Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis
Keyword(s):
AbstractProcaspase-9 is the zymogen form of one of the apoptosis initiators, caspase-9. Its cellular location may differ depending on the cell type; it is found throughout the cytosol, although some of it may be associated with the mitochondria. Procaspase-9 relocates from the cytosol to the mitochondria shortly after the triggering of apoptosis in rat hepatocytes. We investigated whether the mitochondrial protein import machineries import procaspase-9. The combined results of protein import analyses, mitochondrial fractionation and protease treatments of intact and swollen mitochondria imply that procaspase-9 attaches to the outer surface of the mitochondrial outer membrane.
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2010 ◽
Vol 21
(18)
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pp. 3106-3113
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1998 ◽
Vol 274
(5)
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pp. C1380-C1387
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