scholarly journals ENDOSCOPIC PHOTODYNAMIC THERAPY OF A PATIENT WITH LUNG CANCER METASTASIS IN BIFURCATION LYMPH NODES (CLINICAL OBSERVATION)

2018 ◽  
Vol 7 (2) ◽  
pp. 50-54
Author(s):  
V. M. Legostaev ◽  
O. Yu. Babenkov ◽  
G. V. Balitskiy

AbstractThis clinical case demonstrates the feasibility of photodynamic therapy (PDT) as a method of choosing the treatment of recurrent lung cancer in inoperable patients with ineffective chemoradiotherapy. An operation was performed on the patient with a diagnosis of pT4N0M0 central cancer of the lower lobe of the right lung after 2 courses of neoadjuvant chemotherapy in October 2015: an expanded combined lower bilobectomy of the right lung, with resection of the pericardium and left atrium. Then 4 courses of adjuvant chemotherapy (cisplatin + vinorelbine) and a course of radiotherapy on the mediastinum area up to a total dose of 45 Gy were carried out. After 2 months, a metastatic lesion of bifurcation lymph nodes with invasion of the mucosa of the tracheal bifurcation, involving the distal trachea, proximal right and left main bronchi was detected. The result of histological analysis: G2 squamous cell carcinoma without keratinization. From Dec 2016 to Jun 2017, the patient underwent 5 courses of PDT, as a result of which a significant cytoreductive effect and stabilization of the process were achieved. The continuation of the PDT treatment is planned.

Surgery Today ◽  
1999 ◽  
Vol 29 (3) ◽  
pp. 238-242
Author(s):  
Masami Sato ◽  
Yasuki Saito ◽  
Hirokazu Aikawa ◽  
Akira Sakurada ◽  
Tatsuo Tanita ◽  
...  

2014 ◽  
Vol 68 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Fumihiro Ogawa ◽  
Hideki Amano ◽  
Yoshiya Ito ◽  
Yoshio Matsui ◽  
Kanako Hosono ◽  
...  

Surgery Today ◽  
1999 ◽  
Vol 29 (3) ◽  
pp. 238-242 ◽  
Author(s):  
Masami Sato ◽  
Yasuki Saito ◽  
Hirokazu Aikawa ◽  
Akira Sakurada ◽  
Motoyasu Sagawa ◽  
...  

1992 ◽  
Vol 16 (5) ◽  
pp. 986-993 ◽  
Author(s):  
Noritoshi Lee ◽  
Kiyotoshi Inoue ◽  
Ryoji Yamamoto ◽  
Hiroaki Kinoshita

2011 ◽  
Vol 44 (5) ◽  
pp. 591-596 ◽  
Author(s):  
Nicholas D. Walter ◽  
Pamela L. Rice ◽  
Elizabeth F. Redente ◽  
Emily F. Kauvar ◽  
Lisa Lemond ◽  
...  

Human Cell ◽  
2021 ◽  
Author(s):  
Yan Lu ◽  
Yushuang Zheng ◽  
Yuhong Wang ◽  
Dongmei Gu ◽  
Jun Zhang ◽  
...  

AbstractLung cancer is the most fetal malignancy due to the high rate of metastasis and recurrence after treatment. A considerable number of patients with early-stage lung cancer relapse due to overlooked distant metastasis. Circulating tumor cells (CTCs) are tumor cells in blood circulation that originated from primary or metastatic sites, and it has been shown that CTCs are critical for metastasis and prognosis in various type of cancers. Here, we employed novel method to capture, isolate and classify CTC with FlowCell system and analyzed the CTCs from a cohort of 302 individuals. Our results illustrated that FlowCell-enriched CTCs effectively differentiated benign and malignant lung tumor and the total CTC counts increased as the tumor developed. More importantly, we showed that CTCs displayed superior sensitivity and specificity to predict lung cancer metastasis in comparison to conventional circulating biomarkers. Taken together, our data suggested CTCs can be used to assist the diagnosis of lung cancer as well as predict lung cancer metastasis. These findings provide an alternative means to screen early-stage metastasis.


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