scholarly journals Dermal Irritation Study of Pankajakasthuri Orthoherb Cream/Thermagel, a Potent Polyherbal Anti-inflammatory and Analgesic Formulation for Topical Application in Healthy New Zealand White Rabbits

2021 ◽  
Vol 5 (1) ◽  
pp. 1-7
Author(s):  
Sasidharan S ◽  
Keyword(s):  
New Zealand ◽  
Topical Application ◽  
Scoring System ◽  
Skin Irritation ◽  
Application Site ◽  
Repeated Application ◽  
Skin Reactions ◽  
Topical Medication ◽  
Dermal Irritation ◽  
New Zealand White Rabbits

Pankajakasthuri orthoherb cream/thermagel is a polyherbal topical medication formulated for managing inflammation and pain. The objective of the present study was to evaluate the skin irritation potential of Pankajakasthuri orthoherb cream/thermagel on a single and repeated application in New Zealand white rabbits. The rabbits were dermally exposed with Pankajakasthuri orthoherb cream/thermagel and the appearance of each application site at 1 h, 24 h, 48 h, 72 h, 7th day and 14th day was recorded. The dermal reactions (erythema and edema) were evaluated according to the skin reactions scoring system. Pankajakasthuri orthoherb

Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits

Toxicology ◽  
1979 ◽  
Vol 14 (2) ◽  
pp. 117-130 ◽  
Author(s):  
James C. Murphy ◽  
E.S. Watson ◽  
P.W. Wirth ◽  
Paul Skierkowski ◽  
R.M. Folk ◽  
...  
Keyword(s):  
New Zealand ◽  
Topical Application ◽  
Antineoplastic Agents ◽  
New Zealand White Rabbits

scholarly journals Standardadization and skin irritation potential of herbal analgesic cream containing Nigella sativa seed oil

2019 ◽  
Vol 19 (1) ◽  
pp. 163-168
Author(s):  
Tehmina Sohail ◽  
Shazia Yasmeen ◽  
Hina Imran ◽  
Sadia Ferheen ◽  
Atiq U Rehman ◽  
...  
Keyword(s):  
Patch Testing ◽  
Hplc Analysis ◽  
Nigella Sativa ◽  
Skin Irritation ◽  
Medical Science ◽  
Skin Reactions ◽  
Nigella Sativa Oil ◽  
Dermal Irritation ◽  
Irritation Test ◽  
Skin Irritation Test

Background & Objective: The aim of present study was to evaluate herbal analgesic cream containing Nigella sativa oil as an active ingredient, standardization of Nigella sativa oil and evaluation of irritation/sensitization potential of formulation. Material & Method: For this, HPLC analysis of oil, skin irritation test on rabbits and patch testing on human skin was conducted. HPLC analysis using C-18 column, using an isocratic mobile phase of water: methanol (10:90) at flow rate of 1 ml/inactive ingredient: thymoquinone purified from the oil was found to be 1.42g (28.4 %). Safety assessment of analgesic cream was based on Primary Dermal Irritation Index (PDII) by Draize method. Result: According to Draize standard scoring system of reactions PDII was found 0.04 which comes under the category of non irritant. Patch testing on human volunteers revealed that none of volunteers showed any sign of skin reactions. Bangladesh Journal of Medical Science Vol.19(1) 2020 p.163-168

scholarly journals A Study for Expanding Application Sites for Rotigotine Transdermal Patch

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Hitoshi Kujirai ◽  
Sakiko Itaya ◽  
Yumi Ono ◽  
Makoto Takahashi ◽  
Akira Inaba ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Skin Irritation ◽  
Application Site ◽  
Transdermal Patch ◽  
Skin Reactions ◽  
Disease Rating ◽  
Rotigotine Transdermal Patch ◽  
The Mean

The rotigotine transdermal patch (RTP) is a dopamine agonist used to treat Parkinson’s disease (PD). Some PD patients cannot continue RTP treatment due to application site reactions. We explored sites for RTP where application site reactions are less severe than those in the six approved application sites. Thirty PD patients (12 men, mean age = 76 years) who underwent RTP at the approved sites and had some application site reactions were enrolled in this study. When applying the RTP to the approved application sites for more than four weeks (pre-RTP) and then on the shin for the following four weeks (post-RTP), skin reactions, itching evaluated using the skin irritation score, motor symptoms, clinical global impressions scale, and plasma rotigotine concentration were examined. The mean visual analogue scale and skin irritation score in the post-RTP group were significantly lower than those in the pre-RTP group. The mean Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III score in the post-RTP group was slightly but significantly lower than that in the pre-RTP group. Plasma rotigotine concentration in the post-RTP group was slightly but significantly lower than that in the pre-RTP group. These results indicate that the shin can be a useful application site for RTP.

scholarly journals Developing a Simple 3-Day Insulin Delivery Device to Meet the Needs of People With Type 2 Diabetes

2018 ◽  
Vol 13 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Leslie C. Lilly ◽  
Julia K. Mader ◽  
Jay Warner
Keyword(s):  
Glycemic Control ◽  
Human Factors ◽  
Health Care Providers ◽  
Clinical Studies ◽  
Skin Irritation ◽  
Insulin Delivery ◽  
Application Site ◽  
Care Providers ◽  
Delivery Device ◽  
Dermal Irritation

Aim: We sought to design an insulin delivery method that would overcome barriers to insulin therapy and meet the needs of the users, adults with diabetes, and their health care providers (HCPs). Methods: We conducted focus groups and human factors studies with users to learn about their needs and requirements. We then designed an insulin delivery device, PAQ, with features that met the user’s requirements. Iterative design and human factors testing (HFT) was performed with adults with diabetes on ⩾2 injections/day and HCPs. In parallel, studies were conducted to identify an adhesive that stayed adhered for 3 days and caused minimal, if any, dermal irritation. Pilot clinical studies were then initiated. Results: Users want a way to administer insulin that is simple, discreet, safe, and effective. A summative HFT found the device was easy to learn and use. All participants (30/30, 100%) successfully completed the key performance measures tested. An adhesive validation study in 30 adults with diabetes found 90% of the devices remained adhered to the participant’s application site at the end of 3 days with minimal skin irritation. Data from 3 clinical studies revealed 74-75% transitioned from injectable insulin to the device with the first fixed basal rate selected, improved glycemic control, and participants’ satisfaction with the device. Conclusion: The collective data from the HFT, adhesive, and clinical studies demonstrated that the device provides a method of insulin delivery that overcomes barriers to injectable insulin, meets the needs of the user, and achieves glycemic control.

Acute Dermal Irritation Study of JP-8 and S-8 in New Zealand White Rabbits

2011 ◽  
Author(s):  
Jonathan M. Hurley ◽  
Dean Wagner ◽  
Teresa R. Sterner ◽  
David R. Mattie
Keyword(s):  
New Zealand ◽  
Dermal Irritation ◽  
New Zealand White Rabbits

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

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