BARRIERS TO THE MANAGEMENT OF DIABETES MELLITUS - IS THERE A ROLE FOR LASER DOPPLER FLOWMETRY?

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler ﬂowmetry in children with diﬀerent experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler ﬂowmetry using a laser analyzer for capillary blood ﬂow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood ﬂow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac ﬂuctuations, low efciency and redistribution of blood ﬂow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the eﬀectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outﬂow.

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METHOD FOR ANALYSIS OF THE DOPPLER-BROADENED SPECTRA OF LASER RADIATION FOR THE ASSESSMENT OF BLOOD MICROCIRCULATION DISTURBANCES IN DIABETES MELLITUS TYPE 2

Fundamental and Applied Problems of Engineering and Technology ◽

10.33979/2073-7408-2020-342-4-1-80-87 ◽

2020 ◽

Vol 4 (1) ◽

pp. 80-87

Author(s):

I.O. KOZLOV

Keyword(s):

Diabetes Mellitus ◽

Laser Radiation ◽

Laser Doppler Flowmetry ◽

Diabetes Mellitus Type 2 ◽

Feature Space ◽

Diabetes Mellitus Type ◽

Laser Doppler ◽

Doppler Flowmetry ◽

New Feature

The article is devoted to the development of laser Doppler flowmetry and analysis of the recorded signal to study the distribution of perfusion over the frequencies of Doppler broadening of laser radiation. The processing algorithm and the necessary technical conditions for the correct registration of the signal are shown. As examples of the proposed method implementation, the data are obtained from a healthy volunteer and a patient with diabetes mellitus type 2 and analyzed. According to the proposed method, processing of recorded data provides a new feature space for data analysis of laser Doppler flowmetry signal.

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Diagnostic capabilities of different methods of laser doppler flowmetry spectral indexes assessment in patients with diabetic microangiopathy

Biomedical Photonics ◽

10.24931/2413-9432-2021-10-2-18-24 ◽

2021 ◽

Vol 10 (2) ◽

pp. 18-24

Author(s):

P. V. Vasilev ◽

N. P. Erofeev ◽

A. N. Shishkin

Keyword(s):

Diabetes Mellitus ◽

Laser Doppler Flowmetry ◽

Main Group ◽

Laser Doppler ◽

Diabetic Microangiopathy ◽

Control Group ◽

Spectral Parameters ◽

Doppler Flowmetry ◽

Diagnostic Capabilities ◽

And Control

The article contains the results of a study of two different methods for calculating the spectral parameters of laser Doppler flowmetry in patients with diabetic microangiopathy caused by type 2 diabetes mellitus (main group) and those with excluded diabetes mellitus (control group). Spectral indices were calculated using either average or maximum amplitudes of the frequency ranges. When comparing the contribution of respiratory and pulse fluxmotions using average amplitudes, there were significant (p < 0.05) differences between the main and control groups. On the contrary, when using the maximum amplitudes, no significant differences were noted (p > 0.05). Also, significant correlations were found between the contributions of respiratory and pulse fluxmotions and the estimated glomerular filtration rate in the main group, using both calculation methods. These studies indicate the feasibility of using a technique based on the analysis of average amplitudes to increase the specificity of laser Doppler flowmetry as a method for diagnosing diabetic microangiopathy.

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Evaluation of microangiopathy of the skin in patients with non-insulin-dependent diabetes mellitus by laser Doppler flowmetry; microvasodilatory responses to beraprost sodium

Diabetes Research and Clinical Practice ◽

10.1016/s0168-8227(97)01385-5 ◽

1997 ◽

Vol 36 (1) ◽

pp. 19-26 ◽

Cited By ~ 10

Author(s):

Yoshimasa Aso ◽

Toshihiko Inukai ◽

Yoshihiro Takemura

Keyword(s):

Diabetes Mellitus ◽

Laser Doppler Flowmetry ◽

Insulin Dependent Diabetes Mellitus ◽

Laser Doppler ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Doppler Flowmetry ◽

Beraprost Sodium ◽

Insulin Dependent

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Peculiarities of microcirculation in peridont tissues in children of key age groups sufficient type 1 diabetes. Part I

Periodontology ◽

10.25636/pmp.1.2019.1.1 ◽

2019 ◽

Vol 24 (1) ◽

pp. 4-10

Author(s):

B. N. Davydov ◽

D. A. Domenyk ◽

S. V. Dmitrienko

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Laser Doppler Flowmetry ◽

Laser Doppler ◽

Diabetic Microangiopathy ◽

Healthy Children ◽

Doppler Flowmetry

The relevance of the research topic. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders.Purpose – identifcation of microcirculation features of the blood by the method of laser Doppler ﬂowmetry in children with different experience of type 1 diabetes in key age categories.Methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler ﬂowmetry using a laser analyzer for capillary blood ﬂow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood ﬂow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac ﬂuctuations, low effciency and redistribution of blood ﬂow in favor of the nutritive link.Summary. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early - compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late - decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outﬂow.

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