PLATELETS COUNT IN EARLY POSTOPERATIVE PERIOD IN YOUNG CHILDREN UNDERWENT CONGENITAL HEART DISEASES SURGERY

Author(s):  
Л.З. Бикташева ◽  
В.А. Мазурок ◽  
И.Н. Меньшугин ◽  
А.Е. Баутин ◽  
О.В. Сироткина

Цель исследования: выявить причины развития и определить влияние тромбоцитопении на течение послеоперационного периода у детей после хирургической коррекции врожденных пороков сердца в условиях искусственного кровообращения. Материалы и методы. Проведено сравнение течения раннего послеоперационного периода у детей с применением торакальной эпидуральной (ТЭА) анестезии (n = 68) и высокоопиоидной (ВВА) внутривенной анестезии (n = 84). Взаимосвязь между видом анестезии и результатами хирургического вмешательства оценивали по клинико-лабораторным характеристикам, в том числе по количеству тромбоцитов на 1, 2, 3 сутки и при выписке из стационара. Тромбоцитопенией считали количество тромбоцитов менее 150×109/л. Результаты. При использовании ТЭА уровень интраоперационной гликемии был ниже, а тромбоцитопения на 2 и 3 сутки после операции развивалась реже, чем при ВВА. При ишемии миокарда (ИМ) более 60 минут частота тромбоцитопении на 1 и 3 сутки после операции была выше, чем при ИМ менее 60 минут. Послеоперационная тромбоцитопения коррелировала с развитием дыхательной недостаточности и продленной ИВЛ. Количество тромбоцитов было достоверно ниже на 1 и 3 сутки после операций с выраженной интраоперационной сердечной недостаточностью. Заключение. Ранняя послеоперационная тромбоцитопения коррелирует с периоперационными осложнениями. Использование ТЭА коррелирует с меньшей выраженностью интраоперационной гипергликемии и ранним восстановлением количества тромбоцитов. The aim of study was to identify the reasons of thrombocytopenia development and to determine its effect on postoperative period in children after surgical correction of congenital heart diseases under cardiopulmonary bypass. Materials and methods. We compared 2 groups of children after surgery with thoracic epidural (TEA) anesthesia (n = 68) and high-opioid intravenous (HIA) anesthesia (n = 84) and assessed the relationship between the type of anesthesia and surgery results by clinical and laboratory characteristics, including the number of platelets on 1, 2, 3 days of postoperative period and at discharge from the hospital. Thrombocytopenia was the number of platelets less than 150×109/l. Results. With TEA usage the level of intraoperative glycemia was lower, and thrombocytopenia on 2 and 3 days after surgery developed less frequently than with HIA. Thrombocytopenia occurrence on days 1 and 3 after surgery was higher after myocardial ischemia (MI) for more than 60 minutes than with MI less than 60 minutes. Postoperative thrombocytopenia correlated with the development of respiratory failure and prolonged artificial lung ventilation. Platelets number was significantly lower on 1 and 3 days after operations with severe intraoperative heart failure. Conclusion. Early postoperative thrombocytopenia correlates with perioperative complications. TEA usage correlates with lesser severity of intraoperative hyperglycemia and early recovery of platelets count.

Author(s):  
Hui Shi ◽  
Shiwei Yang ◽  
Ning Lin ◽  
Peng Huang ◽  
Rongbin Yu ◽  
...  

AbstractThe aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal children as control group were recruited. Their pregnant histories were interviewed by questionnaire and the MTHFR rsl801133 and rsl801131 were genotyped. The case–control analysis was used to find out the relationship between maternal SNPs of MTHFR gene and offspring CHDs. And the plasma HCY concentration of the mothers of CHDs children was detected. This case–case study was intended to find out the relevance between maternal HCY level and SNPs of MTHFR gene. There were significant differences in the gender of children, occupation of mothers, family history with CHDs, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure in CHDs group and control group (P < 0.05). MTHFR rs1801133 was significantly associated with their offspring CHDs in mothers. The polymorphism of maternal MTHFR rs1801133 increased plasma HCY level, especially the homozygous mutation. Besides the environmental factors, our results suggested that the maternal MTHFR rs1801133 polymorphism might be a risk factor of their offspring CHDs, which may be due to the hyperhomocysteinemia by abnormal metabolism of HCY.


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