scholarly journals Effects of a single session of cathodal transcranial direct current stimulation primed intermittent theta-burst stimulation on heart rate variability and cortical excitability measures

2021 ◽  
Vol 65 ◽  
pp. 162-166
Author(s):  
B. N. Keerthy ◽  
Sai Sreevalli Sarma Sreepada ◽  
Shalini S. Naik ◽  
Anushree Bose ◽  
Raju Hanumegowda ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Dorsolateral Prefrontal Cortex ◽  
Cortical Excitability ◽  
Single Session ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Cathodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
Before And After ◽  
Theta Burst

Objectives: Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been used as neuromodulators in neuropsychiatric conditions. This study is aimed to find the effects of a single session of priming cathodal tDCS with intermittent theta-burst stimulation (iTBS) over left dorsolateral prefrontal cortex on heart rate variability (HRV) and cortical excitability parameters before and after perturbation. Materials and Methods: The neuromodulatory techniques used in the study were Cathodal tDCS for 20 min followed by iTBS for 3 min on the left dorsolateral prefrontal cortex (DLPFC). HRV variables and TMS parameters were recorded before and after this intervention of combined neuromodulation in 31 healthy volunteers (20 males and 11 females; age range of 19–35 years with Mean ± SD = 24.2 ± 4.7 years). Results: The results showed an overall increase in cortical excitability and parasympathetic dominance in healthy volunteers. Other measures of cortical excitability and HRV did not change significantly following single session of combined neuromodulation. Conclusion: This study showed that there is an overall increase in cortical excitability and parasympathetic dominance in the cohort of healthy volunteers following a combination of neuromodulation involving cathodal tDCS followed by iTBS over left DLPFC. Future studies exploring the effects of other possible combinations with sham stimulation could be carried out to explore the utility of dual stimulation as add-on therapy in disorders.

scholarly journals Intermittent Theta-Burst Stimulation Over the DorsoLateral PreFrontal Cortex (DLPFC) in Healthy Subjects Produces No Cumulative Effect on Cortical Excitability

2021 ◽  
Vol 12 ◽  
Author(s):  
Noomane Bouaziz ◽  
Charles Laidi ◽  
Fanny Thomas ◽  
Palmyre Schenin-King Andrianisaina ◽  
Virginie Moulier ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Cortical Excitability ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Controlled Trial ◽  
Ease Of Use ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Dorsolateral Prefrontal ◽  
Theta Burst

Background: Intermittent Theta Burst Stimulation (iTBS) is a design of repetitive Transcranial Magnetic Stimulation (rTMS) and could be a candidate to replace rTMS in the treatment of depression, thanks to its efficacy, shorter duration, and ease of use. The antidepressant mechanism of iTBS, and whether this mechanism is mediated by a modulation of cortical excitability, remains unknown.Methods: Using a randomized double-blind, sham-controlled trial, 30 healthy volunteers received either iTBS or a sham treatment targeting the left DorsoLateral PreFrontal Cortex (L-DLPFC), twice a day over 5 consecutive days. Cortical excitability was measured before and after the 5 days of stimulation.Results: No difference in cortical excitability was observed between active or sham iTBS.Conclusion: Our study does not support any effect on cortical excitability of repetitive iTBS targeting the L-DLPFC.

scholarly journals Plasticity Induced by Intermittent Theta Burst Stimulation in Bilateral Motor Cortices Is Not Altered in Older Adults

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Daina S. E. Dickins ◽  
Martin V. Sale ◽  
Marc R. Kamke
Keyword(s):  
Older Adults ◽  
Cortical Excitability ◽  
Motor Evoked Potentials ◽  
Single Pulse ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Motor Tasks ◽  
Age Related ◽  
Before And After ◽  
Theta Burst

Numerous studies have reported that plasticity induced in the motor cortex by transcranial magnetic stimulation (TMS) is attenuated in older adults. Those investigations, however, have focused solely on the stimulated hemisphere. Compared to young adults, older adults exhibit more widespread activity across bilateral motor cortices during the performance of unilateral motor tasks, suggesting that the manifestation of plasticity might also be altered. To address this question, twenty young (<35 years old) and older adults (>65 years) underwent intermittent theta burst stimulation (iTBS) whilst attending to the hand targeted by the plasticity-inducing procedure. The amplitude of motor evoked potentials (MEPs) elicited by single pulse TMS was used to quantify cortical excitability before and after iTBS. Individual responses to iTBS were highly variable, with half the participants showing an unexpected decrease in cortical excitability. Contrary to predictions, however, there were no age-related differences in the magnitude or manifestation of plasticity across bilateral motor cortices. The findings suggest that advancing age does not influence the capacity for, or manifestation of, plasticity induced by iTBS.

scholarly journals Theta burst stimulation of dorsolateral prefrontal cortex modulates pathological language switching: A case report

2011 ◽  
Vol 487 (3) ◽  
pp. 378-382 ◽  
Author(s):  
Raffaele Nardone ◽  
Pierpaolo De Blasi ◽  
Jürgen Bergmann ◽  
Francesca Caleri ◽  
Frediano Tezzon ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Case Report ◽  
Dorsolateral Prefrontal Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Language Switching ◽  
Dorsolateral Prefrontal ◽  
Theta Burst ◽  
Stimulation Of
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