scholarly journals A case of multiple synchronously diagnosed brain metastases from alveolar soft part sarcoma without concurrent lung involvement

2021 ◽  
Vol 12 ◽  
pp. 111
Author(s):  
Mark A. Damante ◽  
Kristin M. Huntoon ◽  
Joshua D. Palmer ◽  
David A. Liebner ◽  
James Bradley Elder
Keyword(s):  
Soft Tissue ◽  
Brain Metastasis ◽  
Lung Metastasis ◽  
Soft Tissue Mass ◽  
Soft Part ◽  
Primary Lesion ◽  
Alveolar Soft Part Sarcoma ◽  
Lung Involvement ◽  
Tissue Mass ◽  
Intracranial Involvement

Background: Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a propensity for early hematogenous dissemination to the lungs and frequent brain metastasis. The development of lung metastasis almost invariably precedes intracranial involvement. There are no previously reported cases in which a patient was synchronously diagnosed with ASPS and multiple brain metastasis without lung involvement. Case Description: A 29-year-old gentleman was found to have three intracranial lesions following the onset of generalized seizures. Staging studies identified a soft-tissue mass in the left thigh and an adjacent femoral lesion. Biopsy of the soft-tissue mass was consistent with ASPS. The patient then underwent neoadjuvant stereotactic radiotherapy to all three brain lesions, followed by en bloc resection of the dominant lesion. The patient was then started on a programmed death-ligand 1 (PD-L1) inhibitor. Subsequent surgical resection of the primary lesion and femur metastasis demonstrates a histopathologic complete response of the bony metastasis and partial response of the primary lesion. At present, the patient has received 14 cycles of atezolizumab without recurrence of the primary or bony lesions and the irradiated intracranial disease has remained stable without recurrence of the resected dominant lesion. Conclusion: While intracranial involvement is relatively common in ASPS, a case with multiple, synchronously diagnosed brain metastasis without concurrent lung metastasis has not been described. The presented case discusses the safety and efficacy of aggressive management of intracranial disease in the setting of atezolizumab. Prospective evaluation of the efficacy of checkpoint inhibitors and the prognostic value of PD-L1 expression in ASPS with brain metastasis are necessary.

scholarly journals Lung Metastasis of Primary Alveolar Soft-Part Sarcoma Occurring 20 Years after Initial Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
R. F. Falkenstern-Ge ◽  
M. Kimmich ◽  
M. Wohlleber ◽  
A. Grabner ◽  
G. Friedel ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Lung Metastasis ◽  
Lung Tumor ◽  
Lung Metastases ◽  
Soft Part ◽  
Lower Limbs ◽  
Alveolar Soft Part Sarcoma ◽  
Malignant Soft Tissue Tumor ◽  
Previously Treated ◽  
The Right

A 30-year old woman was referred to our center because of suspicion of a primary lung tumor of the right upper lobe. Histological examination of the lung lesion revealed lung metastasis of a previously treated alveolar soft part sarcoma of the musculus vastus medialis of the right femur, which was resected 20 years ago. Alveolar soft-part sarcoma is a rare malignant tumor that occurs most often in the soft tissue of lower limbs. It is a slow-growing malignant soft tissue tumor arising in muscle tissue, usually in young adults. Due to pleural and extensive mediastinal infiltration with bilateral lung metastases, a systemic treatment with chemotherapy doxorubicin and ifosfamide was initiated. Late metastases from previously treated alveolar part sarcoma should be considered in patients with suspicious lung lesions even if surgical treatment was performed a long time ago.

scholarly journals Alveolar soft part sarcoma causing perianal abscess

2011 ◽  
Vol 93 (5) ◽  
pp. e35-e36 ◽  
Author(s):  
Niall Sullivan ◽  
Tom McCulloch ◽  
David Leverton
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Lung Metastases ◽  
Soft Part ◽  
Perianal Abscess ◽  
Alveolar Soft Part Sarcoma ◽  
Fistula Tract ◽  
Tissue Mass ◽  
Cellular Origin ◽  
One Year

A 34-year-old woman presented with a perianal abscess that communicated with the vagina. There was a background of a one-year history of a conservatively treated, traumatic, paravaginal haematoma. Histology of the fistula tract showed alveolar soft part sarcoma and subsequent imaging identified a large soft tissue mass in the pelvis with lung metastases. Alveolar soft part sarcoma is a rare soft tissue sarcoma of unknown cellular origin affecting predominantly young women, often in deep soft tissues and lower extremities.

Microsurgical Management of Early Onset Alveolar Soft Part Sarcoma of the Oral Tongue: Case Report and Review of the Literature

2021 ◽  
pp. 000348942110212
Author(s):  
Jacob C. Lucas ◽  
Omar A. Karadaghy ◽  
Brian Andrews ◽  
Elizabeth Friedman ◽  
Kiran Kakarala ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Part ◽  
Soft Tissue Sarcomas ◽  
Alveolar Soft Part Sarcoma ◽  
Microvascular Reconstruction ◽  
Retrospective Case ◽  
Tissue Mass ◽  
Radial Forearm ◽  
Posterior Tongue

Objectives: Alveolar soft part sarcoma is a rare subset of soft tissue sarcomas, typically presenting in subjects 15 to 35 years of age. Usual presentation sites are the trunk, extremities, and the head and neck. Subjects younger than 5 years are rarely affected. Methods: In this retrospective case report, we present a 16-month old male with a rapidly growing soft tissue mass of the anterior and posterior tongue, found to be alveolar soft part sarcoma. Results: The subject was treated with primary surgical resection and the resulting defect was reconstructed with a radial forearm free flap. Conclusions: To our knowledge, this is the youngest subject to have been diagnosed with alveolar soft part sarcoma. Surgical extirpation and microvascular reconstruction were successful, and the patient remains disease free 4 years post-operatively.

scholarly journals Alveolar Soft Part Sarcoma of Hypopharynx; A Case Report

2020 ◽  
pp. 014556132098216
Author(s):  
Abdulla Al Nakshabandi ◽  
Aqil M. Daher
Keyword(s):  
Soft Tissue ◽  
Soft Part ◽  
Incidental Finding ◽  
Smooth Muscle Actin ◽  
Alveolar Soft Part Sarcoma ◽  
Tissue Mass ◽  
Left Wall ◽  
First Case ◽  
Rare Cells

Alveolar soft part sarcoma (ASPS) is an aggressive soft-tissue malignancy, notorious for its metastasis to other tissues. A considerable number of cases in the head and neck have been reported but not in the hypopharynx. We describe a 31-year-old man with an incidental finding of a hypopharyngeal mass. Flexible laryngoscopy revealed a fleshy mass 2 × 2 cm2 originating from the left hypopharynx and overlying the epiglottis. Computed tomography scan demonstrated a soft tissue mass in the left wall of the oropharynx measuring about 2.2 × 1.8 cm2, projecting into the hypopharyngeal air space. Magnetic resonance imaging showed a significant thickening of the left hypopharyngeal wall forming a mass lesion occupying the left pyriform sinus and abutting the left aryepiglottic fold. Histopathology indicated that tumor cells were polygonal and epithelioid, with abundant eosinophilic to clear flocculent cytoplasm, eccentric nuclei, and prominent nucleoli. The tumor was positive for smooth muscle actin with rare cells staining for Human Melanoma Black (HMB45). Fluorescence in situ hybridization for transcription factor E3 was also performed and supported the above diagnosis. Our study reports the first case of ASPS in the hypopharynx.

Soft tissue mass of the thigh: presentation

2007 ◽  
Vol 36 (12) ◽  
pp. 1177-1177 ◽  
Author(s):  
Tomoya Sakabe ◽  
Hiroaki Murata ◽  
Yukiko Tokumoto ◽  
Kazutaka Koto ◽  
Takaaki Matsui ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Tissue Mass

DIAGNOSIS OF IMPAIRED FETAL GROWTH IN NEWBORN INFANTS

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 511-522 ◽  
Author(s):  
Herbert C. Miller ◽  
Khatab Hassanein
Keyword(s):  
Birth Weight ◽  
Soft Tissue ◽  
Body Length ◽  
Fetal Growth ◽  
Head Circumference ◽  
Soft Tissue Mass ◽  
Newborn Infants ◽  
Tissue Mass ◽  
Growth Impairment ◽  
Short Body

Measurements of crown-heel length, head circumference, and birth weight were made on a large number of newborn infants. Birth weight by itself was frequently not a valid measure of fetal growth impairment. By including measurements of body length and head size along with birth weight, four distinct patterns of fetal growth impairment were identified. The four patterns included infants who had abnormally short body lengths for dates, infants who had evidence of disproportionate growth between body length and head circumference, infants who accumulated excessive amounts of soft-tissue mass, and infants who accumulated too little soft-tissue mass. Criteria for diagnosing each pattern were obtained prospectively and have been presented with allowances made for the effects of race, sex, fetal age, and parity on each pattern. The separate identification of the four patterns provided a more precise description of fetal growth impairment than could be obtained from birth weight and calculated gestational age.

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