PREPARATION AND EVALUATION OF CHITOSAN SODIUM ALGINATE CARBAMAZEPINE MICROSPHERES

ABSTRACTObjective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres forthe purpose of controlled release for the treatment of epilepsy to avoid the possible side effects.Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into thenatural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies.Results: The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within theacceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation(CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy.Conclusion: The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.Keywords: Carbamazepine, Sodium alginate microspheres, Particle size.

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Preparation of a controlled release drug delivery system of indomethacin: Effect of process equipment, particle size of indomethacin, and size of the nonpareil seeds

Drug Development and Industrial Pharmacy ◽

10.3109/03639048909043669 ◽

1989 ◽

Vol 15 (8) ◽

pp. 1137-1159 ◽

Cited By ~ 11

Author(s):

Shun Por Li ◽

Kenneth M. Feld ◽

Chana R. Kowarski

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Controlled Release ◽

Drug Delivery System ◽

Delivery System ◽

Process Equipment ◽

Release Drug

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Chitosan based Controlled Release Drug Delivery of Mycophenolate Mofetil Loaded in Nanocarriers System: Synthesis and in-vitro evaluation

Drug Development and Industrial Pharmacy ◽

10.1080/03639045.2021.1892739 ◽

2021 ◽

pp. 1-18

Author(s):

Muhammad Zaman ◽

Asma Iqbal ◽

Syed Farhan Haider Rizvi ◽

Muhammad Ajaz Hussain ◽

Talha Jamshaid ◽

...

Keyword(s):

Drug Delivery ◽

Mycophenolate Mofetil ◽

Controlled Release ◽

In Vitro Evaluation ◽

System Synthesis ◽

Release Drug

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Dried Molasses as a Direct Compression Matrix for Oral Controlled Release Drug Delivery II: Release Mechanism and Characteristics of Theophylline from a Molasses-Hpmc Matrix

Drug Development and Industrial Pharmacy ◽

10.3109/03639048909058527 ◽

1989 ◽

Vol 15 (5) ◽

pp. 705-718 ◽

Cited By ~ 3

Author(s):

Samuel D. Uko-nne ◽

Robert W. Mendes ◽

Sunil S. Jambhekar

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Release Mechanism ◽

Direct Compression ◽

Release Drug

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Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

Materials ◽

10.3390/ma11020281 ◽

2018 ◽

Vol 11 (2) ◽

pp. 281 ◽

Cited By ~ 5

Author(s):

Yong Xie ◽

Xinxin Ma ◽

Xujie Liu ◽

Qingming Long ◽

Yu Wang ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Cancer Drug ◽

Release Drug ◽

Anti Cancer ◽

Carrier Free

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Comprehensive Review on Hydrogels

Current Drug Delivery ◽

10.2174/1567201818666210601155558 ◽

2021 ◽

Vol 18 ◽

Author(s):

Hitesh Chopra ◽

Inderbir Singh ◽

Sandeep Kumar ◽

Tanima Bhattacharya ◽

Md. Habibur Rahman ◽

...

Keyword(s):

Drug Delivery ◽

Wound Healing ◽

Controlled Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Bone Engineering ◽

Comprehensive Review ◽

Therapeutic Benefits ◽

Conventional Drug ◽

Repeated Dosing

: The conventional drug delivery systems have a long list of issues of repeated dosing and toxicity arising due to it. The hydrogels are the answer to them and offer a result that minimizes such activities and optimizes therapeutic benefits. The hydrogels proffer tunable properties that can withstand degradation, metabolism, and controlled release moieties. Some of the areas of applications of hydrogels involve wound healing, ocular systems, vaginal gels, scaffolds for tissue, bone engineering, etc. They consist of about 90% of the water that makes them suitable bio-mimic moiety. Here, we present a birds-eye view of various perspectives of hydrogels, along with their applications.

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Optimizing Oral Controlled Release Drug Delivery Systems Using Experimental Designs

Intellectual Property Rights Open Access ◽

10.4172/2375-4516.1000142 ◽

2015 ◽

Vol 03 (02) ◽

Author(s):

Sahilhusen I Jethara ◽

Mukesh R Patel

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Experimental Designs ◽

Release Drug

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Data Fitting for Two- and Three-Dimensional Controlled-Release Drug-Delivery Models

Closed-Form Solutions for Drug Transport through Controlled-Release Devices in Two and Three Dimensions ◽

10.1002/9781119055976.ch14 ◽

2015 ◽

pp. 233-258

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Three Dimensional ◽

Data Fitting ◽

Release Drug ◽

Delivery Models

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Sodium Alginate Nanoparticles of Isoniazid: Preparation and Evaluation

International Journal of Pharmaceutical Sciences and Drug Research ◽

10.25004/ijpsdr.2019.110616 ◽

2019 ◽

Vol 11 (06) ◽

Author(s):

Sumit Kumar ◽

Dinesh Chandra Bhatt

Keyword(s):

Particle Size ◽

Sodium Alginate ◽

Encapsulation Efficiency ◽

Drug Loading ◽

Average Particle Size ◽

Average Particle ◽

In Vitro Drug Release ◽

Ionotropic Gelation ◽

Preparation And Evaluation

Fabrication and evaluation of the Isoniazid loaded sodium alginate nanoparticles (NPs) was main objective of current investigation. These NPs were engineered using ionotropic gelation technique. The NPs fabricated, were evaluated for average particle size, encapsulation efficiency, drug loading, and FTIR spectroscopy along with in vitro drug release. The particle size, drug loading and encapsulation efficiency of fabricated nanoparticles were ranging from 230.7 to 532.1 nm, 5.88% to 11.37% and 30.29% to 59.70% respectively. Amongst all batches studied formulation F-8 showed the best sustained release of drug at the end of 24 hours.

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