Colon Permeability Data Obtained by Single-Pass Rat Perfusion Model in the Development of Controlled-Release Drug Products

2016 ◽  
Author(s):  
Arik Dahan
Keyword(s):  
Controlled Release ◽  
Single Pass ◽  
Drug Products ◽  
Release Drug ◽  
Perfusion Model ◽  
Permeability Data

Chitosan based Controlled Release Drug Delivery of Mycophenolate Mofetil Loaded in Nanocarriers System: Synthesis and in-vitro evaluation

2021 ◽  
pp. 1-18
Author(s):  
Muhammad Zaman ◽  
Asma Iqbal ◽  
Syed Farhan Haider Rizvi ◽  
Muhammad Ajaz Hussain ◽  
Talha Jamshaid ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mycophenolate Mofetil ◽  
Controlled Release ◽  
In Vitro Evaluation ◽  
System Synthesis ◽  
Release Drug

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

scholarly journals Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

Materials ◽  
2018 ◽  
Vol 11 (2) ◽  
pp. 281 ◽  
Author(s):  
Yong Xie ◽  
Xinxin Ma ◽  
Xujie Liu ◽  
Qingming Long ◽  
Yu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Drug ◽  
Release Drug ◽  
Anti Cancer ◽  
Carrier Free

scholarly journals PREPARATION AND EVALUATION OF CHITOSAN SODIUM ALGINATE CARBAMAZEPINE MICROSPHERES

2017 ◽  
Vol 10 (3) ◽  
pp. 271 ◽  
Author(s):  
Sreeja C Nair ◽  
Karthika Ramesh ◽  
Krishnapriya M ◽  
Asha Paul
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Controlled Release ◽  
Sodium Alginate ◽  
Physical Parameters ◽  
Effective Management ◽  
Release Drug ◽  
Conventional Drug ◽  
Preparation And Evaluation ◽  
Evaluation Parameters

ABSTRACTObjective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres forthe purpose of controlled release for the treatment of epilepsy to avoid the possible side effects.Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into thenatural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies.Results: The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within theacceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation(CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy.Conclusion: The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.Keywords: Carbamazepine, Sodium alginate microspheres, Particle size.

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