scholarly journals Research Protocol For A Pilot Study. The Effect Of ST (36) And Ren12 In The Control Of Hyperglycemia In Diabetic Patients

2020 ◽  
Vol 6 (6) ◽  
pp. 1-5
Author(s):  
Sánchez Ramírez Martín ◽  
Keyword(s):  
Pilot Study ◽  
Animal Models ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypoglycemic Effect ◽  
Diabetic Patients ◽  
Research Protocol ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Adrenal Cortical Hormone ◽  
Pituitary Adrenal Axis

These acupunture points stimulated with EA have shown their hypoglycemic effect in animal models. One of the main mechanisms by which this effect is supported is the regulation of the hypothalamic-pituitary-adrenal axis, regulating the secretion of adrenal cortical hormone.

scholarly journals Use of the Dexamethasone-Corticotrophin Releasing Hormone Test to Assess Hypothalamic-Pituitary-Adrenal Axis Function in Rheumatoid Arthritis

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Eman A. Hasan ◽  
David S. Jessop ◽  
Lynsey L. Power ◽  
Paul T. Monk ◽  
John R. Kirwan
Keyword(s):  
Rheumatoid Arthritis ◽  
Pilot Study ◽  
Plasma Cortisol ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Plasma Samples ◽  
Noninvasive Technique ◽  
Hypothalamic Pituitary Adrenal ◽  
Releasing Hormone ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Objectives. Hypothalamic-Pituitary-Adrenal axis function may be abnormal in rheumatoid arthritis (RA). A pilot study in 7 patients suggested impaired glucocorticoid feedback in some patients after the dexamethasone-corticotrophin releasing hormone (CRH) test. This study aimed to investigate the dexamethasone-corticotrophin releasing factor test in a larger group of patients and relate the results to characteristics of the disease.Methods. Outpatients with active RA (≥3 swollen and tender joints and C-reactive protein > 10 mg/L) took dexamethasone (1.5 mg) at 23:00 hour in the evening. Next day, baseline saliva and plasma samples were collected, CRH was infused at 11:00 hour, and 4 serial blood and saliva samples were collected. Plasma samples were stored at−80∘Cand a radioimmunoassay performed for saliva and plasma cortisol.Results. All 20 participants showed normal dexamethasone suppression and mounted no response to the CRH challenge. In samples with measurable cortisol, there was a strong correlation between saliva and plasma values (r= 0.876,n= 26,P<.01).Conclusion. No abnormalities were found in the Dexamethasone-CRH test in RA patients in contrast to a previous pilot study. Salivary cortisol measurement may offer an alternative noninvasive technique to plasma cortisol in RA patients in future studies.

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