TriboGlide® is an Alternative to Silicone Oil-Lubricated Glass Syringes: A 24-Week Study with a Model Protein

2016 ◽  
Author(s):  
LaToya Braun
Keyword(s):  
Silicone Oil ◽  
Model Protein

scholarly journals Silicone Oil-Based Nanoadjuvants as Candidates for a New Formulation of Intranasal Vaccines

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 234
Author(s):  
Agnieszka Razim ◽  
Marcelina Pyclik ◽  
Katarzyna Pacyga ◽  
Sabina Górska ◽  
Jintao Xu ◽  
...  
Keyword(s):  
Silicone Oil ◽  
Storage Conditions ◽  
Igg Antibody ◽  
Mucosal Surfaces ◽  
Model Protein ◽  
Antibody Titers ◽  
Mucosal Vaccines ◽  
New Formulation ◽  
Factor Α

Many conventional vaccines are administered via a needle injection, while most pathogens primarily invade the host via mucosal surfaces. Moreover, protective IgA antibodies are insufficiently induced by parenteral vaccines. Mucosal immunity induces both local and systemic response to pathogens and typically lasts for long periods of time. Therefore, vaccination via mucosal routes has been increasingly explored. However, mucosal vaccines require potent adjuvants to become efficacious. Despite many efforts to develop safe and robust adjuvants for mucosal vaccines, only a few have been approved for use in human formulations. The aim of our study was to design, develop and characterize new silicone oil-based nanoadjuvant candidates for intranasal vaccines with potential to become mucosal adjuvants. We have developed an array of nanoadjuvant candidates (NACs), based on well-defined ingredients. NAC1, 2 and 3 are based on silicone oil, but differ in the used detergents and organic solvents, which results in variations in their droplet size and zeta potential. NACs’ cytotoxicity, Tumor Necrosis Factor α (TNF-α) induction and their effect on antigen engulfment by immune cells were tested in vitro. Adjuvant properties of NACs were verified by intranasal vaccination of mice together with ovalbumin (OVA). NACs show remarkable stability and do not require any special storage conditions. They exhibit bio-adhesiveness and influence the degree of model protein engulfment by epithelial cells. Moreover, they induce high specific anti-OVA IgG antibody titers after two intranasal administrations. Nanoadjuvant candidates composed of silicone oil and cationic detergents are stable, exhibit remarkable adjuvant properties and can be used as adjuvants for intranasal immunization.

Use of viscodissection and silicone oil in vitrectomy for severe diabetic retinopathy

2003 ◽  
Vol 18 (3) ◽  
pp. 121-126
Author(s):  
Grigorian R.A. ◽  
Castellarin A. ◽  
Bhagat N. ◽  
Del Priore ◽  
Von Hagen ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Silicone Oil

Colchicine Uptake and Binding by Human Platelets

1975 ◽  
Vol 34 (03) ◽  
pp. 780-794 ◽  
Author(s):  
Dianne M Kenney ◽  
Francis C Chao ◽  
James L Tullis ◽  
Gail S Conneely
Keyword(s):  
Time Dependence ◽  
Incubation Period ◽  
Binding Sites ◽  
Silicone Oil ◽  
Cold Treatment ◽  
Human Platelets ◽  
Temperature Dependent

SummaryThe uptake and binding of antimitotic alkaloid colchicine has been demonstrated in washed preparations of human platelets. A silicone oil technique was adapted so that both uptake and binding of 14C-colchicine were examined in the same platelet preparations. The time dependence and amount of colchicine taken up and bound by different platelet preparations during a 90 to 120 min incubation period were highly reproducible. Both colchicine uptake and binding by intact platelets, and colchicine binding by preparations of lysed platelets were specific and temperature dependent. Colchicine uptake was slowly reversible. Magnesium and GTP enhanced colchicine binding by lysed platelet preparations but calcium decreased binding.Exposure of platelets to either cold (4° C) or to thrombin, which disrupt platelet microtubules, produced significant increases in colchicine uptake and binding. The thrombin effect was maximal at 37° C and resulted in a greater increase in uptake and binding than that produced by either cold treatment alone or, by cold treatment followed by incubation with thrombin at 37° C. The amount of increase in uptake and binding produced by thrombin was independent of both thrombin (1–5 Units/109 platelets) and colchicine concentrations (1–50 × 10−6M).It is postulated that thrombin may initiate the formation, or make available, colchicine binding sites (microtubule subunits) within platelets.

Biomedical Materials to Repair Retinal Detachments

1985 ◽  
Vol 55 ◽  
Author(s):  
Miguel F. Refojo
Keyword(s):  
Retinal Detachment ◽  
Silicone Rubber ◽  
Methyl Acrylate ◽  
Silicone Oil ◽  
Vitreous Body ◽  
Light Sensitivity ◽  
Scleral Buckling ◽  
Intraocular Injection ◽  
Other Substances

ABSTRACTImplants are essential for the repair of retinal detachments. The implant buckles the wall of the eye and apposes the detached retina with the choroid, thus restoring light sensitivity to the retina. The scleral buckling also relieves traction on the retina from a shrinking vitreous body. The implant materials most commonly used are solid silicone rubber and silicone sponges, but both types have some disadvantages. A poly(hydroxyethyl acrylate-co-methyl acrylate) hydrogel implant with improved properties of softness and antibiotic absorption is also available for retinal detachment surgery. Proliferative vitreoretinopathy involves various conditions of retinal detachment complicated by vitreous fibrosis, which, after vitrectomy, may be treated with intraocular injection of fluids that support the retina against the choroid. For conditions requiring a long-term implant, silicone oil although controversial is the material of choice. Many other substances have been investigated but none better has yet been found.

Assessment of Color Stability of Treated Leathers with Silicone Oil and Polyethylene Glycol

2014 ◽  
Vol 1 (1) ◽  
pp. 24-34
Author(s):  
Alireza K. ◽  
Hossein Ahmadi ◽  
Mohsen Mohammadi
Keyword(s):  
Ascorbic Acid ◽  
Polyethylene Glycol ◽  
Treatment Process ◽  
Color Change ◽  
Silicone Oil ◽  
Accelerated Aging ◽  
Color Stability ◽  
Antioxidant Additive ◽  
Before And After ◽  
Aesthetic Values

Lubricants and leather dressings are the most common treatments of dry and water logged historical leathers. Color change has a great importance during the time and treatment process, due to visual and aesthetic values of historic leather relics. Polyethylene glycol (PEG) and silicone oil (SiO) are frequently used leather dressings in the conservation procedures. Therefore, color stability of treated leathers with PEG and SiO were investigated before and after heat accelerated aging. Moreover, application of ascorbic acid was evaluated as an antioxidant additive for PEG (PEG+AA).Color change after treatment and aging were studied by colorimetry technique in the CIE *L*a*b system. Results indicated to severe color alteration in PEG treated and aged leathers with or without ascorbic acid. Whereas, SiO treated samples showed better stability and minimum color shift after aging. Silicone oil was characterized as the best dressing for historical leathers with compared to PEG and PEG+AA, due to its high stability and aesthetical properties.

Silicone oil removal options after cataract phacoemulsification

2020 ◽  
pp. 98-99
Author(s):  
A.M. Danilov ◽  
◽  
A.G. Grinev ◽  
M.B. Sviridova ◽  
◽  
...  
Keyword(s):  
Silicone Oil ◽  
Oil Removal ◽  
Silicone Oil Removal

Актуальность. Тампонада витреальной полости силиконовым маслом (СМ) или наличие остатков СМ при авитрии являются показаниями к их удалению, которое может быть выполнено различными методиками, нередко после факоэмульсификации катаракты. Цель. Изучить результаты удаления СМ через задний капсулорексис (ЗК) различными методами. 1. Изучить возможность удаления остатков СМ через задний капсулорексис при авитрии. 2. Провести апробацию удаления СМ через ЗК методом эффузии. 3. Провести апробацию удаления СМ через ЗК методом аспирации. Материал и методы. Под наблюдением находилось 18 пациентов, проходивших лечение в СОКБ №1. Результаты. Операции выполнены без осложнений в ближайшем и отдаленном послеоперационном периоде с улучшением зрительных функций. Выводы. 1. Изучены результаты удаления СМ через задний капсулорексис. 2. Удаление остатков СМ через ЗК при авитрии после факоэмульсификации позволяет повысить степень удовлетворенности пациентов результатами хирургического лечения. 3. Проведена апробация удаления СМ через ЗК методом эффузии, что позволяет качественнее удалять СМ, в том числе эмульгированные фрагменты. 4. Проведена апробация удаления СМ через ЗК методом аспирации, что сокращает время операции, позволяет в большем объеме удалять остатки эмульгированного СМ.

Extrascleral Filling Using Endoillumination the First Experiencethe

2020 ◽  
pp. 43-49
Author(s):  
V.Y. Markevich ◽  
◽  
T.A. Imshenetskaya ◽  
O.A. Yarmak ◽  
◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Retinal Detachment ◽  
Rhegmatogenous Retinal Detachment ◽  
Silicone Oil ◽  
Subretinal Fluid ◽  
Crystalline Lens ◽  
Vitreous Cavity ◽  
Macular Area ◽  
General Group ◽  
Anatomical Outcome

Purpose. To study the effectiveness of extrascleral filling (ESF) using endoillumination in the surgical treatment of patients with primary rhegmatogenous retinal detachment (RRD). Material and methods. The material for the study was the data of a comprehensive clinical examination and surgical treatment by ESF method using endoillumination in 17 patients (17 eyes) with RRD. In 7 cases (41%), the macular area was involved in the detachment process. In 5 cases (29.4%), local scleral filling was performed. In the remaining 12 cases (70.6%), the local ESF was supplemented with a circling silicone element. Surgical intervention was supplemented by transscleral drainage of subretinal fluid (SRF) in 10 cases (59%) and pneumatic retinopexy with SF6 gas 50% in 8 cases (48%). Results. In the general group of patients, best corrected visual acuity (BCVA) increased from 0.35 to 0.46. In the subgroup of patients with a detached macular area, the positive dynamics is more pronounced, BCVA increased from 0.1 to 0.28. The progression of proliferative vitreoretinopathy caused the recurrence of retinal detachment in two patients (11.8%). Recurrences were diagnosed after 3 and 5 months, respectively. In both cases, a vitrectomy with tamponade of the vitreous cavity with silicone oil 5000 Cst was performed. The percentage of successful anatomical outcome after the first operation in our study was 82%. The percentage of successful achievement of the final anatomical result was 94%. In two cases, additional injection of SF6 gas into the vitreous cavity was required. Conclusion. This type of surgical treatment is an effective method of surgical treatment of patients with RRD. In our study, the successful anatomical outcome after the first operation was recorded in 82% of patients, which correlates with the data of the authors who also used this method (83–92%). Surgeons who performed surgical treatment using this technique in our study note improved workplace ergonomics when visualizing the fundus using an operating microscope and endoillumination compared with indirect ophthalmoscopy. Other teams of authors came to this conclusion as well. In our study, there were no complications associated with the introduction of a light pipe into the vitreous cavity (iatrogenic crystalline lens injury, endophthalmitis), which indicates the safety of this type of surgical treatment.

Features of cataract surgery in patients with vitreal cavity tamponade with silicone oil

2019 ◽  
Vol 30 (5) ◽  
pp. 61-64
Author(s):  
Y.V. Kudyavtseva ◽  
◽  
L.V. Demakova ◽  
I.A. Gavrilova ◽  
◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Silicone Oil
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