Kinetic interrogation of substrate binding and transport in the serotonin transporter

2015 ◽  
Vol 3 (Suppl. 2) ◽  
pp. A2.20
Author(s):  
Peter S. Hasenhuetl
Keyword(s):  
Serotonin Transporter ◽  
Substrate Binding

scholarly journals A Dualistic Conformational Response to Substrate Binding in the Human Serotonin Transporter Reveals a High Affinity State for Serotonin

2015 ◽  
Vol 290 (12) ◽  
pp. 7747-7755 ◽  
Author(s):  
Henriette Bjerregaard ◽  
Kasper Severinsen ◽  
Saida Said ◽  
Ove Wiborg ◽  
Steffen Sinning
Keyword(s):  
Serotonin Transporter ◽  
Substrate Binding ◽  
High Affinity

scholarly journals Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations

2011 ◽  
Vol 18 (3) ◽  
pp. 1073-1085 ◽  
Author(s):  
Mari Gabrielsen ◽  
Aina Westrheim Ravna ◽  
Kurt Kristiansen ◽  
Ingebrigt Sylte
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Serotonin Transporter ◽  
Substrate Binding ◽  
Dynamics Simulations

Fibronexus-Like Adhesion Sites are Present at the Invasive Zones of Human Epidermoid Carcinomas

1982 ◽  
Vol 40 ◽  
pp. 106-109
Author(s):  
Irwin I. Singer
Keyword(s):  
Cell Cycle ◽  
Serum Concentration ◽  
Substrate Binding ◽  
High Serum ◽  
Adhesion Sites ◽  
Substrate Adhesion ◽  
Focal Contacts ◽  
Adhesion Complex ◽  
Low Serum

Our previous results indicate that two types of fibronectin-cytoskeletal associations may be formed at the fibroblast surface: dorsal matrixbinding fibronexuses generated in high serum (5% FBS) cultures, and ventral substrate-adhering units formed in low serum (0.3% FBS) cultures. The substrate-adhering fibronexus consists of at least vinculin (VN) and actin in its cytoplasmic leg, and fibronectin (FN) as one of its major extracellular components. This substrate-adhesion complex is localized in focal contacts, the sites of closest substratum approach visualized with interference reflection microscopy, which appear to be the major points of cell-tosubstrate adhesion. In fibroblasts, the latter substrate-binding complex is characteristic of cultures that are arrested at the G1 phase of the cell cycle due to the low serum concentration in their medium. These arrested fibroblasts are very well spread, flattened, and immobile.

Contributions of the substrate-binding arginine residues to maleate-induced closure of the active site of Escherichia coli aspartate aminotransferase

2001 ◽  
Vol 268 (6) ◽  
pp. 1640-1645
Author(s):  
Annelise Matharu ◽  
Hideyuki Hayashi ◽  
Hiroyuki Kagamiyama ◽  
Bruno Maras ◽  
Robert A. John
Keyword(s):  
Escherichia Coli ◽  
Active Site ◽  
Aspartate Aminotransferase ◽  
Substrate Binding ◽  
Arginine Residues

The serotonin transporter gene and stress reactivity in daily life

2007 ◽  
Author(s):  
Tamlin Conner ◽  
Kathleen C. Gunthert ◽  
Stephen Armeli ◽  
Howard Tennen ◽  
Jonathan Covault ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Stress Reactivity ◽  
Daily Life ◽  
Serotonin Transporter Gene ◽  
Transporter Gene
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