Direct seeded rice is an emerging production technology in India due to less requirement of water, labour and capital input initially. But direct seeded rice face severe infestation of weeds. A field experiment was conducted during the kharif 2012 at Students’ Farm of College of Agriculture, CCS Haryana Agricultural University; Kaul campus (Kaithal) to study the performance of sequential application of herbicides on weed flora in direct seeded rice. The herbicidal treatments included two pre emergence herbicides i.e. pendimethalin 1000 g/ha and oxadiargyl 100 g/ ha and four post emergence herbicides (bispyribac sodium 25 g/ha, fenoxaprop 67 g/ha, ethoxysulfuron 18.75 g/ha and metsulfuron methyl 10% + chlorimuron ethyl 10% WP ready mix (Almix) 4 g/ha). Weed free and weedy check were also included. The results showed that grasses were the dominant weed flora (49 %) followed by sedges (34%) and broad leaf weeds (17%).Sequential application of pendimethalin 1000 g/ha fb bispyribac sodium 25 g/ha and metsulfuron methyl + chlorimuron ethyl RM (Almix) 4 g/ha gave significantly lower weed density (p=0.05) and higher weed control efficiency which resulted in more number of effective tillers (209.3), filled grains/panicle (83.7) and grain yield (3.97 t/ha).