scholarly journals Chemical Biology Tools to Study Lipids and their Metabolism with Increased Spatial and Temporal Resolution

2021 ◽  
Vol 75 (12) ◽  
pp. 1012-1016
Author(s):  
Clémence Simon ◽  
Suihan Feng ◽  
Howard Riezman
Keyword(s):  
Lipid Metabolism ◽  
Temporal Resolution ◽  
Chemical Biology ◽  
Challenging Problem ◽  
Complex Lipid ◽  
Lipid Organization ◽  
Genetic Techniques ◽  
Chemical Tools ◽  
Cellular Components ◽  
Subcellular Level

Lipids are important cellular components providing many essential functions. To fulfill these various functions evolution has selected for a diverse set of lipids and this diversity is seen at the organismal, cellular and subcellular level. Understanding how cells maintain this complex lipid organization is a very challenging problem, which for lipids, is not easily addressed using biochemical and genetic techniques. Therefore, chemical tools have an important role to play in our quest to understand the complexities of lipid metabolism. Here we discuss new chemical tools to study lipids, their distribution and metabolism with increased spatial and temporal resolution.

Inherited Disorders of Complex Lipid Metabolism: A Clinical Review

2021 ◽  
Author(s):  
Changrui Xiao ◽  
Francis Rossignol ◽  
Frédéric M. Vaz ◽  
Carlos R. Ferreira
Keyword(s):  
Lipid Metabolism ◽  
Clinical Review ◽  
Inherited Disorders ◽  
Complex Lipid

The chemical biology of branched-chain lipid metabolism

2003 ◽  
Vol 42 (5) ◽  
pp. 359-376 ◽  
Author(s):  
Mridul Mukherji ◽  
Christopher J. Schofield ◽  
Anthony S. Wierzbicki ◽  
Gerbert A. Jansen ◽  
Ronald J.A. Wanders ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Chemical Biology ◽  
Branched Chain

Niemann–Pick type C fibroblasts have a distinct microRNA profile related to lipid metabolism and certain cellular components

2010 ◽  
Vol 403 (3-4) ◽  
pp. 316-321 ◽  
Author(s):  
Bilge Ozsait ◽  
Evrim Komurcu-Bayrak ◽  
Mari Levula ◽  
Nihan Erginel-Unaltuna ◽  
Mika Kähönen ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Microrna Profile ◽  
Type C ◽  
Niemann Pick ◽  
Cellular Components

scholarly journals Dynamic Interactions between Autophagosomes and Lipid Droplets in Chlamydomonas reinhardtii

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 992 ◽  
Author(s):  
Quynh-Giao Tran ◽  
Hyang Ran Yoon ◽  
Kichul Cho ◽  
Seon-Jin Lee ◽  
José L. Crespo ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Chlamydomonas Reinhardtii ◽  
Lipid Droplets ◽  
Fluorescent Protein ◽  
Early Stage ◽  
Dynamic Interactions ◽  
Transmission Electron ◽  
Cellular Components ◽  
Related Pathway ◽  
Shed Light

Autophagy is a highly conserved catabolic process in eukaryotic cells by which waste cellular components are recycled to maintain growth in both favorable and stress conditions. Autophagy has been linked to lipid metabolism in microalgae; however, the mechanism underlying this interaction remains unclear. In this study, transgenic Chlamydomonas reinhardtii cells that stably express the red fluorescent protein (mCherry) tagged-ATG8 as an autophagy marker were established. By using this tool, we were able to follow the autophagy process in live microalgal cells under various conditions. Live-cell and transmission electron microscopy (TEM) imaging revealed physical contacts between lipid droplets and autophagic structures during the early stage of nitrogen starvation, while fusion of these two organelles was observed in prolonged nutritional deficiency, suggesting that an autophagy-related pathway might be involved in lipid droplet turnover in this alga. Our results thus shed light on the interplay between autophagy and lipid metabolism in C. reinhardtii, and this autophagy marker would be a valuable asset for further investigations on autophagic processes in microalgae.

Enzymes of Complex Lipid Metabolism

1973 ◽  
Vol 42 (1) ◽  
pp. 61-90 ◽  
Author(s):  
S Gatt ◽  
Y Barenholz
Keyword(s):  
Lipid Metabolism ◽  
Complex Lipid

scholarly journals Podocyte Lipotoxicity in CKD

Kidney360 ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 755-762
Author(s):  
Jin-Ju Kim ◽  
Sydney S. Wilbon ◽  
Alessia Fornoni
Keyword(s):  
Lipid Metabolism ◽  
Lipid Accumulation ◽  
Kidney Diseases ◽  
Treatment Options ◽  
The United States ◽  
Differentiated Cells ◽  
Filtration Barrier ◽  
And Function ◽  
Cellular Components ◽  
Novel Therapeutic

CKD represents the ninth most common cause of death in the United States but, despite this large health burden, treatment options for affected patients remain limited. To remedy this, several relevant pathways have been identified that may lead to novel therapeutic options. Among them, altered renal lipid metabolism, first described in 1982, has been recognized as a common pathway in clinical and experimental CKD of both metabolic and nonmetabolic origin. This observation has led many researchers to investigate the cause of this renal parenchyma lipid accumulation and its downstream effect on renal structure and function. Among key cellular components of the kidney parenchyma, podocytes are terminally differentiated cells that cannot be easily replaced when lost. Clinical and experimental evidence supports a role of reduced podocyte number in the progression of CKD. Given the importance of the podocytes in the maintenance of the glomerular filtration barrier and the accumulation of TG and cholesterol-rich lipid droplets in the podocyte and glomerulus in kidney diseases that cause CKD, understanding the upstream cause and downstream consequences of lipid accumulation in podocytes may lead to novel therapeutic opportunities. In this review, we hope to consolidate our understanding of the causes and consequences of dysregulated renal lipid metabolism in CKD development and progression, with a major focus on podocytes.

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