Mechanisms of histamine-induced increase of calcium level in cardiomyocytes. A relative efficacy of histamine receptor blockers

1997 ◽  
Vol 123 (4) ◽  
pp. 357-359 ◽  
Author(s):  
A. I. Khankoeva ◽  
A. S. Dukhanin ◽  
P. A. Galenko-Yaroshevskii
Keyword(s):  
Calcium Level ◽  
Histamine Receptor ◽  
Relative Efficacy ◽  
Receptor Blockers

scholarly journals Effectiveness of symptomatic treatment of ARI in children

2021 ◽  
pp. 72-77
Author(s):  
Anita R. Denisova
Keyword(s):  
Nasal Congestion ◽  
Interleukin 2 ◽  
Young Patients ◽  
Pain Syndrome ◽  
Symptomatic Treatment ◽  
Histamine Receptor ◽  
Nasal Discharge ◽  
Pathogenetic Therapy ◽  
Acute Respiratory Diseases ◽  
Receptor Blockers

Acute respiratory diseases (ARIs), a group of infectious diseases with similar epidemiological and clinical characteristics, are the most common reason for seeking medical care, children skipping attendance of educational institutions and parents skipping work. The clinical picture of ARI is characterized by a combination of the following symptoms: increased body temperature, nasal discharge, mostly mucous, nasal congestion, sore or scratchy throat and cough. In some cases, myalgia and manifestations of asthenia such as weakness, rapid fatigue, headache and decreased appetite may be noted. Pathogenetic therapy of ARI is based on clinical syndromes and includes symptomatic, antiviral and antibacterial drugs, also mucolytics, expectorants, cough suppressants; H1-histamine receptor blockers and immunocorrectors if necessary. Hyperthermia is the most significant problem faced by parents of young patients and pediatricians when dealing with ARI. The production of interferon gamma, interleukin-2 and tumor necrosis factor, which stimulate the production of IgG, is significantly increased with fever. Therefore, it is especially important to know the algorithms of behavior and criteria for understanding when and what antipyretics should be prescribed to a child. Administration of antipyretics for fever is aimed not only at stopping the fever, but also to improve the child’s wellbeing and reduce the pain syndrome during ARI. When choosing antipyretics, it is necessary to consider the age of the child, the preferred method of administration, the allowable doses, the frequency of administration, the prevention of complications in children at risk. Antipyretics may be prescribed in the form of combined drugs, not only able to reduce fever, but also eliminate other symptoms that occur against the background of acute respiratory infection.

scholarly journals Study of Antibody-Dependent Reactions of Mast Cells In Vitro and in a Model of Severe Influenza Infection in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Andrey Mamontov ◽  
Igor Losev ◽  
Dmitrii Korzhevskii ◽  
Valeriia Guselnikova ◽  
Alexander Polevshchikov ◽  
...  
Keyword(s):  
Mast Cells ◽  
Immune Complex ◽  
H5n1 Virus ◽  
Influenza Infection ◽  
Histamine Receptor ◽  
H1n1 Influenza ◽  
Influenza Viruses ◽  
Blue Staining ◽  
Receptor Blockers

We investigated the reaction of mouse peritoneal mast cells (MCs) in vitro after IgG-containing immune complex introduction using A/H5N1 and A/H1N1pdm09 influenza viruses as antigens. The sera of immune mice served as a source of IgG antibodies. The concentration of histamine in the supernatants was determined at 4 hours after incubation with antisera and virus. We compared the contribution of MCs to the pathogenesis of post-immunization influenza infection with A/H5N1 and A/H1N1 influenza viruses in mice. The mice were immunized parenterally with inactivated viruses and challenged with lethal doses of drift A/H5N1 and A/H1N1 influenza viruses on the 14th day after immunization. Simultaneously, half of the mice were injected intraperitoneally with a mixture of histamine receptor blockers (chloropyramine and quamatel). In in vitro experiments, the immune complex formed by A/H5N1 virus and antiserum caused a significant increase in the histamine release compared to immune serum or the virus alone. With regard to the A/H1N1 virus, such an increase was not significant. A/H1N1 immunization caused detectable HI response in mice at 12th day after immunization, in contrast to the A/H5N1 virus. After challenge of A/H5N1-immunized mice, administration of antihistamines increased the survival rate by up to 90%. When infecting the A/H1N1-immunized mice, 90% of the animals were already protected from lethal infection by day 14; the administration of histamine receptor blockers did not increase survival. Histological examination of the lungs has shown that toluidine blue staining allows to estimate the degree of MC degranulation. The possibility of in vitro activation of murine MCs by IgG-containing immune complexes has been shown. In a model of influenza infection, it was shown that the administration of histamine receptor blockers increased survival. When the protection was formed faster due to the earlier production of HI antibodies, the administration of histamine receptor blockers did not significantly affect the course of the infection. These data allow to propose that even if there are antibody-dependent MC reactions, they can be easily stopped by the administration of histamine receptor blockers.

scholarly journals Antihistamine therapy in pediatric practice

2018 ◽  
pp. 136-139 ◽  
Author(s):  
S. V. Tsarev
Keyword(s):  
First Generation ◽  
Allergic Diseases ◽  
Histamine Receptor ◽  
Receptor Blockers ◽  
Paediatric Practice ◽  
The Difference ◽  
And Function ◽  
First And Second Generation ◽  
Role And Function

The article considers the role of histamine in the pathogenesis of allergic diseases and other pathological conditions. The mechanisms that contribute to the development of skin itching are considered separately. The article also shows the role and function of H1-histamine receptor blockers in the treatment of allergic diseases and pseudo allergic reactions. The mechanism of action, indications, contraindications and side effects of the antihistamine therapy are presented. The article also discusses the difference in first and second-generation antihistamines and shows the possible advantages of the first-generation drugs in paediatric practice. The article presents data on the use of dimethindene maleate (Fenistil) in children’s practice, including the use for the relief of skin itching of various genesis.

Combined therapy for treatment of acute respiratory viral infections: analysis of combined complex AnviMax

2020 ◽  
pp. 33-48
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin
Keyword(s):  
Viral Infections ◽  
Respiratory Infections ◽  
Combined Therapy ◽  
Allergic Inflammation ◽  
Histamine Receptor ◽  
Receptor Blockers ◽  
Respiratory Viral Infections ◽  
Comprehensive Programs ◽  
Viral Respiratory Infections ◽  
Viral Respiratory

The annual increase in the incidence of influenza, SARS, and the COVID‑19 pandemic indicate the need for comprehensive programs to support congenital antiviral immunity. To increase the effectiveness of the treatment of viral respiratory infections, it is important to attenuate the effects of the so-called cytokine storm and enhanced compensation of the patient’s comorbid pathologies. Increasing the availability of zinc, vitamin C and rutoside can improve the body’s resistance to viral infections. In addition to micronutrients, to reduce the activity of allergic inflammation, second-generation H1-histamine receptor blockers (loratadine, etc.) and calcium gluconate can be used. To lower the  temperature, it is important to include paracetamol in therapy.

scholarly journals The effect of sleep disorders on health and the possibility of correction of sleep disorders

2018 ◽  
pp. 30-33 ◽  
Author(s):  
S. L. Tsenteradze ◽  
M. G. Poluektov
Keyword(s):  
Sleep Disorders ◽  
Gaba Receptors ◽  
Negative Impact ◽  
Histamine Receptor ◽  
Behavioural Therapy ◽  
Medicinal Products ◽  
Immunodeficiency Disorder ◽  
Cognitive Behavioural ◽  
Significant Negative Impact ◽  
Receptor Blockers

Treatment of insomnia is an important medical and social problem due to its widespread prevalence and significant negative impact on human health. The state of chronic cerebral hyper-activation, which has cognitive, electrophysiological and metabolic manifestations, plays an important role in the development of insomnia. The sleep disorder has been proven to be a risk factor for the development of arterial hypertension, metabolic syndrome, immunodeficiency disorder and cognitive impairment. Nonmedicinal and medicinal products are used to treat insomnia. Cognitive-behavioural therapy may be effective as a psychotherapy.  Non-benzodiazepine GABA-receptors agonists are most often used to treat chronic insomnia and histamine receptor blockers to treat acute insomnia among the other drugs of this group.

More Blockbuster Drugs for Ulcers: Prilosec, Nexium, and Other Proton-Pump Inhibitors

2014 ◽  
Author(s):  
Jie Jack Li
Keyword(s):  
Gastric Acid ◽  
Histamine Receptor ◽  
The United States ◽  
Gastric Fistula ◽  
Sphincter Muscle ◽  
Physiological Control ◽  
Army Officer ◽  
Stomach Acid ◽  
Receptor Blockers ◽  
The 19Th Century

In the first half of the 19th century, British physician William Prout conclusively showed that gastric juice contains hydrochloric acid. U.S. Army officer William Beaumont examined the physiological control mechanism of gastric acid secretion by studying Alexis St. Martin’s chronic gastric fistula that had resulted from a gunshot wound in the 1820s. Gastric acid is essential to digest protein and emulsify fats. It breaks down food so it can go on to the small intestine where nutrients are absorbed. Low levels of gastric acid can contribute to a myriad of discomforts and diseases. On the other hand, too much of a good thing is bad. High levels of gastric acid often result in heartburn and ulcers. Heartburn is a symptom produced by reflux when digesting food and gastric acid passes back up into the esophagus through the sphincter muscle at the top of the stomach. It is also known as GERD, for gastroesophageal reflux disease. If reflux occurs often and the body fails to sufficiently clear the acidic mixture back into the stomach, the tissue of the esophagus can be damaged, and that is when ulcers develop. Forty million Americans experience heartburn two days a week, and 60 million have it at least once a month. The disorder costs an estimated $10 billion in the United States, counting visits to doctors and hospitals, medications, and time lost from work, according to the American Gastroenterology Association. Before the emergence of Tagamet and Zantac as H2 histamine-receptor blockers for the treatment of heartburn and ulcers, numerous medicines were available, but none were satisfactory. For over a century, heartburn sufferers had been taking over-the-counter (OTC) antacid products such as Alka-Seltzer, Maalox, Mylanta, Pepto-Bismol, Rolaids, and Tums. Most of them contain simple inorganic bases as the principal active ingredients. Americans alone spend approximately $1 billion a year on these antacids, which bring relief within minutes and work by neutralizing the stomach acid that causes heartburn.

Histamine, histamine receptors, and anti-histamines in the context of allergic responses

2019 ◽  
Vol 6 (2) ◽  
pp. 35-51
Author(s):  
Amarilla Mandola ◽  
Asako Nozawa ◽  
Thomas Eiwegger
Keyword(s):  
Immune Cells ◽  
Histamine Receptor ◽  
Clinical Applications ◽  
Histamine Receptors ◽  
Allergic Response ◽  
Atopic Diseases ◽  
Clinical Routine ◽  
Receptor Blockers ◽  
Guidelines And Recommendations ◽  
G Protein Coupled

Histamine is a bioactive amine which is considered a key player in the allergic response. Thus, histamine receptor blockers (antihistamines) play an important role in the treatment of a number atopic diseases such as allergic rhinitis, conjunctivitis, and acute and chronic forms of urticaria. Histamine is produced by immune cells but also by bacteria in the gut. Beyond its role in the acute allergic response, histamine exerts numerous effects by binding to its 4 pleiotropic G-protein coupled histamine receptors. Here, we describe the roles of these histamine receptors and antihistamines in the human system, clinical applications, side effects, and novel concepts for the usage of antihistamines with different specificity based on guidelines and recommendations. Statement of novelty: This review provides an overview of histamine receptors and links it to clinical relevance of antagonizing their action in clinical routine.

scholarly journals Prophylactic Administration of Histamine 1 and/or Histamine 2 Receptor Blockers in the Prevention of Heparin- and Protamine-Related Haemodynamic Effects

1996 ◽  
Vol 24 (5) ◽  
pp. 559-563 ◽  
Author(s):  
M. Kanbak ◽  
S. Kahraman ◽  
B. Celebioglu ◽  
N. Akpolat ◽  
S. Ercan ◽  
...  
Keyword(s):  
Histamine Receptor ◽  
Haemodynamic Effects ◽  
Control Group ◽  
Plasma Histamine ◽  
Central Venous ◽  
Prophylactic Administration ◽  
H2 Receptor Blockers ◽  
Heparin Plasma ◽  
Receptor Blockers ◽  
The Right

The efficacy of prophylactic administration of H1 and H2 receptor blockers to prevent adverse haemodynamic responses to heparin and protamine was studied. The control group (n=10) received no histamine receptor blocker, group H1 (n=10) received oral terfenadine 60 mg, group H2 (n=10) received oral ranitidine 300 mg, and group H1+H2 (n=10) received both terfenadine and ranitidine on the night before the operation and on call to the operating room. Heparin sulphate 300 U/kg was injected directly into the right atrium, and protamine hydrochloride was administered at the conclusion of bypass over at least three minutes through a peripheral route. Following the injection of heparin, plasma histamine-like activity (H-LA) was increased significantly in all four groups. While systolic, diastolic, mean arterial and central venous pressures were decreased significantly in the control group, no significant changes were observed in the H1 and H2 groups. Protamine infusion did not lead to an increase in H-LA. Prophylactic administration of histamine receptor blockers (H1 or H2) attenuated the heparin-induced adverse haemodynamic response but did not change the protamine-related haemodynamic effects. Factors other than histamine may play a major role in protamine induced cardiovascular changes.

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