Chronic co-administration of mGluR5 antagonist (MTEP) with COX-2 inhibitor (NS398) affects DSCAM expression in prefrontal cortex and hippocampus in C57Bl/6J mice

MOMAST(®) HY100 and MOMAST(®) HP30 are polyphenolic liquid complexes from olive pressing juice with a total polyphenolic content of 100 g/kg (at least 50% as hydroxytyrosol) and 36 g/kg (at least 30% as hydroxytyrosol), respectively. We investigated the potential protective role of MOMAST(®) HY100 and MOMAST(®) HP30 on isolated rat colon, liver, heart, and prefrontal cortex specimens treated with Escherichia coli lipopolysaccharide (LPS), a validated ex vivo model of inflammation, by measuring the production of prostaglandin (PG)E2, 8-iso-PGF2α, lactate dehydrogenase (LDH), as well as cyclooxygenase (COX)-2, tumor necrosis factor α (TNFα), and inducible nitric oxide synthase (iNOS) mRNA levels. MOMAST(®) HY100 decreased LPS-stimulated PGE2 and LDH levels in all tested tissues. Following treatment with MOMAST(®) HY100, we found a significant reduction in iNOS levels in prefrontal cortex and heart specimens, COX-2 and TNFα mRNA levels in heart specimens, and 8-iso-PGF2α levels in liver specimens. On the other hand, MOMAST(®) HP30 was found to blunt COX-2, TNFα, and iNOS mRNA levels, as well as 8-iso-PGF2α in cortex, liver, and colon specimens. MOMAST(®) HP30 was also found to decrease PGE2 levels in liver specimens, while it decreased iNOS mRNA, LDH, and 8-iso-PGF2α levels in heart specimens. Both MOMAST(®) HY100 and MOMAST(®) HP30 exhibited protective effects on multiple inflammatory and oxidative stress pathways.

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Co-administration of COX-2 inhibitor NS-398 enhances antidepressant effect of mGluR5 antagonist MTEP in mice

European Neuropsychopharmacology ◽

10.1016/s0924-977x(17)30077-9 ◽

2017 ◽

Vol 27 ◽

pp. S9-S10

Author(s):

P. Pańczyszyn-Trzewik ◽

P. Misztak ◽

M. Sowa-Kućma ◽

B. Szewczyk ◽

G. Nowak ◽

...

Keyword(s):

Antidepressant Effect ◽

Mglur5 Antagonist ◽

Cox 2

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Alteration of CYP2E1, DBN1, DNMT1, miRNA-335, miRNA-21, c-Fos and Cox-2 gene expression in prefrontal cortex of rats’ offspring submitted to prenatal ethanol exposure during their neurodevelopment and the preventive role of nancocurcumin administration: A histological, ultrastructural and molecular study

Journal of Chemical Neuroanatomy ◽

10.1016/j.jchemneu.2021.101940 ◽

2021 ◽

pp. 101940

Author(s):

Heba Mohamed Ali Labib

Keyword(s):

Gene Expression ◽

Prefrontal Cortex ◽

Molecular Study ◽

Ethanol Exposure ◽

Prenatal Ethanol Exposure ◽

Cox 2 ◽

Preventive Role

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(171) Effects of thermal and nerve injury on COX-2 expression in the prefrontal cortex of rat brain

Journal of Pain ◽

10.1016/j.jpain.2017.02.078 ◽

2017 ◽

Vol 18 (4) ◽

pp. S19

Author(s):

W. Stacey ◽

N. Sosanya ◽

A. Trevinom ◽

R. Christy ◽

B. Cheppudira

Keyword(s):

Prefrontal Cortex ◽

Rat Brain ◽

Nerve Injury ◽

Cox 2

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Effects of acute mGluR7 PAM on changes in short-time plasticity and mGluR7 levels after chronic treatment with mGluR5 antagonist and COX-2 inhibitor

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2018.11.360 ◽

2019 ◽

Vol 29 ◽

pp. S221 ◽

Cited By ~ 1

Author(s):

B. Bobula ◽

K. Tokarski ◽

M. Sowa-Kućma ◽

P. Misztak ◽

A. Pilc ◽

...

Keyword(s):

Chronic Treatment ◽

Mglur5 Antagonist ◽

Cox 2 ◽

Short Time

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Effects of maternal exposure to arsenic on social behavior and related gene expression in F2 male mice

Environmental Health and Preventive Medicine ◽

10.1186/s12199-021-00956-y ◽

2021 ◽

Vol 26 (1) ◽

Author(s):

Soe-Minn Htway ◽

Takehiro Suzuki ◽

Sanda Kyaw ◽

Keiko Nohara ◽

Tin-Tin Win-Shwe

Keyword(s):

Gene Expression ◽

Prefrontal Cortex ◽

Social Behavior ◽

Tap Water ◽

Arsenic Exposure ◽

Male Mice ◽

Related Gene ◽

Gene Expressions ◽

Males And Females ◽

Cox 2

Abstract Background Arsenic is a developmental neurotoxicant. It means that its neurotoxic effect could occur in offspring by maternal arsenic exposure. Our previous study showed that developmental arsenic exposure impaired social behavior and serotonergic system in C3H adult male mice. These effects might affect the next generation with no direct exposure to arsenic. This study aimed to detect the social behavior and related gene expression changes in F2 male mice born to gestationally arsenite-exposed F1 mice. Methods Pregnant C3H/HeN mice (F0) were given free access to tap water (control mice) or tap water containing 85 ppm sodium arsenite from days 8 to 18 of gestation. Arsenite was not given to F1 or F2 mice. The F2 mice were generated by mating among control F1 males and females, and arsenite-F1 males and females at the age of 10 weeks. At 41 weeks and 74 weeks of age respectively, F2 males were used for the assessment of social behavior by a three-chamber social behavior apparatus. Histological features of the prefrontal cortex were studied by ordinary light microscope. Social behavior-related gene expressions were determined in the prefrontal cortex by real time RT-PCR method. Results The arsenite-F2 male mice showed significantly poor sociability and social novelty preference in both 41-week-old group and 74-week-old group. There was no significant histological difference between the control mice and the arsenite-F2 mice. Regarding gene expression, serotonin receptor 5B (5-HT 5B) mRNA expression was significantly decreased (p < 0.05) in the arsenite-F2 male mice compared to the control F2 male mice in both groups. Brain-derived neurotrophic factor (BDNF) and dopamine receptor D1a (Drd1a) gene expressions were significantly decreased (p < 0.05) only in the arsenite-F2 male mice of the 74-week-old group. Heme oxygenase-1 (HO-1) gene expression was significantly increased (p < 0.001) in the arsenite-F2 male mice of both groups, but plasma 8-hydroxy-2′-deoxyguanosine (8-OHdG) and cyclooxygenase-2 (COX-2) gene expression were not significantly different. Interleukin-1β (IL-1β) mRNA expression was significantly increased only in 41-week-old arsenite-F2 mice. Conclusions These findings suggest that maternal arsenic exposure affects social behavior in F2 male mice via serotonergic system in the prefrontal cortex. In this study, COX-2 were not increased although oxidative stress marker (HO-1) was increased significantly in arsnite-F2 male mice.

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