scholarly journals Peculiarities of influence of single intragastric administration of H2-histamine receptor blockers of the second (nisatidine) and third (famotidine) generation on acid-peptic and mucoid-electrolyte secretion of the stomach in patients with duodenal ulcer

2019 ◽  
Vol 4 (28) ◽  
pp. 39-50
Author(s):  
M. Pliatsko ◽  
Keyword(s):  
Duodenal Ulcer ◽  
Histamine Receptor ◽  
Intragastric Administration ◽  
Receptor Blockers ◽  
Electrolyte Secretion

scholarly journals Effectiveness of symptomatic treatment of ARI in children

2021 ◽  
pp. 72-77
Author(s):  
Anita R. Denisova
Keyword(s):  
Nasal Congestion ◽  
Interleukin 2 ◽  
Young Patients ◽  
Pain Syndrome ◽  
Symptomatic Treatment ◽  
Histamine Receptor ◽  
Nasal Discharge ◽  
Pathogenetic Therapy ◽  
Acute Respiratory Diseases ◽  
Receptor Blockers

Acute respiratory diseases (ARIs), a group of infectious diseases with similar epidemiological and clinical characteristics, are the most common reason for seeking medical care, children skipping attendance of educational institutions and parents skipping work. The clinical picture of ARI is characterized by a combination of the following symptoms: increased body temperature, nasal discharge, mostly mucous, nasal congestion, sore or scratchy throat and cough. In some cases, myalgia and manifestations of asthenia such as weakness, rapid fatigue, headache and decreased appetite may be noted. Pathogenetic therapy of ARI is based on clinical syndromes and includes symptomatic, antiviral and antibacterial drugs, also mucolytics, expectorants, cough suppressants; H1-histamine receptor blockers and immunocorrectors if necessary. Hyperthermia is the most significant problem faced by parents of young patients and pediatricians when dealing with ARI. The production of interferon gamma, interleukin-2 and tumor necrosis factor, which stimulate the production of IgG, is significantly increased with fever. Therefore, it is especially important to know the algorithms of behavior and criteria for understanding when and what antipyretics should be prescribed to a child. Administration of antipyretics for fever is aimed not only at stopping the fever, but also to improve the child’s wellbeing and reduce the pain syndrome during ARI. When choosing antipyretics, it is necessary to consider the age of the child, the preferred method of administration, the allowable doses, the frequency of administration, the prevention of complications in children at risk. Antipyretics may be prescribed in the form of combined drugs, not only able to reduce fever, but also eliminate other symptoms that occur against the background of acute respiratory infection.

Hepatitis following Treatments with Famotidine and Then CimetIDINE

1994 ◽  
Vol 28 (1) ◽  
pp. 37-39 ◽  
Author(s):  
Fred Hashimoto ◽  
Robin L. Davis ◽  
Douglas Egli
Keyword(s):  
Computed Tomography ◽  
Duodenal Ulcer ◽  
Fatty Liver ◽  
Obese Woman ◽  
Abdominal Ultrasound ◽  
Drug Discontinuation ◽  
Computed Tomography Scan ◽  
Case Summary ◽  
Receptor Blockers ◽  
Tomography Scan

OBJECTIVE: To report a case of hepatitis induced by two histamine (H2)-receptor blockers, famotidine and cimetidine. CASE SUMMARY: A 51-year-old obese woman with a duodenal ulcer developed symptomatic, famotidine-induced hepatitis. Other causes for hepatitis were ruled out. Famotidine was discontinued and the patient took omeprazole for a month without incident. Cimetidine therapy was then initiated and shortly thereafter, the patient developed another episode of symptomatic hepatitis that resolved upon drug discontinuation. Two abdominal ultrasound examinations six months apart and an abdominal computed tomography scan obtained later showed what appeared to be a stable, fatty liver. DISCUSSION: This appears to be the first reported case of clinical hepatitis related to famotidine and the first reported case where clinical hepatitis followed the administration of two different H2-receptor blockers. The fatty liver probably was secondary to obesity and incidental to the hepatitis episodes. CONCLUSIONS: Famotidine can cause clinical hepatitis, and druginduced hepatitis can occur after the administration of two different H2-receptor blockers.

scholarly journals Study of Antibody-Dependent Reactions of Mast Cells In Vitro and in a Model of Severe Influenza Infection in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Andrey Mamontov ◽  
Igor Losev ◽  
Dmitrii Korzhevskii ◽  
Valeriia Guselnikova ◽  
Alexander Polevshchikov ◽  
...  
Keyword(s):  
Mast Cells ◽  
Immune Complex ◽  
H5n1 Virus ◽  
Influenza Infection ◽  
Histamine Receptor ◽  
H1n1 Influenza ◽  
Influenza Viruses ◽  
Blue Staining ◽  
Receptor Blockers

We investigated the reaction of mouse peritoneal mast cells (MCs) in vitro after IgG-containing immune complex introduction using A/H5N1 and A/H1N1pdm09 influenza viruses as antigens. The sera of immune mice served as a source of IgG antibodies. The concentration of histamine in the supernatants was determined at 4 hours after incubation with antisera and virus. We compared the contribution of MCs to the pathogenesis of post-immunization influenza infection with A/H5N1 and A/H1N1 influenza viruses in mice. The mice were immunized parenterally with inactivated viruses and challenged with lethal doses of drift A/H5N1 and A/H1N1 influenza viruses on the 14th day after immunization. Simultaneously, half of the mice were injected intraperitoneally with a mixture of histamine receptor blockers (chloropyramine and quamatel). In in vitro experiments, the immune complex formed by A/H5N1 virus and antiserum caused a significant increase in the histamine release compared to immune serum or the virus alone. With regard to the A/H1N1 virus, such an increase was not significant. A/H1N1 immunization caused detectable HI response in mice at 12th day after immunization, in contrast to the A/H5N1 virus. After challenge of A/H5N1-immunized mice, administration of antihistamines increased the survival rate by up to 90%. When infecting the A/H1N1-immunized mice, 90% of the animals were already protected from lethal infection by day 14; the administration of histamine receptor blockers did not increase survival. Histological examination of the lungs has shown that toluidine blue staining allows to estimate the degree of MC degranulation. The possibility of in vitro activation of murine MCs by IgG-containing immune complexes has been shown. In a model of influenza infection, it was shown that the administration of histamine receptor blockers increased survival. When the protection was formed faster due to the earlier production of HI antibodies, the administration of histamine receptor blockers did not significantly affect the course of the infection. These data allow to propose that even if there are antibody-dependent MC reactions, they can be easily stopped by the administration of histamine receptor blockers.

scholarly journals Antihistamine therapy in pediatric practice

2018 ◽  
pp. 136-139 ◽  
Author(s):  
S. V. Tsarev
Keyword(s):  
First Generation ◽  
Allergic Diseases ◽  
Histamine Receptor ◽  
Receptor Blockers ◽  
Paediatric Practice ◽  
The Difference ◽  
And Function ◽  
First And Second Generation ◽  
Role And Function

The article considers the role of histamine in the pathogenesis of allergic diseases and other pathological conditions. The mechanisms that contribute to the development of skin itching are considered separately. The article also shows the role and function of H1-histamine receptor blockers in the treatment of allergic diseases and pseudo allergic reactions. The mechanism of action, indications, contraindications and side effects of the antihistamine therapy are presented. The article also discusses the difference in first and second-generation antihistamines and shows the possible advantages of the first-generation drugs in paediatric practice. The article presents data on the use of dimethindene maleate (Fenistil) in children’s practice, including the use for the relief of skin itching of various genesis.

Combined therapy for treatment of acute respiratory viral infections: analysis of combined complex AnviMax

2020 ◽  
pp. 33-48
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin
Keyword(s):  
Viral Infections ◽  
Respiratory Infections ◽  
Combined Therapy ◽  
Allergic Inflammation ◽  
Histamine Receptor ◽  
Receptor Blockers ◽  
Respiratory Viral Infections ◽  
Comprehensive Programs ◽  
Viral Respiratory Infections ◽  
Viral Respiratory

The annual increase in the incidence of influenza, SARS, and the COVID‑19 pandemic indicate the need for comprehensive programs to support congenital antiviral immunity. To increase the effectiveness of the treatment of viral respiratory infections, it is important to attenuate the effects of the so-called cytokine storm and enhanced compensation of the patient’s comorbid pathologies. Increasing the availability of zinc, vitamin C and rutoside can improve the body’s resistance to viral infections. In addition to micronutrients, to reduce the activity of allergic inflammation, second-generation H1-histamine receptor blockers (loratadine, etc.) and calcium gluconate can be used. To lower the  temperature, it is important to include paracetamol in therapy.

scholarly journals The effect of sleep disorders on health and the possibility of correction of sleep disorders

2018 ◽  
pp. 30-33 ◽  
Author(s):  
S. L. Tsenteradze ◽  
M. G. Poluektov
Keyword(s):  
Sleep Disorders ◽  
Gaba Receptors ◽  
Negative Impact ◽  
Histamine Receptor ◽  
Behavioural Therapy ◽  
Medicinal Products ◽  
Immunodeficiency Disorder ◽  
Cognitive Behavioural ◽  
Significant Negative Impact ◽  
Receptor Blockers

Treatment of insomnia is an important medical and social problem due to its widespread prevalence and significant negative impact on human health. The state of chronic cerebral hyper-activation, which has cognitive, electrophysiological and metabolic manifestations, plays an important role in the development of insomnia. The sleep disorder has been proven to be a risk factor for the development of arterial hypertension, metabolic syndrome, immunodeficiency disorder and cognitive impairment. Nonmedicinal and medicinal products are used to treat insomnia. Cognitive-behavioural therapy may be effective as a psychotherapy.  Non-benzodiazepine GABA-receptors agonists are most often used to treat chronic insomnia and histamine receptor blockers to treat acute insomnia among the other drugs of this group.

Bedtime treatment of duodenal ulcer

1985 ◽  
Vol 23 (24) ◽  
pp. 95-96
Keyword(s):  
Duodenal Ulcer ◽  
Clinical Trials ◽  
Drug Treatment ◽  
First Line ◽  
Ranitidine 300Mg ◽  
Receptor Blockers ◽  
Line Drug

Histamine H2-receptor blockers remain the first-line drug treatment for duodenal ulcer. Cimetidine (Tagamet) was introduced in 1976 in a four times daily dosage, and ranitidine (Zantac) in 1981 in a twice daily dosage. Clinical trials have shown that the drugs are similarly effective given twice daily.1 Recently, however, treatment with a single bedtime dose of cimetidine (800mg) or ranitidine (300mg) has been advocated for the healing of duodenal ulcer. Is this simple regimen as effective as the established twice daily dosage?

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