SURGICAL COMPLEXITY, COMPLICATIONS AND SURVIVAL AFTER ADOPTING A STRATEGY OF PRIMARY AND COMPLETE CYTOREDUCTION IN OVARIAN CANCER: EXPERIENCE FROM A REFERRAL CENTER IN EASTERN INDIA

2016 ◽  
Author(s):  
Asima Mukhopadhyay
Keyword(s):  
Ovarian Cancer ◽  
Complete Cytoreduction ◽  
Eastern India ◽  
Referral Center ◽  
Surgical Complexity ◽  
Cancer Experience

scholarly journals Evolution of surgical complexity in ovarian cancer: Experience from a developing tertiary referral center in Eastern India

2016 ◽  
Vol 141 ◽  
pp. 188-189
Author(s):  
A. Mukhopadhyay ◽  
D. Thangjam ◽  
P.G. Lucksom ◽  
B. Chakraborti ◽  
A. Ghosh ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Eastern India ◽  
Tertiary Referral ◽  
Tertiary Referral Center ◽  
Referral Center ◽  
Surgical Complexity ◽  
Cancer Experience

scholarly journals The Uncertain Benefit of Adjuvant Chemotherapy in Advanced Low-Grade Serous Ovarian Cancer and the Pivotal Role of Surgical Cytoreduction

2021 ◽  
Vol 10 (24) ◽  
pp. 5927
Author(s):  
Racheal Louise Johnson ◽  
Alexandros Laios ◽  
David Jackson ◽  
David Nugent ◽  
Nicolas Michel Orsi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Adjuvant Chemotherapy ◽  
Progression Free Survival ◽  
Primary Treatment ◽  
Complete Cytoreduction ◽  
Low Grade ◽  
Serous Ovarian Cancer ◽  
Prognostic Features ◽  
Significant Survival ◽  
Surgical Complexity

In our center, adjuvant chemotherapy is routinely offered in high-grade serous ovarian cancer (HGSOC) patients but less commonly as a standard treatment in low-grade serous ovarian cancer (LGSOC) patients. This study evaluates the efficacy of this paradigm by analysing survival outcomes and by comparing the influence of different clinical and surgical characteristics between women with advanced LGSOC (n = 37) and advanced HGSOC (n = 300). Multivariate analysis was used to identify independent prognostic features for survival in LGSOC and HGSOC. Adjuvant chemotherapy was given in 99.7% of HGSOC patients versus in 27% of LGSOC (p < 0.0001). The LGSOC patients had greater surgical complexity scores (p < 0.0001), more frequent postoperative ICU/HDU admissions (p = 0.0002), and higher peri-/post-operative morbidity (p < 0.0001) compared to the HGSOC patients. The 5-year OS and progression-free survival (PFS) was 30% and 13% for HGSOC versus 57% and 21.6% for LGSOC, p = 0.016 and p = 0.044, respectively. Surgical complexity (HR 5.3, 95%CI 1.2–22.8, p = 0.024) and complete cytoreduction (HR 62.4, 95% CI 6.8–567.9, p < 0.001) were independent prognostic features for OS in LGSOC. This study demonstrates no clear significant survival advantage of chemotherapy in LGSOC. It highlights the substantial survival benefit of dynamic multi-visceral surgery to achieve complete cytoreduction as the primary treatment for LGSOC patients.

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