scholarly journals Clinical-diagnostic significance of the level of lactacidemia in horse colic

2021 ◽  
Vol 1 (34) ◽  
pp. 10
Author(s):  
Valentin Alexandru Duţulescu ◽  
Maria Roşca ◽  
Mario Codreanu
Keyword(s):  
Diagnostic Significance ◽  
Clinical Diagnostic

The clinical diagnostic significance of serum antichondrocyte membrane antibodies in osteoarthritis

1988 ◽  
Vol 23 (1-2) ◽  
pp. 50-51 ◽  
Author(s):  
M. Németh-Csóka ◽  
C. Paróczai ◽  
Th. Mészáros
Keyword(s):  
Diagnostic Significance ◽  
Clinical Diagnostic

scholarly journals Oxidative Stress - Clinical Diagnostic Significance

2008 ◽  
Vol 27 (4) ◽  
pp. 409-425 ◽  
Author(s):  
Mirjana Đukić ◽  
Milica Ninković ◽  
Marina Jovanović
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Cell Function ◽  
Oxidant Stress ◽  
Membrane Damage ◽  
Point Of View ◽  
Pathophysiological Mechanism ◽  
Diagnostic Significance ◽  
Clinical Diagnostic ◽  
Antioxidative Enzyme Activities

Oxidative Stress - Clinical Diagnostic SignificanceElevated free radical production and/or insufficient antioxidative defense results in cellular oxidant stress responses. Sustained and/or intense oxidative insults can overcome cell defenses resulting in accumulated damage to macromolecules, leading to loss of cell function, membrane damage, and ultimately to cell death. Oxidative stress (OS) can result from conditions including excessive physical stress, exposure to environmental pollution and xenobiotics, and smoking. Oxidative stress, as a pathophysiological mechanism, has been linked to numerous pathologies, poisonings, and the ageing process. Reactive oxygen species and reactive nitrogen species, endogenously or exogenously produced, can readily attack all classes of macromolecules (proteins, DNA, unsaturated fatty acid). The disrupted oxidative-reductive milieu proceeds via lipid peroxidation, altered antioxidative enzyme activities and depletion of non-enzymatic endogenous antioxidants, several of which can de detected in the pre-symptomatic phase of many diseases. Therefore, they could represent markers of altered metabolic and physiological homeostasis. Accordingly, from the point of view of routine clinical-diagnostic practice, it would be valuable to routinely analyze OS status parameters to earlier recognize potential disease states and provide the basis for preventative advance treatment with appropriate medicines.

The clinical diagnostic significance of cerebrospinal fluid d‐lactate for bacterial meningitis

2012 ◽  
Vol 413 (19-20) ◽  
pp. 1512-1515 ◽  
Author(s):  
Zengqiang Chen ◽  
Yumin Wang ◽  
Aibing Zeng ◽  
Lijiang Chen ◽  
Ruihao Wu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Diagnostic Significance ◽  
Clinical Diagnostic

scholarly journals Association Between Circular RNAs and Intracranial Aneurysm Rupture Under the Synergistic Effect of Individual Environmental Factors

2021 ◽  
Vol 12 ◽  
Author(s):  
Qing Huang ◽  
Yi Sun ◽  
Qiuyu Huang ◽  
Yile Zeng ◽  
Shaowei Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Environmental Factors ◽  
Intracranial Aneurysm ◽  
Intracranial Aneurysms ◽  
Synergistic Effects ◽  
Aneurysm Rupture ◽  
Circular Rnas ◽  
Diagnostic Significance ◽  
Multiplicative Interaction ◽  
Clinical Diagnostic

Introduction: To study the association between specific circular RNAs and rupture of intracranial aneurysm. To explore its clinical diagnostic significance and synergistic effects with individual environmental influencing factors.Methods: Three hundred and forty seven cases and controls were included in this study. Multivariate analysis was used to explore the main individual environmental factors. Intracranial aneurysm rupture related circular RNAs screened based on sequencing was verified in peripheral blood by PCR. ROC curve, logistic regression model and fork analysis were used to study the association, diagnostic values, and synergistic effects of circular RNA with intracranial aneurysms and individual environmental factors.Results: Smoking, hair dyeing, sitting time ≥6 h/day, single animal oil intake and hypertension are the main risk factors for intracranial aneurysm rupture; People with higher education, sleeping time ≥7 h/day, tea drinking, diabetes, higher levels of (hemoglobin, low density lipoprotein, serum calcium, and apolipoprotein-A1) have a low risk of intracranial aneurysm rupture. Hsa_circ_0008433 and hsa_circ_0001946 are closely related to intracranial aneurysm rupture and have certain clinical diagnostic significance (AUC = 0.726; 95% CI: 0.668~0.784). Hsa_circ_0008433 (OR = 0.497, 95% CI: 0.338~0.731), hsa_circ_0001946 (OR = 0.682, 95% CI: 0.509~0.914) were independent epigenetic factors affecting intracranial aneurysm rupture, and have a multiplicative interaction with age (OR = 3.052, 95% CI: 1.006~9.258).Conclusions: Low expressions of hsa_circ_0008433 and hsa_circ_0001946 are risk factors for intracranial aneurysms rupture and have good clinical diagnostic value. There was a multiplicative interaction between epigenetic score and age. The older and the higher the epigenetic score was, the more likely to have intracranial aneurysm rupture.

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