  
Age Distribution ◽  
Malignant Tumour ◽  
Serous Cystadenoma ◽  
Malignant Tumours ◽  
Tertiary Institution ◽  
North East ◽  
Neoplastic Lesions ◽  
Age Range ◽  
Corpus Luteum Cyst

varian cancer is a lethal disease. Globally, it claims 125,000 lives per year. Non-neoplastic lesions of the ovary frequently mimic ovarian neoplasms; many occur in the reproductive years and may be associated with infertility. The clinical diagnosis of ovarian cancers is still problematic when compared with that of the cervix owing to the fact that the ovary is less accessible and there has been no universally accepted screening protocol. : To study the pattern and age distribution of non-neoplastic and neoplastic lesions of the ovary in a tertiary institution in North – east Nigeria and compare it with other centers. : It was a retrospective retrieval of oopherectomy specimens seen over a 1 year period with review of their histopathologic characteristics. : A total of 26 oophorectomy specimens were received within the study st st period (1 January 2012 to 31 December 2012). There were 11(42.3%) nonneoplastic conditions and 15(57.7%) neoplastic conditions of which 8 (30.8%) were benign and 7 (26.9%) malignant tumours .The age range of non-neoplastic conditions was 20 to 49 years. Corpus luteum cyst was the most common lesion 4 (15.4%) and a case of ovarian ectopic gestation was observed. Neoplastic lesions were predominantly observed in fourth, third and second decades of life with age range of 17 years to 72 years. Papillary serous Cystadenocarcinoma was the most common malignant tumour, 5(19.2%). : The most common non-neoplastic ovarian lesion was Corpus luteum cyst and the most common benign and malignant ovarian neoplasm was papillary serous Cystadenoma and papillary serous Cystadenocarcima respectively. A further review may be needed in the future to compare epidemiologic trends in the environment

scholarly journals Diagnosis of upper gastrointestinal lesions by endoscopy and its correlation with histopathology

2020 ◽  
Vol 8 (2) ◽  
pp. 100-105
Author(s):  
Santhi Kiran D. ◽  
Nagarjuna Kumar Y. R.
Keyword(s):  
Gastrointestinal Tract ◽  
Diagnostic Procedure ◽  
Histopathological Examination ◽  
Wide Spectrum ◽  
Age Groups ◽  
Gastric Cavity ◽  
Gastrointestinal Lesions ◽  
Neoplastic Lesions ◽  
Malignant Lesions ◽  
Upper Gastrointestinal

Background: A wide spectrum of lesions can be encountered in the upper gastrointestinal tract (GIT) especially the stomach or the gastric cavity. Endoscopy forms a crucial diagnostic procedure; it gives good diagnostic results in non-neoplastic lesions, endoscopy with biopsy is usually done in neoplastic lesions where the differentiation of benign and malignant lesions cannot be made always. Materials and Methods: This is a retrospective cum prospective study and the duration of this study was 4 yearsfrom January 2015 to December 2019 and the total number of endoscopic procedures performed was 3978. All patients with symptoms pertaining to the upper GIT where Upper Gastro-Intestinal Endoscopy (UGI Endoscopy) is useful in diagnosis were included in this study. All age groups and both the sexes were included. Biopsy was taken wherever there was an indication. Results: In this study, a total of 3978 endoscopies were done, out of which 2689 patients were males (67.6%) and 1289 were females (32.4%), youngest patient age in this study was 13 years and the oldest was 79 years. Most of the lesions were located in the gastric cavity (48% - 1909 cases), followed by esophagus (34%-1353 cases) and least among the three in the duodenum (18%- 716 cases). Out of the 3978 lesions, 134 cases were diagnosed as carcinoma on endoscopy and they were confirmed by histopathological examination. Conclusion: Endoscopy plays a very important role in the diagnosis of upper GIT lesions and it is incomplete without histopathological examination of biopsied tissue in cases of neoplastic lesions

scholarly journals A Peculiar Case of Cutaneous Eyelid Melanoma: Clinicopathological Questions and Therapeutic Challenges

2020 ◽  
Vol 25 (2) ◽  
pp. 15-17
Author(s):  
Alin Dumitru Ciubotaru ◽  
Constantin Grigoraș ◽  
Carmen-Ecaterina Leferman
Keyword(s):  
Histopathological Examination ◽  
Cutaneous Lesion ◽  
Primary Melanoma ◽  
Surgical Excision ◽  
Malignant Tumour ◽  
Lower Eyelid ◽  
Excision Biopsy ◽  
Malignant Tumours ◽  
Eyelid Margin ◽  
Ocular Ultrasound

AbstractPrimary melanoma of the eyelid is a rare malignant tumour that accounts for <1% of all malignant melanomas and about 1% of malignant tumours of the eyelid. The most common clinical presentation of melanoma is an oval lesion; linear presentation is uncommon. We presented a 79-year-old woman with a several-month history of a rapidly-growing, irregular, linear, pigmented cutaneous lesion on the right lower eyelid, involving the eyelid margin. The lesion measured 2 cm x 0,8 cm x 0,2 cm. Anterior and posterior segments appeared normal in both eyes, without pathological findings on ocular ultrasound examination. After excision biopsy, histopathological examination revealed a nodular melanoma. The case underwent additional investigations for staging and therapy. The current therapeutic strategies in eyelid melanoma include surgical excision, systemic chemotherapy, immunotherapy, targeted therapy or radiotherapy. Despite advanced research methods in the field, the management of eyelid melanoma is still a major challenge.

scholarly journals Clinicopathological Study of Lesions of Bone - A Hospital-Based Study

2020 ◽  
Vol 7 (39) ◽  
pp. 2161-2164
Author(s):  
Prasanta Kumar Das ◽  
Bidyut Dutta ◽  
Jabin Musfique ◽  
Partha Pratim Das
Keyword(s):  
Histopathological Examination ◽  
Clinical History ◽  
Malignant Tumour ◽  
Bone Lesions ◽  
Body Parts ◽  
Malignant Tumours ◽  
Female Ratio ◽  
Neoplastic Lesion ◽  
Detailed Clinical History ◽  
Benign Tumours

BACKGROUND A spectrum of pathological bone lesions can present in any form from inflammatory to neoplastic. These lesions are diverse in their clinical and morphological features and range in behaviour from innocuous to rapidly fatal. Accurate diagnosis, proper staging and appropriate treatment are thus necessary to ensure maximum patient survival and maintain optimal function of the affected body parts. We wanted to determine the pattern of various bone lesions and their relative frequency. METHODS This is a hospital based prospective study. After obtaining detailed clinical history, and examination, biopsies were received in 10 % formalin and histopathological examination was done. RESULTS The maximum number of bone lesions occurred in second decade of life. Out of 91 histopathologically diagnosed bone lesions, 54 (59.3%) were males and 37 (40.7 %) were females, with a male to female ratio of 1.5 : 1. Age ranged from 6 ‑ 70 years. Nonneoplastic lesions accounted for 45.1 %, while neoplastic lesions accounted for 54.9 %. Chronic osteomyelitis was the most common non-neoplastic lesion encountered with 25 cases (27.4 %). Out of 50 cases of bone tumours, benign tumours accounted for 34.1 %, while malignant tumours accounted for 20.9 %. The most common benign tumour in this study was giant cell tumour and the most common malignant tumour was osteosarcoma. The most common presenting complaint of all bone lesions was pain (96.7 %) followed by swelling (75.8 %). CONCLUSIONS For precise diagnosis of majority of bone lesions, histopathology is regarded as the gold standard. A multidisciplinary approach (clinical, radiological and histopathological) is required for exact diagnosis of different lesions. KEYWORDS Histopathology, Osteomyelitis, Bone

Sign in / Sign up

Export Citation Format

Share Document