The detection of sentinel lymph nodes in laparoscopic surgery for uterine cervical cancer using 99m-technetium-tin colloid, indocyanine green, and blue dye

ObjectiveA comprehensive literature search for more recent studies pertaining to sentinel lymph node mapping in the surveillance of cervical cancer to assess if sentinel lymph node mapping has sensitivity and specificity for evaluation of the disease; assessment of posttreatment response and disease recurrence in cervical cancer.Materials and MethodsThe literature review has been constructed on a step wise study design that includes 5 major steps. This includes search for relevant publications in various available databases, application of inclusion and exclusion criteria for the selection of relevant publications, assessment of quality of the studies included, extraction of the relevant data and coherent synthesis of the data.ResultsThe search yielded numerous studies pertaining to sentinel lymph node mapping, especially on the recent trends, comparison between various modalities and evaluation of the technique. Evaluation studies have appraised high sensitivity, high negative predictive values and low false-negative rate for metastasis detection using sentinel lymph node mapping. Comparative studies have established that of all the modalities for sentinel lymph node mapping, indocyanine green sentinel lymph node mapping has higher overall and bilateral detection rates. Corroboration of the deductions of these studies further establishes that the sentinel node detection rate and sensitivity are strongly correlated to the method or technique of mapping and the history of preoperative neoadjuvant chemotherapy.ConclusionsThe review takes us to the strong conclusion that sentinel lymph node mapping is an ideal technique for detection of sentinel lymph nodes in cervical cancer patients with excellent detection rates and high sensitivity. The review also takes us to the supposition that a routine clinical evaluation of sentinel lymph nodes is feasible and a real-time florescence mapping with indocyanine green dye gives better statistically significant overall and bilateral detection than methylene blue.

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SENTINEL LYMPH NODES MAPPING WITH INDOCYANINE GREEN IN CERVICAL CANCER STAGE IAI – IIB : A SINGLE CENTER EXPERIENCE

10.26226/morressier.599bdc79d462b80296ca0aed ◽

2017 ◽

Author(s):

Ju-Hyun Kim

Keyword(s):

Cervical Cancer ◽

Lymph Nodes ◽

Indocyanine Green ◽

Sentinel Lymph Nodes ◽

Cancer Stage ◽

Single Center ◽

Single Center Experience

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Comparison of Indocyanine Green Fluorescence and Blue Dye Methods in Detection of Sentinel Lymph Nodes in Early-Stage Breast Cancer

Annals of Surgical Oncology ◽

10.1245/s10434-017-6186-7 ◽

2017 ◽

Vol 24 (S3) ◽

pp. 581-582 ◽

Cited By ~ 1

Author(s):

Vassilis Pitsinis ◽

Gordon C. Wishart

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Indocyanine Green ◽

Early Stage ◽

Sentinel Lymph Nodes ◽

Early Stage Breast Cancer ◽

Blue Dye ◽

Green Fluorescence ◽

Indocyanine Green Fluorescence

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Indocyanine green can stand alone in detecting sentinel lymph nodes in cervical cancer

Journal of International Medical Research ◽

10.1177/0300060518803041 ◽

2018 ◽

Vol 46 (12) ◽

pp. 4885-4897 ◽

Cited By ~ 5

Author(s):

Qurat Ulain ◽

Lu Han ◽

Qian Wu ◽

Lanbo Zhao ◽

Qi Wang ◽

...

Keyword(s):

Cervical Cancer ◽

Human Serum Albumin ◽

Serum Albumin ◽

Lymph Nodes ◽

Indocyanine Green ◽

Human Serum ◽

Detection Rate ◽

Sentinel Lymph Nodes ◽

Detection Rates ◽

Pubmed Database

Objectives The effectiveness of indocyanine green (ICG) dye for detecting sentinel lymph nodes (SLNs) in cervical cancer compared with other tracers is unknown. This study aimed to assess the validity of ICG dye in detecting SLNs in cervical cancer preoperatively. Methods We performed a literature search for identifying eligible articles from PubMed database using the search terms “cervical cancer”, “sentinel lymph node”, “indocyanine green”, “blue dyes”, “human serum albumin”, and “technetium-99 radiocolloid”. We performed a meta-analysis. Comparison of the overall, bilateral, and unilateral detection rates of the different tracers was the primary goal. Comparison of the false-negative rate among the tracers was the secondary goal. Results Only eight retrospective studies including 661 patients were included. ICG versus combinations of three other tracers showed significantly higher bilateral and unilateral detection rates, but no difference in the overall rate of detecting SLNs. ICG had a higher bilateral detection rate than blue dye and technetium-99. Absorbing human serum albumin into ICG as a lymphatic tracer did not show a difference in detection rate compared with ICG alone. Conclusions ICG is superior and better than other tracers, and absorbing human serum albumin as a lymphatic tracer is not required in patients with cervical cancer.

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