scholarly journals Desmoplastic fibroblastoma (collagenous fibroma) on the mandibular ridge: case report and review of immunohistochemical markers

2022 ◽  
Vol 63 (1) ◽  
Author(s):  
Pedro Isaias ◽  
◽  
Thâmara Bezerra ◽  
Filipe Chaves ◽  
Ana Alves ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Collagenous Fibroma ◽  
Desmoplastic Fibroblastoma ◽  
Immunohistochemical Markers ◽  
Oral Site ◽  
Elevated Lesion ◽  
Benign Soft Tissue Tumor ◽  
One Year

The desmoplastic fibroblastoma (DF) is a rare benign soft-tissue tumor of fibroblastic and myofibroblastic origin, and its occurrence in the oral cavity is rare. This study details a new case of an elevated lesion in the alveolar ridge of a 59-year-old woman, painful during mastication. The histopathological exam showed non-encapsulated stellate-to-spindle cells proliferation in a hypocellular collagen-rich stroma. Tumor cells were strongly and diffusely positive for vimentin, and some cells were focally positive for α-smooth muscle actin, CD99, and β-catenin. The exams were conclusive for DF diagnosis. The patient is in the follow-up period, and no recurrent lesions were detected within one year. Despite having similar clinical, pathological, and immunohistochemical features to the cases previously described, the DF in this report is at an unusual oral site and associated with painful symptomatology. Immunohistochemistry is an important tool in DF cases where the histopathological examination is not conclusive.

A Case of Incidentally Detected Bladder Lipoma and a Review of the Literature

2021 ◽  
Vol 17 ◽  
Author(s):  
Emre Emekli ◽  
Elif Gündoğdu
Keyword(s):  
Histopathological Examination ◽  
Adrenal Adenoma ◽  
Bladder Wall ◽  
Benign Tumors ◽  
Imaging Features ◽  
Multiplanar Reconstructions ◽  
Clinical Presentations ◽  
Pelvic Lipomatosis ◽  
One Year

Background: Lipomas are benign fatty tumors made of fat tissue. Bladder lipomas are extremely rare. For this reason, it is necessary to be aware of the imaging features when incidentally detected in imaging. Case Report: In the abdominal computed tomography (CT) performed as part of the follow-up examination of a 43-year-old patient, who had undergone surgery for adrenal adenoma five years earlier, a 14x9x8 mm smoothly marginated, ovoid-shaped, hypodense mass lesion with a homogeneous internal structure was detected in the anterior bladder wall. The pre-contrast density of the lesion was measured as -105 HU. The magnetic resonance imaging performed one year after the CT examination revealed a 14x9x8 intramural mass in the bladder wall, showing protrusion toward the lumen. The group was observed to be markedly hypointense on fat-suppressed T1 and T2-weighted images and considered consistent with a bladder lipoma. Discussion: Bladder lipomas are benign lesions that can vary in clinical presentations but usually cause hematuria. The differential diagnosis of bladder lipomas includes other mesenchymal rare benign tumors that can arise from the urinary bladder submucosal layer, including leiomyoma, hemangioma, plasmacytoma, fibroma, and neurofibroma, in imaging bladder lipomas present as homogeneous lesions containing macroscopic fat. Only the liposarcoma and pelvic lipomatosis could also show similar features. The less differentiated liposarcomas tend to present more heterogeneous enhancement, irregular-shaped margins, and infiltrative behavior. Also, appropriate multiplanar reconstructions may allow the radiologist to determine it is an extravesical pelvic lipomatosis. Conclusion: Using CT and MRI, these lesions rich in adipose tissue can be distinguished from other lesions, and their diagnosis can be made to a great extent. However, a histopathological examination is required for a definitive diagnosis.

scholarly journals Infantile Fibrosarcoma Histologically Mimicking a Benign Soft-Tissue Tumor

2020 ◽  
Vol 7 (4) ◽  
pp. 179-184
Author(s):  
Sam Hajialiloo Sami ◽  
◽  
Farshad Zandrahimi ◽  
Mohamadreza Heidarikhoo ◽  
Mahsa Zahmatkesh ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Vascular Lesion ◽  
Diagnostic Challenge ◽  
Soft Tissue Neoplasm ◽  
Infantile Fibrosarcoma ◽  
Inappropriate Treatment ◽  
Benign Soft Tissue Tumor ◽  
One Year

Infantile fibrosarcoma is a rare soft-tissue neoplasm, which may render a diagnostic challenge leading to misdiagnosis and consequently an inappropriate treatment of patients. This study reports a case of infantile fibrosarcoma that mimicked a hemangioma in an 11-month-old girl. As the lesion signal in the MRI was not consistent with the diagnosis of hemangiomas, we performed a core needle biopsy, which its result was consistent with the diagnosis of infantile fibrosarcoma. The lesion was initially treated with surgical resection. However, the lesion recurred one year after the surgery. The recurrence was managed with debulking surgery. The fifth finger was necrotized during the hospitalization after the relapse surgery. Finally, the necrotic finger was amputated. Also, adjuvant chemotherapy was used to prevent further relapses. The 1-year follow-up of the patient was recurrence-free. These findings highlight the importance of considering infantile fibrosarcoma when an infant presents with a lesion that clinically mimics a vascular lesion.

scholarly journals Intermammary pilonidal sinus: rare location of a common condition

2020 ◽  
Vol 8 (1) ◽  
pp. 385
Author(s):  
Gayatri A. Deshpande ◽  
Raj N. Gajbhiye ◽  
Bhupesh Tirpude ◽  
Hemant Bhanarkar ◽  
Vikrant Akulwar ◽  
...  
Keyword(s):  
Pilonidal Sinus ◽  
Primary Closure ◽  
Histopathological Examination ◽  
Skin Surface ◽  
Sinus Tract ◽  
Complete Excision ◽  
Rare Location ◽  
Keloid Formation ◽  
One Year

Pilonidal sinus in the intermammary region is a rare location of an inflammatory condition commonly occurring in the natal cleft. It is typically characterised by a pus and hair containing cavity in the skin lined by granulation tissue connecting the skin surface. A 22 year-old female presented with chronically discharging sinuses in the intermammary region with recurrent abscess formation for one year duration. Although a rare location, clinical diagnosis of pilonidal sinus was made. Complete excision of sinus tract with abscess cavity with primary closure was performed under general anaesthesia. Histopathological examination confirmed pilonidal sinus. On follow up, the scar was healthy with no keloid formation. Pilonidal sinus may rarely occur in intermammary region. Complete excision and primary closure is the mainstay treatment.

Childhood Desmoplastic Fibroblastoma (Collagenous Fibroma) with a 12-Year Follow-up

1999 ◽  
Vol 2 (1) ◽  
pp. 62-64 ◽  
Author(s):  
Gaetano Magro ◽  
Carmelo Venti
Keyword(s):  
Subcutaneous Tissue ◽  
Collagenous Fibroma ◽  
Desmoplastic Fibroblastoma ◽  
First Case ◽  
Left Buttock

We report the first case of a childhood desmoplastic fibroblastoma (collagenous fibroma). The tumor was located in subcutaneous tissue of the left buttock in a 5-year-old boy. No recurrence has been observed after 12 years, the longest follow-up available.

scholarly journals Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition

2016 ◽  
Vol 140 (6) ◽  
pp. 543-551 ◽  
Author(s):  
Joseph Sanfrancesco ◽  
Jesse K. McKenney ◽  
Mariah Z. Leivo ◽  
Sounak Gupta ◽  
Paul Elson ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Epithelial To Mesenchymal Transition ◽  
Smooth Muscle Actin ◽  
Mesenchymal Transition ◽  
Immunohistochemical Markers ◽  
Not Otherwise Specified ◽  
Cytokeratin 5 ◽  
Aggressive Tumor ◽  
Carcinoma Of The Bladder

Context.—Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. Objective.—To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-to-mesenchymal transition. Design.—Twenty-eight cases of sarcomatoid UCa were rereviewed. Clinical outcomes were obtained through database search. Immunohistochemistry for clinical and epithelial-to-mesenchymal transition markers was performed. Results.—All patients had biopsy-proven invasive UCa; 61% (17 of 28) had sarcomatoid UCa at initial diagnosis. A recognizable epithelial component(s) was present in 17 lesions. The sarcomatoid component accounted for 65% of the lesion (average), with heterologous elements present in 3 of 28 cases (11%). The morphologic spectrum of the sarcomatoid element included spindled not otherwise specified, myxoid, pseudoangiosarcomatous, and malignant fibrous histiocytoma–like undifferentiated features. The sarcomatoid component was immunoreactive for pancytokeratin (22 of 26; 85%), p63 (20 of 26; 77%), cytokeratin 903 (17 of 26; 65%), cytokeratin 7 (16 of 26; 62%), GATA3 (16 of 26; 62%), and cytokeratin 5/6 (16 of 26; 62%). STAT-6, CD31, CD34, and HMB45 were all nonreactive, whereas smooth muscle actin often showed at least focal immunoreactivity (22 of 26; 85%). Epithelial-to-mesenchymal transition markers were frequently expressed, including vimentin (26 of 26; 100%), FoxC2 (26 of 26; 100%), SNAIL (23 of 26; 88.5%), and ZEB1 (18 of 26; 69.2%). Follow-up was available for 24 patients (median, 7 months). Sixteen of 28 patients (57%) died of disease (overall mean survival, 9.1 months). The presence of myxoid or chordoid features was associated with reduced survival (P < .05). Conclusions.—Sarcomatoid UCa is an aggressive form of UCa that frequently expresses epithelial-to-mesenchymal transition markers, suggesting a possible mechanism associated with aggressive tumor behavior.

scholarly journals Giant Hypopharyngeal Fibrovascular Polyp: A Case Report and Review of the Relevant Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Suheyl Haytoglu ◽  
Birgul Tuhanioglu ◽  
Abdurrahman Bozkurttan ◽  
Osman Kursat Arikan
Keyword(s):  
Histopathological Examination ◽  
Relevant Literature ◽  
Normal Mucosa ◽  
Endoscopic Examination ◽  
Fibrous Stroma ◽  
Fibrovascular Polyp ◽  
Vascular Structures ◽  
One Year ◽  
Progressive Dysphagia

Fibrovascular polyps occur most commonly in the cervical esophagus and are extremely rare in the hypopharynx. In this paper, we report a case of fibrovascular polyp of a 52-year-old female, who presented with progressive dysphagia and weight loss and regurgitating a mass from her mouth. By the endoscopic examination, a polyp covered by normal mucosa with a wide stalk was detected at the hypopharynx. The pedicle of the mass was identified under general anesthesia and the 13 × 3 × 2 cm mass was completely resected perorally. Histopathological examination of the tumor showed oedematous subepithelial fibrous stroma, surrounded by squamous epithelium and containing many congested vascular structures. No recurrence was detected over one year of follow-up. This case highlights the need for clinicians to be aware of this rare entity and to develop the best approach to patient management.

scholarly journals Carcinoid tumour of appendixCarcinoid tumour of appendix

2021 ◽  
Vol 8 (7) ◽  
pp. 2169
Author(s):  
Abdul Rehman Siddiqui ◽  
Shrey Aren ◽  
Rajat Kumar Patra
Keyword(s):  
Abdominal Pain ◽  
Acute Appendicitis ◽  
Carcinoid Tumor ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Carcinoid Tumour ◽  
Recurrent Abdominal Pain ◽  
Benign Tumors ◽  
One Year

Carcinoid tumors are quite common neoplasm of the appendix. The clinical presentation of these lesions somewhat corelates to that of acute appendicitis, or the tumors are asymptomatic. The carcinoids are commonly found incidentally during histopathological examination of the resected appendix following appendectomy or other abdominal procedures. Appendiceal carcinoids usually behave as benign tumors and appendicectomy alone is a sufficient treatment in the majority of cases, while for larger lesions (lesions at the base of the appendix), right colectomy should be performed. The prognosis of patients with local appendiceal carcinoids is excellent. The present study reports the case of a 49-years-old male patient that presented with recurrent abdominal pain of 6 weeks duration. The patient underwent successful appendectomy and recovered four days later. Subsequently, an appendiceal carcinoid tumor located at the tip of the appendix was diagnosed by histopathological examination. Follow-up examination one year after surgery revealed that the patient was well with no discomfort.

scholarly journals Osteochondroma Involving the Ramus of the Mandible: An Unusual Location

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Pakki Suresh Kumar ◽  
Dola Srinivasa Rao ◽  
Swapna Manepalli ◽  
Ajit Damera ◽  
Jai Kiran Killada
Keyword(s):  
Histopathological Examination ◽  
Mouth Opening ◽  
Panoramic Radiograph ◽  
Axial Skeleton ◽  
Patient Reported ◽  
The Face ◽  
Magnetic Resonance Imaging Mri ◽  
One Year ◽  
The One

Osteochondroma (OC) is considered the most common tumor of the axial skeleton, although it is relatively uncommon in the craniofacial region. The present case describes an atypical case of OC in the posterior border of the ramus of the mandible. To the best of our knowledge, only one case has been reported till now in this region. A 35-year-old male patient reported with a complaint of swelling over the left middle one-third of the face and limited mouth opening for six years. Panoramic radiograph (PR) and paranasal sinus (PNS) view showed a well-defined radiopacity located in this region. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a characteristic mushroom-shaped outgrowth from the inner surface of the ramus of the mandible. The patient was treated with osteotomy, with the cut made at the angle of the mandible. Histopathological examination revealed features suggestive of OC. Subsequently, the patient was able to open his mouth, and there was no evidence of recurrence or postoperative complications in the one-year follow-up.

scholarly journals Spectrum of Surgical Presentation of Eosinophilic Enteritis

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Spoorthy Sudhakar Shetty ◽  
Charan Kishor Shetty
Keyword(s):  
Histopathological Examination ◽  
Past History ◽  
Case Series ◽  
Antitubercular Drugs ◽  
History Of ◽  
Subacute Intestinal Obstruction ◽  
Clinical Dilemma ◽  
One Year ◽  
Eosinophilic Gastrointestinal Disorders

Eosinophilic enteritis is a rare disorder presenting mostly with diarrhea, malabsorption, abdominal pain, weight loss, and hypersensitivity. Surgical manifestation of eosinophilic gastrointestinal disorders depends on the site and extent of involvement. In our case series of four patients two of them had ileocaecal masses with recurrent subacute intestinal obstruction with past history of intake of antitubercular drugs for 9 months. On histopathological examination both of them proved to have eosinophilic enterocolitis. Thus it is a clinical dilemma to differentiate between these two conditions. The other two patients presented as acute abdomen with perforation and intussusception. All four patients were treated surgically. Postoperatively they recovered well with no symptoms on one year follow-up. In Indian setup tuberculosis being rampant there may be under reporting or wrongly diagnosed cases of eosinophilic enteritis. Thus a strong clinical suspicion and awareness of this clinical entity are essential among surgical community.

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