In recent years, Trimaran platform design has got the attention of naval architects owing to its superior seagoing performance. Trimaran structure experiences severe loads due to its unique configuration and high speed, causing stress concentration, especially in cross deck region and accelerate fatigue damage. This paper presents fatigue strength assessment of Trimaran structure by simplified procedure. A methodology is proposed to evaluate fatigue loads and loading conditions by load combinations of direct calculation procedure of Lloyds Register Rules for Classification of Trimaran (LR Rules). Global FE analysis, in ANSYS, is performed to investigate the stress response. The stress range is computed by hot-spot stress approach, and its long term distribution is specified by Weibull distribution. Fatigue damage of selected critical details is calculated using mathematical formulation of simplified fatigue assessment procedure of Common Structure Rules (CSR).