Synthesis, characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide

2009 ◽  
Vol 63 (4) ◽  
Author(s):  
Jian-Qiang Qu ◽  
Ling Qu ◽  
Qiu-Hua Yang ◽  
Liu-Fang Wang
Keyword(s):  
Thermal Analysis ◽  
Transition Metal ◽  
Tumor Cells ◽  
General Formula ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Acid Hydrazide ◽  
Complexometric Titration ◽  
Anti Tumor Activity

AbstractFour transition metal(II) complexes with podophyllic acid hydrazide (HL) were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR, and 1H NMR. The complexes have the general formula ML2 · nH2O, where M = Zn, Cu, Co, and Ni, n = 2 or 0. Anti-tumor activities of podophyllotoxin, HL, ZnL2 · 2H2O, and NiL2 were tested by both the MTT and the SRB method. The results show that the activities of the complexes against the tumor cells tested are superior to HL and the anti-tumor activity of NiL2 is even similar to that of podophyllotoxin.

Synthesis, characterization, and biological activities of some transition metal(II) complexes with the thiosemicarbazone derived from 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one

2006 ◽  
Vol 60 (3) ◽  
Author(s):  
J. Qu ◽  
G. Sun ◽  
L. Wang ◽  
L. Qu
Keyword(s):  
Biological Activity ◽  
Transition Metal ◽  
General Formula ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Nmr Spectra ◽  
Biological Activities ◽  
Antitumour Activity ◽  
Molar Conductivity

AbstractA new 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one thiosemicarbazone (HL) was synthesized derived from 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one. Four transition metal(II) complexes of HL have been prepared. Elemental analysis, molar conductivity, IR, UV, 1H NMR spectra, and TG-DTA have been used to characterize these complexes. The complexes have the general formula ML2, where M = Zn, Cu, Co, and Ni. The ligand and its complexes have been studied for their possible biological activity including anti-inflammatory, antibacterial, and antitumour activity in vitro.

scholarly journals Transition metal complexes with thiosemicarbazide-based ligands. Part 60. Reactions of copper(II) bromide with pyridoxal S-methylisothiosemicarbazone (PLITSC). Crystal structure of [Cu(PLITSC−H)H2O]Br•H2O

2014 ◽  
Vol 79 (3) ◽  
pp. 291-302 ◽  
Author(s):  
Vukadin Leovac ◽  
Ljiljana Vojinovic-Jesic ◽  
Sonja Ivkovic ◽  
Marko Rodic ◽  
Ljiljana Jovanovic ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Thermal Analysis ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Structural Characterization ◽  
Electronic Spectra ◽  
Square Planar

The synthesis and structural characterization of a square-planar copper(II) complex with pyridoxal S-methylisothiosemicarbazone (PLITSC) of the formula [Cu(PLITSC?H)H2O]Br?H2O (1) as the first Cu(II) complex with monoanionic form of this ligand were described. Complex 1 together with two previously synthesized complexes [Cu(PLITSC)Br2] (2) and [Cu(PLITSC)Br(MeOH)]Br (3) were characterized by elemental analysis, IR and electronic spectra and also by the methods of thermal analysis, conductometry and magnetochemistry.

scholarly journals Metal ion promoted synthesis of pentaazamacrocyclic complexes of a few first row transition metal series derived from 2,6-diaminopyridine

2005 ◽  
Vol 70 (11) ◽  
pp. 1273-1281
Author(s):  
Ali Khan ◽  
Shabana Tabassum ◽  
Nishat Begum ◽  
Poonam Chingsubam
Keyword(s):  
Magnetic Susceptibility ◽  
Transition Metal ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Metal Ion ◽  
Condensation Reaction ◽  
Spectroscopic Techniques ◽  
Conductivity Measurements ◽  
Template Condensation ◽  
Square Planar

Anew series of dichloro/dinitrato (2,6,9,13,18-pentaazacbicyclo [12.3.1]octadeca -1(18),14,16-triene) metal(II) [MLX2](M = Mn(II), Co(II), Ni(II) and Zn(II); X = Cl or NO3) and (2,6,9,13,18-pentaazacyclo[12.3.1]octadeca-1(18),14,16-triene) copper(II) dichloride/dinitrate [CuL]X2 (X = Cl or NO3) have been synthesized by the template condensation reaction of 2,6-diaminopyridine with 1,2-diaminoethane and 1,3-dibromopropane. The complexes were studied by elemental analysis, magnetic susceptibility and conductivity measurements. Various spectroscopic techniques, viz. IR, 1H-NMR, EPR, UV/Vis, were used to establish their structures. Except for the complexes of copper(II), which are square planar, all other complexes have octahedral structures.

scholarly journals Synthesis, characterisation and reactions of cationic complexes of Arylantimony (III) chlorides ArnSbCl3-n with perchlorate and tetrafluoroborate anions

2013 ◽  
Vol 1 (2) ◽  
pp. 42-48
Author(s):  
Ram Nath Prasad Yadav
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
General Formula ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Chemical Data ◽  
Physico Chemical ◽  
Hexamethyl Phosphoramide

Several hitherto unreported cationic complexes of the general formula [Ar2SbL][Y] and [ArSbL2][Y]2 [ Where, Ar  =  C6H5, L =  α-Picoline, Pyridine, Ph3AsO, hexamethyl phosphoramide (HMPA), thiourea (TU) and Y = ClO4− BF4− ] have been synthesized and characterized by solid state IR, 1H NMR, elemental analysis, conductance and molecular weight measurements. The physico-chemical data, cations [Ar2SbL]+1 and[ArSbL2]+2  are assigned a pyramidal structure.DOI: http://dx.doi.org/10.3126/ijasbt.v1i2.8204 Int J Appl Sci Biotechnol, Vol. 1(2): 42-49

scholarly journals Synthesis and Characterizationof Some New Phenolic Schiff Bases Derivatives

2013 ◽  
Vol 10 (2) ◽  
pp. 377-387
Author(s):  
Baghdad Science Journal
Keyword(s):  
Thermal Analysis ◽  
Schiff Bases ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr

Starting from bis (4,4'-diamino phenoxy) ethan(1), a variety of phenolicschiff bases (methylolic, etheric, epoxy) derivatives have been synthesized. All proposed structure were supported by FTIR, 1H-NMR, 13C-NMR Elemental analysis, some derivatives evaluated by thermal analysis (TGA).

scholarly journals Preparation and Characterisation of complex Bis(pentafluorophenyl) antimony(V) anions of the type [(Rf)2SbCl3X]-

2013 ◽  
Vol 1 (3) ◽  
pp. 90-96 ◽  
Author(s):  
Ram Nath Prasad Yadav
Keyword(s):  
Solid State ◽  
Spectral Data ◽  
General Formula ◽  
1H Nmr ◽  
Elemental Analysis ◽  
19F Nmr ◽  
Chemical Data ◽  
Molecular Weights ◽  
Counter Ions ◽  
Physico Chemical

A series of hiteherto unreported solid salts of hexa-coordinated anions of the general formula [(Rf)2SbCl3X]- , where Rf = C6F5 ; L = Cl and X = Cl, Br, I, N3, NCS and SeCN have been prepared in the presence of tetraorgano ammonium, phosphonium, arsonium and stibonium counter ions. The complexes have been formulated and characterised on the basis of elemental analysis, molar conductances, molecular weights and solid state IR, solution state 1H NMR and 19F NMR spectral data. The physico-chemical data are consistent with six-coordinate antimony complexes.DOI: http://dx.doi.org/10.3126/ijasbt.v1i3.8304 Int J Appl Sci Biotechnol, Vol. 1(3) 2013 : 90-96

scholarly journals Correlation between the structure and biological activity of some coordination compounds of isatin Schiff bases

2003 ◽  
Vol 57 (10) ◽  
pp. 444-448 ◽  
Author(s):  
Blaga Radovanovic ◽  
Sandra Konstantinovic
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Transition Metal ◽  
Schiff Bases ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Coordination Compounds ◽  
Molar Conductivity ◽  
Enhanced Activity

The complexes of Co(ll), Ni(ll), Cu(ll) and Zn(ll) with isatin Schiff bases were synthetised and their structures established by using elemental analysis, as well as by measuring the molar conductivity, AA, FTIR, UV/VIS and 1H NMR and applying TG analysis.Isatin Schiff bases show different antimicrobial activity due to the different nature of the carbonyl and amino components as well as its substituent. The complexes have an enhanced activity compared to the ligands due to the transition metal involved in the coordination. It is also evident that the complexes have different antimicrobial activity, which is related to the nature and typeof coordinated metal.

scholarly journals Synthesis and Characterization of New phenolic Schiff bases Derivatives Based on Terephthaladehyde

2013 ◽  
Vol 10 (3) ◽  
pp. 699-711
Author(s):  
Baghdad Science Journal
Keyword(s):  
Thermal Analysis ◽  
Schiff Bases ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Synthesis And Characterization

A variety of new phenolic Schiff bases derivatives have been synthesized starting from Terephthaladehyde compound, all proposed structures were supported by FTIR, 1H-NMR, 13C-NMR, Elemental analysis, some derivatives evaluated by Thermal analysis (TGA).

scholarly journals Dinuclear UO2(VI), Th(IV), ZrO(IV) and VO(IV) complexes based on some Schiff-base ligands: Synthesis and structural elucidation

2013 ◽  
Vol 2 (1) ◽  
pp. 50-56
Author(s):  
Ranjan K. Mohapatra ◽  
S. Ghosh ◽  
P. Naik ◽  
D. C. Dash
Keyword(s):  
Thermal Analysis ◽  
Schiff Base ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Molar Conductivity ◽  
Template Method ◽  
Nmr Studies ◽  
Schiff Base Ligands ◽  
Paramagnetic Complexes

A series of homo binuclear complexs of the type [M2(L/L’)(NO3)n(H2O)2], [where M=UO22+, Th4+, ZrO2+] and [(VO)2(L/L’)(SO4)(H2O)], L= 4, 17-di(o-hydroxyphenyl)-5,6,9,12,15,16-hexaaza-7,8,13,14-tetraphenyl heptadec-4, 6, 8, 12, 14, 16-hexene or L’= 10:11-benzo-4, 17-di(o-hydroxyphenyl)-5,6,9,12,15,16-hexaaza-7,8,13,14-tetraphenyl heptadec-4, 6, 8, 12, 14, 16-hexene, n=2 for UO22+, ZrO2+  n=6 for Th4+, have been synthesized in template method from ethylenediamine/orthophenylene diamine, benzil monohydrazone and salicyldehyde and characterized on the basis of elemental analysis, thermal analysis, molar conductivity, magnetic moment, electronic, infrared, 1H-NMR studies.  The results indicate that the VO(IV) ion is penta co-ordinated yielding paramagnetic complexes; UO2(VI), ZrO(IV) ions are hexa co-ordinated where as Th(IV) ion is octa co-ordinated yielding diamagnetic complexes of above composition.

scholarly journals TRANSITION METAL COMPLEXES OF HETEROCYCLIC LIGANDS. PART VI. COMPLEXES OF 5-HYDROXY-6-MERCAPTO-BENZO[a]PHENAZINE WITH Co(II), Ni(II), Cu(II), Zn(II) AND Cd(II)

2002 ◽  
Vol 10 (11) ◽  
pp. 33-38
Author(s):  
A. Reiss ◽  
G. Bratulescu ◽  
A. Kriza ◽  
N. Muresan
Keyword(s):  
Thermal Analysis ◽  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Spectral Analysis ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Heterocyclic Ligands ◽  
Heterocyclic Ligand

The paper reports the conclusions about the structure of jive new romp/exes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with the heterocyclic ligand, 5-hydroxy-6-mercapto- benzo[a] phenazine (H2L). These were obtained by elemental analysis, IR, UV-VIS and EPR spectral analysis, conductivity and magnetic susceptibility measurements, and thermal analysis. Bacteriological studies revealed that the ligand and the complexes possess moderate antimicrobial activity.

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