B7-H3 expression in children with asthma exacerbation

2015 ◽  
Vol 36 (4) ◽  
pp. 37-43 ◽  
Author(s):  
Zhengrong Chen ◽  
Guangbo Zhang ◽  
Yuqing Wang ◽  
Yongdong Yan ◽  
Canhong Zhu ◽  
...  
2021 ◽  
Author(s):  
Po‐Yang Tsou ◽  
Christopher Cielo ◽  
Melissa S. Xanthopoulos ◽  
Yu‐Hsun Wang ◽  
Pei‐Lun Kuo ◽  
...  

2002 ◽  
Vol 109 (3) ◽  
pp. 440-445 ◽  
Author(s):  
Stefania Zanconato ◽  
Massimo Scollo ◽  
Cristina Zaramella ◽  
Linda Landi ◽  
Franco Zacchello ◽  
...  

CHEST Journal ◽  
2010 ◽  
Vol 137 (2) ◽  
pp. 348-354 ◽  
Author(s):  
Ting Fan Leung ◽  
Man Yin To ◽  
Apple C.M. Yeung ◽  
Yun Sze Wong ◽  
Gary W.K. Wong ◽  
...  

2017 ◽  
Vol 90 (2) ◽  
pp. 219-228 ◽  
Author(s):  
Shou-Yan Zheng ◽  
Li-Li Wang ◽  
Luo Ren ◽  
Jian Luo ◽  
Wei Liao ◽  
...  

2018 ◽  
Vol 66 (8) ◽  
pp. 1102-1108 ◽  
Author(s):  
Noussa Ragab El Basha ◽  
Hanan Mohsen Osman ◽  
Amaal Abdo Abdelaal ◽  
Salma Mohamed Saed ◽  
Hala Hamdy Shaaban

Children with severe asthma or acute asthma exacerbation may encounter difficulties in performing pulmonary function tests. In this situation, serum biomarkers can play a great role in evaluation of such patients. The aim of this study was to estimate the serum levels of human chitinase-3-like protein 1 (YKL40) and periostin in a group of Egyptian children with asthma during acute asthma exacerbation and in stable asthmatics compared with healthy control, and to correlate these findings with the severity of asthma. This cross-sectional study enrolled 120 childrenwith asthma with different degrees of asthma severity, according to the Global Initiative for Asthma guidelines, along with 60 age-matched and sex-matched healthy control. A complete blood count and an estimation of serum periostin and YKL40 levels were performed for all cases and control. Individual and mean values of periostin and YKL40 were significantly higher during acute asthma exacerbations, p<0.001. A highly significant relation between serum levels of periostin and YKL40 and asthma severity, p value for each was <0.001. Absolute eosinophil count was significantly correlated with the serum periostin levels in stable asthmatic group (p=0.01) only. There was significantly positive correlation (P<0.001) between both markers in stable asthmatic group. Spearman’s correlation coefficient shows a statistically significant positive correlation between both markers and patient’s age and duration of asthma, p value for each was 0.001. These findings highlight the importance of periostin and YKL40 as serum biomarkers for assessment of asthma severity and acute asthma exacerbations in children with asthma.


2016 ◽  
Vol 10 (3) ◽  
pp. 154-160 ◽  
Author(s):  
Joel A. Vazquez‐Perez ◽  
Jose E. Ramirez‐Gonzalez ◽  
Yazmin Moreno‐Valencia ◽  
Victor A. Hernandez‐Hernandez ◽  
Jose A. I. Romero‐Espinoza ◽  
...  

Author(s):  
Ela Beyyumi ◽  
Mohamed Tawil ◽  
Huda AlDhanhani ◽  
Sara Jameel ◽  
Manal Mouhssine ◽  
...  

Background: Risks of cancer have become more notable lately, especially for young children with a chronic condition such as atopy. This study reports on cumulative radiation from chest radiographs in children with asthma. Its main aims were to consider our current practice, and suggest minimizing chest radiograph use in this vulnerable people. Methods: The study was retrospective and conducted at tertiary center. Eligibility criteria included children 2-15 y who were admitted between January-2017 and December-2018 for asthma management. Results: Of 643 children who were admitted as ‘asthma exacerbation’, 243 (40% females; age [mean±SD] 5.4±3.3 y) met the study criteria for inclusion. Ninety-two (38%) children had temperature 38.8±0.7oC on the day of admission. Antibiotics were prescribed for 148 (61%) children, mainly for presumed pneumonia. Chest radiographs were requested for 214 (88%) children, mainly on the day of admission. Only 38 (18%) chest radiographs showed focal/multifocal pneumonia justifying antibiotic use. Significant predictors for requesting chest radiographs were antibiotic use for presumed pneumonia, lower oxygen saturation at presentation, and requesting blood culture. Rate of chest radiographs per year was negatively related to child’s age; the younger the child the higher the rate (model coefficient -0.259, P<0.001). For children <5 y, rate of chest radiographs was 1.39±1.21/y and radiation dose 0.028±0.025 mSV/y. The corresponding rates for children ≥5 y were 0.78±0.72/y and 0.008±0.007 mSV/y, respectively (P<0.001). Conclusion: Chest radiographs were commonly requested for children with asthma, especially the young ones. Prospective studies are necessary to measure the impact of this practice on their health.


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