SENTINEL LYMPH NODES MAPPING WITH INDOCYANINE GREEN IN CERVICAL CANCER STAGE IAI – IIB : A SINGLE CENTER EXPERIENCE

2017 ◽  
Author(s):  
Ju-Hyun Kim
Keyword(s):  
Cervical Cancer ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Sentinel Lymph Nodes ◽  
Cancer Stage ◽  
Single Center ◽  
Single Center Experience

scholarly journals Sentinel Lymph Nodes Mapping in Cervical Cancer a Comprehensive Review

2016 ◽  
Vol 27 (1) ◽  
pp. 154-158 ◽  
Author(s):  
Yasser Diab
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
High Sensitivity ◽  
Sentinel Lymph Node Mapping ◽  
Sentinel Lymph Nodes ◽  
Detection Rates ◽  
Lymph Node Mapping

ObjectiveA comprehensive literature search for more recent studies pertaining to sentinel lymph node mapping in the surveillance of cervical cancer to assess if sentinel lymph node mapping has sensitivity and specificity for evaluation of the disease; assessment of posttreatment response and disease recurrence in cervical cancer.Materials and MethodsThe literature review has been constructed on a step wise study design that includes 5 major steps. This includes search for relevant publications in various available databases, application of inclusion and exclusion criteria for the selection of relevant publications, assessment of quality of the studies included, extraction of the relevant data and coherent synthesis of the data.ResultsThe search yielded numerous studies pertaining to sentinel lymph node mapping, especially on the recent trends, comparison between various modalities and evaluation of the technique. Evaluation studies have appraised high sensitivity, high negative predictive values and low false-negative rate for metastasis detection using sentinel lymph node mapping. Comparative studies have established that of all the modalities for sentinel lymph node mapping, indocyanine green sentinel lymph node mapping has higher overall and bilateral detection rates. Corroboration of the deductions of these studies further establishes that the sentinel node detection rate and sensitivity are strongly correlated to the method or technique of mapping and the history of preoperative neoadjuvant chemotherapy.ConclusionsThe review takes us to the strong conclusion that sentinel lymph node mapping is an ideal technique for detection of sentinel lymph nodes in cervical cancer patients with excellent detection rates and high sensitivity. The review also takes us to the supposition that a routine clinical evaluation of sentinel lymph nodes is feasible and a real-time florescence mapping with indocyanine green dye gives better statistically significant overall and bilateral detection than methylene blue.

scholarly journals Indocyanine green can stand alone in detecting sentinel lymph nodes in cervical cancer

2018 ◽  
Vol 46 (12) ◽  
pp. 4885-4897 ◽  
Author(s):  
Qurat Ulain ◽  
Lu Han ◽  
Qian Wu ◽  
Lanbo Zhao ◽  
Qi Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Human Serum ◽  
Detection Rate ◽  
Sentinel Lymph Nodes ◽  
Detection Rates ◽  
Pubmed Database

Objectives The effectiveness of indocyanine green (ICG) dye for detecting sentinel lymph nodes (SLNs) in cervical cancer compared with other tracers is unknown. This study aimed to assess the validity of ICG dye in detecting SLNs in cervical cancer preoperatively. Methods We performed a literature search for identifying eligible articles from PubMed database using the search terms “cervical cancer”, “sentinel lymph node”, “indocyanine green”, “blue dyes”, “human serum albumin”, and “technetium-99 radiocolloid”. We performed a meta-analysis. Comparison of the overall, bilateral, and unilateral detection rates of the different tracers was the primary goal. Comparison of the false-negative rate among the tracers was the secondary goal. Results Only eight retrospective studies including 661 patients were included. ICG versus combinations of three other tracers showed significantly higher bilateral and unilateral detection rates, but no difference in the overall rate of detecting SLNs. ICG had a higher bilateral detection rate than blue dye and technetium-99. Absorbing human serum albumin into ICG as a lymphatic tracer did not show a difference in detection rate compared with ICG alone. Conclusions ICG is superior and better than other tracers, and absorbing human serum albumin as a lymphatic tracer is not required in patients with cervical cancer.

scholarly journals Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique

2021 ◽  
Vol 10 (21) ◽  
pp. 4849
Author(s):  
Mustafa Zelal Muallem ◽  
Ahmad Sayasneh ◽  
Robert Armbrust ◽  
Jalid Sehouli ◽  
Andrea Miranda
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
False Negative ◽  
Standard Of Care ◽  
Sentinel Lymph Nodes ◽  
Lymph Node Staging ◽  
Open Approach

(1) Background: Sentinel lymph node staging (SLN) with indocyanine green (ICG) in cervical cancer is the standard of care in most national and international guidelines. However, the vast majority of relevant studies about the safety and feasibility of this method are conducted on minimally invasive surgery; (2) Methods: This study is a retrospective analysis of a retrospective collected database of 76 consecutive patients with cervical cancers, who were operated laparoscopically (50%), or laparotomy (50%). Sentinel nodes were defined as the ICG-positive pelvic nodes in the first and second echelons. False negative cases were defined as positive non-sentinel lymph nodes despite successful sentinel mapping or failed mapping bilaterally by per-patient assessment or unilaterally by pelvic sidewall assessment; (3) Results: Regardless of the approach (open or laparoscopic), the SLN technique achieved a total sensitivity, specificity, and negative predictive value (NPV) of 94.7%, 98.6%, and 94.7%, respectively in the entire sample. The bilateral detection rate was as high as 93.4% with identical results in both approaches. The sensitivity and NPV for SNL in open surgery was found to be similar to minimal access surgery; (4) Conclusions: ICG and SPY-PHI technique is a reliable tool to detect sentinel lymph nodes in cervical cancer during laparotomy.

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