scholarly journals Balancing Expressiveness and Inexpressiveness in View Design

Author(s):  
Michael Benedikt ◽  
Pierre Bourhis ◽  
Louis Jachiet ◽  
Efthymia Tsamoura

We study the design of data publishing mechanisms that allow a collection of autonomous distributed datasources to collaborate to support queries. A common mechanism for data publishing is via views: functions that expose derived data to users, usually specified as declarative queries. Our autonomy assumption is that the views must be on individual sources, but with the intention of supporting integrated queries. In deciding what data to expose to users, two considerations must be balanced. The views must be sufficiently expressive to support queries that users want to ask -- the utility of the publishing mechanism. But there may also be some expressiveness restriction. Here we consider two restrictions, a minimal information requirement, saying that the views should reveal as little as possible while supporting the utility query, and a non-disclosure requirement, formalizing the need to prevent external users from computing information that data owners do not want revealed. We investigate the problem of designing views that satisfy both an expressiveness and an inexpressiveness requirement, for views in a restricted declarative language (conjunctive queries), and for arbitrary views.

2021 ◽  
Vol 46 (4) ◽  
pp. 1-40
Author(s):  
Michael Benedikt ◽  
Pierre Bourhis ◽  
Louis Jachiet ◽  
Efthymia Tsamoura

We study the design of data publishing mechanisms that allow a collection of autonomous distributed data sources to collaborate to support queries. A common mechanism for data publishing is via views : functions that expose derived data to users, usually specified as declarative queries. Our autonomy assumption is that the views must be on individual sources, but with the intention of supporting integrated queries. In deciding what data to expose to users, two considerations must be balanced. The views must be sufficiently expressive to support queries that users want to ask—the utility of the publishing mechanism. But there may also be some expressiveness restrictions. Here, we consider two restrictions, a minimal information requirement, saying that the views should reveal as little as possible while supporting the utility query, and a non-disclosure requirement, formalizing the need to prevent external users from computing information that data owners do not want revealed. We investigate the problem of designing views that satisfy both expressiveness and inexpressiveness requirements, for views in a restricted information systems - query languages (conjunctive queries), and for arbitrary views.


Author(s):  
Dmitry Schigel ◽  
Anders Andersson ◽  
Andrew Bissett ◽  
Anders Finstad ◽  
Frode Fossøy ◽  
...  

Most users will foresee the use of genetic sequences in the context of molecular ecology or phylogenetic research, however, a sequence with coordinates and a timestamp is a valuable biodiversity occurrence that is useful in a much broader context than its original purpose. To uncover this potential, sequence-derived data need to become findable, accessible, interoperable, and reusable through generalist biodiversity data platforms. Stimulated by the Biodiversity_Next discussions in 2019, we have worked for about 10 months to put together practical data mapping and data publishing experiences in Norway, Australia, Sweden, and Denmark, as well as in the UNITE and the GBIF (Global Biodiversity Information Facility) networks. The resulting guide was put together to provide practical instruction for mapping sequence-derived data. Biodiversity data communities remain dominated by the macroscopic, easily detectable, morphologically identifiable species. This is not only true for citizen science and other forms of biodiversity popularization, but is also visible in the university and museum department structures, financial resource allocations, biodiversity legislation, and policy design. Recent decades of molecular advances have increased the power of genetic methods for detecting, describing, and documenting global biodiversity. We have yet to see the wide shift of data generating efforts from the traditional taxonomic foci of biodiversity assesments to the more balanced and inclusive systems focusing on all functionally important taxa and environments. These include soil, limnic and marine environments, decomposing plants and deadwood, and all life therein. Environmental DNA data enable recording of present and past presence of micro- and macroscopic organisms with minimal effort and by non-invasive methods. The apparent ease of these methods requires a cautious approach to the resulting data and their interpretation. It remains important to define and agree on the organism recording and reporting routines for genetic data. DNA data represent a major addition to the many ways in which GBIF and other biodiversity data platforms index the living world. Our guide is resting on the shoulders of those who have been developing and improving MIxS (Minimum Information about any (x) Sequence), GGBN (Global Genome Biodiversity Network) and other data standards. The added value of publishing sequence-derived data through non-genetic biodiversity discovery platforms relates to spatio-temporal occurrences and sequence-based names. Reporting sequence-derived occurrences in an open and reproducible way has a wide range of benefits: notably, it increases citability, highlights the taxa concerned in the context of biological conservation, and contributes to taxonomic and ecological knowledge.


Author(s):  
Yousef Binamer ◽  
Muzamil A. Chisti

AbstractKindler syndrome (KS) is a rare photosensitivity disorder with autosomal recessive mode of inheritance. It is characterized by acral blistering in infancy and childhood, progressive poikiloderma, skin atrophy, abnormal photosensitivity, and gingival fragility. Besides these major features, many minor presentations have also been reported in the literature. We are reporting two cases with atypical features of the syndrome and a new feature of recurrent neutropenia. Whole exome sequencing analysis was done using next-generation sequencing which detected a homozygous loss-of-function (LOF) variant of FERMT1 in both patients. The variant is classified as a pathogenic variant as per the American College of Medical Genetics and Genomics guidelines. Homozygous LOF variants of FERMT1 are a common mechanism of KS and as such confirm the diagnosis of KS in our patients even though the presentation was atypical.


Author(s):  
Yasir. B. Elshambaty

Purpose this study aims to show the patterns and outcome of pediatric injury among those living in Albaha region in Saudi Arabia Methods this is a cross-sectional descriptive household-based study, included children between 0-17 years old both male and female. The data were collected with structured questionnaire between 20 Nov – 20 Dec 2018 and  analyzed with SPSS version 25 Results the total of participants was 257 injured child. 199(77.4%) are male and 58(22.6%) are female. About 44%of them were injured at pre-school level and 56% were traumatized at school age. The least incidence of injury occurred in those less than 2 yrs and higher incidence in those between 3-10 yrs old. The most common mechanism of injury was falling from height. The most affected group age by RTA accidents was 11-17 yrs old. Approximately 83% of the injured children required hospital management. Only one third of the injuries were  associated complications. The most common injured anatomic part was the upper limb and the least affected part was the spine. Only 5% of the injuries were associated with a disability and the common was loss of organ or part of it. Paralysis occurred in less than 1% and head injury resulted in disabilities more than 1%. Conclusion the vast majority of the injuries in our participants are not serious. The severe injuries were associated with RTA-related trauma. Most of injuries due to falling from height are not serious. We recommend not to allow the children to drive cars. Keywords: pediatric injuries; injury patterns; household.


2017 ◽  
Author(s):  
Mohit S. Verma ◽  
Michael J. Fink ◽  
Gabriel L Salmon ◽  
Nadine Fornelos ◽  
Takahiro E. Ohara ◽  
...  

Two biological activities of butyrate in the colon (suppression of proliferation of colonic epithelial stem cells and inflammation) correlate with inhibition of histone deacetylases. Cellular and biochemical studies of molecules similar in structure to butyrate, but different in molecular details (functional groups, chain-length, deuteration, oxidation level, fluorination, or degree of unsaturation) demonstrated that these activities were sensitive to molecular structure, and were compatible with the hypothesis that butyrate acts by binding to the Zn<sup>2+</sup> in the catalytic site of histone deacetylases. Structure-activity relationships drawn from a set of 36 compounds offer a starting point for the design of new compounds targeting the inhibition of histone deacetylases. The observation that butyrate was more potent than other short-chain fatty acids is compatible with the hypothesis that crypts evolved (at least in part), to separate stem cells at the base of crypts from butyrate produced by commensal bacteria.


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