Investigating the dynamics of the telomeric long noncoding RNA TERRA and the telomerase RNA hTR in human cancer cells

2020 ◽  
Author(s):  
Emilio Cusanelli
Keyword(s):  
Cancer Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Cancer ◽  
Telomerase Rna ◽  
Human Cancer Cells

scholarly journals ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells

2008 ◽  
Vol 68 (13) ◽  
pp. 5309-5317 ◽  
Author(s):  
Bradley A. Stohr ◽  
Elizabeth H. Blackburn
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Telomerase Rna ◽  
Human Cancer Cells

scholarly journals Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR

RNA ◽  
2007 ◽  
Vol 13 (6) ◽  
pp. 890-898 ◽  
Author(s):  
W. P. Tsang ◽  
T. W.L. Wong ◽  
A. H.H. Cheung ◽  
C. N.N. Co ◽  
T. T. Kwok
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Noncoding Rna ◽  
Human Cancer ◽  
Human Cancer Cells

scholarly journals Telomerase Reverse Transcriptase Is Required for the Localization of Telomerase RNA to Cajal Bodies and Telomeres in Human Cancer Cells

2008 ◽  
Vol 19 (9) ◽  
pp. 3793-3800 ◽  
Author(s):  
Rebecca L. Tomlinson ◽  
Eladio B. Abreu ◽  
Tania Ziegler ◽  
Hinh Ly ◽  
Christopher M. Counter ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Cancer Cells ◽  
Human Cancer ◽  
Telomere Maintenance ◽  
Cajal Body ◽  
Cajal Bodies ◽  
Telomerase Reverse Transcriptase ◽  
Telomerase Rna ◽  
Human Cancer Cells ◽  
Essential Components

Telomere maintenance by telomerase is critical for the unlimited division potential of most human cancer cells. The two essential components of human telomerase, telomerase RNA (hTR) and telomerase reverse transcriptase (hTERT), are recruited from distinct subnuclear sites to telomeres during S phase. Throughout the remainder of the cell cycle hTR is found primarily in Cajal bodies. The localization of hTR to Cajal bodies and telomeres is specific to cancer cells where telomerase is active and is not observed in primary cells. Here we show that the trafficking of hTR to both telomeres and Cajal bodies depends on hTERT. RNA interference–mediated depletion of hTERT in cancer cells leads to loss of hTR from both Cajal bodies and telomeres without affecting hTR levels. In addition, expression of hTERT in telomerase-negative cells (including primary and ALT cancer cell lines) induces hTR to localize to both sites. Factors that did not stimulate hTR localization in our experiments include increased hTR RNA levels and Cajal body numbers, and expression of SV40 large T antigen and oncogenic Ras. Our findings suggest that the trafficking of telomerase to Cajal bodies and telomeres in cancer cells correlates with and depends on the assembly of the enzyme.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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