Effect of age and gender on the pharmacokinetics of the oral and IV omadacycline, a new class of aminomethylcyclines

2016 ◽  
Author(s):  
Stephen Villano
Keyword(s):  
Age And Gender ◽  
New Class ◽  
And Gender ◽  
Effect Of Age

scholarly journals Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia: A Proof-of-Concept Study

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 461
Author(s):  
Weslania Nascimento ◽  
Noemí Tomsen ◽  
Saray Acedo ◽  
Cristina Campos-Alcantara ◽  
Christopher Cabib ◽  
...  
Keyword(s):  
Oropharyngeal Dysphagia ◽  
Sensory Stimulation ◽  
Age And Gender ◽  
Post Stroke ◽  
Brainstem Reflex ◽  
Trpv1 Receptors ◽  
Volume Viscosity ◽  
And Gender ◽  
Effect Of Age ◽  
Stimulation Of

Spontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG). We studied the effect of age and gender on spontaneous swallowing frequency (SSF) in healthy volunteers and assessed basal SSF and TRPV1 stimulation effect on SSF in patients with post-stroke oropharyngeal dysphagia (OD). The effect of age and gender on SSF was examined on 141 healthy adult volunteers (HV) divided into three groups: GI—18–39 yr, GII—40–59 yr, and GIII—>60 yr. OD was assessed by the Volume–Viscosity Swallowing Test (VVST). The effect of sensory stimulation with capsaicin 10−5 M (TRPV1 agonist) was evaluated in 17 patients with post-stroke OD, using the SSF. SSF was recorded in all participants during 10 min using surface electromyography (sEMG) of the suprahyoid muscles and an omnidirectional accelerometer placed over the cricothyroid cartilage. SSF was significantly reduced in GII (0.73 ± 0.50 swallows/min; p = 0.0385) and GIII (0.50 ± 0.31 swallows/min; p < 0.0001) compared to GI (1.03 ± 0.62 swallows/min), and there was a moderate significant correlation between age and SFF (r = −0.3810; p < 0.0001). No effect of gender on SSF was observed. Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 ± 0.32 swallows/min vs post-capsaicin: 0.81 ± 0.51 swallow/min; p = 0.0003). OD in patients with post-stroke OD and acute stimulation with TRPV1 agonists caused a significant increase in SSF, further suggesting the potential role of pharmacological stimulation of sensory pathways as a therapeutic strategy for CPG activation in patients with OD.

scholarly journals A Cross-National Comparison Of The Effect Of Age And Gender On Health-Related Quality Of Life (Hrql)

2016 ◽  
Vol 19 (7) ◽  
pp. A471 ◽  
Author(s):  
R Rendas-Baum ◽  
MK White ◽  
M Kosinski ◽  
J Vietri ◽  
JB Bjorner
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Age And Gender ◽  
Related Quality ◽  
National Comparison ◽  
Health Related ◽  
And Gender ◽  
Effect Of Age ◽  
Cross National

The effect of age and gender on arterial stiffness in healthy Caucasian Canadians

2008 ◽  
Vol 17 (17) ◽  
pp. 2311-2317 ◽  
Author(s):  
Joseph P Noon ◽  
Timothy C Trischuk ◽  
Sylvia A Gaucher ◽  
Sean Galante ◽  
Roger L Scott
Keyword(s):  
Arterial Stiffness ◽  
Age And Gender ◽  
And Gender ◽  
Effect Of Age

Tear film evaporation—Effect of age and gender

2010 ◽  
Vol 33 (4) ◽  
pp. 171-175 ◽  
Author(s):  
Michel Guillon ◽  
Cécile Maïssa
Keyword(s):  
Tear Film ◽  
Age And Gender ◽  
Film Evaporation ◽  
And Gender ◽  
Effect Of Age

EFFECT OF AGE AND GENDER ON FASTING AND FOOD-STIMULATED LEVELS OF CALCITONIN, PARATHYROID, AND GASTRIN HORMONES IN HEALTHY ADULTS

2019 ◽  
Vol 25 (6) ◽  
pp. 526-533
Author(s):  
Munther S. Momani ◽  
Ayman A. Zayed ◽  
Hussam H. Alhawari ◽  
Enas Abu Salim ◽  
Ahmad M. Ghazali ◽  
...  
Keyword(s):  
Healthy Adults ◽  
Age And Gender ◽  
And Gender ◽  
Effect Of Age
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