The distance between the embryo and yolk sac associated with inhibin A in the first-trimester pregnancy – which is the novelty?

2019 ◽  
Vol 1 (67) ◽  
pp. 13
Author(s):  
Carmen Elena Bucuri ◽  
Răzvan  Ciortea ◽  
Andrei Mihai Malutan ◽  
Cristian Iuhaș ◽  
Maria Rada ◽  
...  
2020 ◽  
Vol 15 (1) ◽  
pp. 39-42
Author(s):  
Anupama Bhattarai ◽  
Gehanath Baral

Aims: To evaluate yolk sac diameter as a predictor of first trimester pregnancy outcome. Methods: This was a prospective observational study conducted at Paropakar Maternity and Women’s Hospital from October 2017 to October 2018. Pregnant women in between seven and ten weeks of gestation were enrolled. Transabdominal sonography was performed to measure yolk sac diameter and followed up till 12 weeks of gestation to see the outcome. Sensitivity, specificity, positive predictive value and negative predictive value were calculated for yolk sac diameter with regards to abnormal pregnancy outcome. Results: There were 80 cases enrolled and a significant positive correlation was found between yolk sac diameter and gestational age. Abnormal yolk sac diameter, irrespective of gestational age, had sensitivity of 92.95%, specificity 66.66%, positive predictive value 95.6% and negative predictive value of 54.54% in predicting abnormal pregnancy outcome. Conclusions: The measurement of yolk sac diameter between seventh and tenth weeks of gestation can predict first trimester pregnancy outcome. This is useful while counseling pregnant women regarding risk of abnormal outcome and need for follow up ultrasonography. Keywords: first trimester; pregnancy outcome; prognostic factor; yolk sac diameter


Author(s):  
Fotios K. Varelas ◽  
Nicolaos M. Prapas ◽  
Ren-Ing Liang ◽  
Ioannis M. Prapas ◽  
Georgios A. Makedos

Author(s):  
Waleed M. Tawfik

Background: Accurate differentiation between normal pregnancy and pregnancy loss in early gestation remains a clinical challenge-previous studies have described the association between embryonic well-beings and the characteristics of gestational sac. The aim of the study was to evaluate the yolk sac size and embryonic heart rate as a prognostic factor for the first trimester pregnancy outcome.Methods: This was a prospective cohort observesional study. It included 52 pregnant women in their first trimester from 6 week till 12 weeks gestation. Transvaginal sonographic examination after explanation and agreement of each patient. All pregnancies were followed for their pregnancy outcome after completion of 12 weeks. The adverse outcome was spontaneous miscarriage occurring before or at 12 weeks of gestation. These patients allocated into four study groups: according to gestational age at presentation and pregnancy outcome. Group I included women who were examined during (6-7 weeks+6 days). Group II included women who were examined during (8-9 weeks+6 days). Group III included women who were examined during (10-12 weeks). Group IV included women who had their pregnancies resulted into first trimester spontaneous miscarriage.Results: The validity of YS diameter regarding the prognosis of first trimester pregnancy outcome shows that; YSD had 100% specificity and 97.8% sensitivity in prediction of miscarriage. Regarding embryonic heartbeat, there was a statistically significant difference between group IV and the other groups. There was embryonic bradycardia in the miscarriage group. EHR had a sensitivity of 97.5% and specificity of 100% in prediction of first trimester pregnancy outcome.Conclusions: Abnormal yolk sac diameter, in the form of small, enlarged, absent or irregular yolk sac, and embryonic bradycardia are associated with poor pregnancy outcome.


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