scholarly journals Zeolitic Imidazolate Framework Nanoencapsulation of CpG for Stabilization and Enhancement of Immunoadjuvancy

2021 ◽  
Author(s):  
Olivia R. Brohlin ◽  
Ryanne E. Ehrman ◽  
Fabian C. Herbert ◽  
Yalini H. Wijesundara ◽  
Arun Raja ◽  
...  
Keyword(s):  
Thermal Degradation ◽  
Cell Activation ◽  
State Of The Art ◽  
Metal Organic Frameworks ◽  
B Cell Activation ◽  
Zeolitic Imidazolate Framework ◽  
Current State ◽  
Metal Organic ◽  
Particulate Delivery ◽  
Nuclease Degradation

Metal-organic frameworks (MOFs) have been used to improve vaccine formulations by stabilizing proteins and protecting them against thermal degradation. This has led to increased 2 immunogenicity of these proteinaceous therapeutics. In this work we show that MOFs can also be used to protect the ssDNA oligomer, CpG, to increase its immunoadjuvancy. By encapsulating phosphodiester CpG in the zinc-based MOF, ZIF-8, the DNA oligomer is protected from nuclease degradation and exhibits improved cellular uptake. As a result, we have been able to achieve drastically enhanced B-cell activation in splenocyte cultures comparable to the current state-of-the-art, phosphorothioate CpG. Furthermore, we have made a direct comparison of micro- and nano-sized MOF for the optimization of particulate delivery of immunoadjuvants to maximize immune activation.

scholarly journals Recent Applications and Newly Developed Strategies of Solid-Phase Microextraction in Contaminant Analysis: Through the Environment to Humans

Separations ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 54 ◽  
Author(s):  
Naccarato ◽  
Tagarelli
Keyword(s):  
Solid Phase Microextraction ◽  
State Of The Art ◽  
Solid Phase ◽  
Metal Organic Frameworks ◽  
Clinical Analysis ◽  
Emerging Pollutants ◽  
Current State ◽  
Technological Developments ◽  
Metal Organic ◽  
Future Potential

The present review aims to describe the recent and most impactful applications in pollutant analysis using solid-phase microextraction (SPME) technology in environmental, food, and bio-clinical analysis. The covered papers were published in the last 5 years (2014–2019) thus providing the reader with information about the current state-of-the-art and the future potential directions of the research in pollutant monitoring using SPME. To this end, we revised the studies focused on the investigation of persistent organic pollutants (POPs), pesticides, and emerging pollutants (EPs) including personal care products (PPCPs), in different environmental, food, and bio-clinical matrices. We especially emphasized the role that SPME is having in contaminant surveys following the path that goes from the environment to humans passing through the food web. Besides, this review covers the last technological developments encompassing the use of novel extraction coatings (e.g., metal-organic frameworks, covalent organic frameworks, PDMS-overcoated fiber), geometries (e.g., Arrow-SPME, multiple monolithic fiber-SPME), approaches (e.g., vacuum and cold fiber SPME), and on-site devices. The applications of SPME hyphenated with ambient mass spectrometry have also been described.

Metal-organic frameworks as catalysts for sugar conversion into platform chemicals: State-of-the-art and prospects

2019 ◽  
Vol 401 ◽  
pp. 213064 ◽  
Author(s):  
Noor Aljammal ◽  
Christia Jabbour ◽  
Joris W. Thybaut ◽  
Kristof Demeestere ◽  
Francis Verpoort ◽  
...  
Keyword(s):  
State Of The Art ◽  
Metal Organic Frameworks ◽  
Platform Chemicals ◽  
Metal Organic ◽  
Sugar Conversion

Hybridization of metal–organic frameworks and task-specific ionic liquids: fundamentals and challenges

2018 ◽  
Vol 2 (2) ◽  
pp. 219-234 ◽  
Author(s):  
Qun-xing Luo ◽  
Bo-wen An ◽  
Min Ji ◽  
Jie Zhang
Keyword(s):  
Ionic Liquids ◽  
Critical Review ◽  
State Of The Art ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
And Task

This critical review presents the fundamentals, challenges, and outlooks in MTHMs according to state-of-the-art progress and first-hand experience.

Green synthesis of metal–organic frameworks: A state-of-the-art review of potential environmental and medical applications

2020 ◽  
Vol 420 ◽  
pp. 213407 ◽  
Author(s):  
Sandeep Kumar ◽  
Shikha Jain ◽  
Monika Nehra ◽  
Neeraj Dilbaghi ◽  
Giovanna Marrazza ◽  
...  
Keyword(s):  
Green Synthesis ◽  
State Of The Art ◽  
Metal Organic Frameworks ◽  
Medical Applications ◽  
Metal Organic

scholarly journals Metal–Organic Frameworks as Key Materials for Solid-Phase Microextraction Devices—A Review

Separations ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 47 ◽  
Author(s):  
Gutiérrez-Serpa ◽  
Pacheco-Fernández ◽  
Pasán ◽  
Pino
Keyword(s):  
Metal Ion ◽  
Solid Phase Microextraction ◽  
Metal Clusters ◽  
Solid Phase ◽  
Metal Organic Frameworks ◽  
High Chemical ◽  
Current State ◽  
Metal Organic ◽  
Sorbent Materials ◽  
Ordered Porous

Metal–organic frameworks (MOFs) have attracted recently considerable attention in analytical sample preparation, particularly when used as novel sorbent materials in solid-phase microextraction (SPME). MOFs are highly ordered porous crystalline structures, full of cavities. They are formed by inorganic centers (metal ion atoms or metal clusters) and organic linkers connected by covalent coordination bonds. Depending on the ratio of such precursors and the synthetic conditions, the characteristics of the resulting MOF vary significantly, thus drifting into a countless number of interesting materials with unique properties. Among astonishing features of MOFs, their high chemical and thermal stability, easy tuneability, simple synthesis, and impressive surface area (which is the highest known), are the most attractive characteristics that makes them outstanding materials in SPME. This review offers an overview on the current state of the use of MOFs in different SPME configurations, in all cases covering extraction devices coated with (or incorporating) MOFs, with particular emphases in their preparation.

Novel metal–organic framework materials: blends, liquids, glasses and crystal–glass composites

2019 ◽  
Vol 55 (60) ◽  
pp. 8705-8715 ◽  
Author(s):  
Joshua M. Tuffnell ◽  
Christopher W. Ashling ◽  
Jingwei Hou ◽  
Shichun Li ◽  
Louis Longley ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Crystal Glass ◽  
Zeolitic Imidazolate Framework ◽  
Feature Article ◽  
Glass Composites ◽  
Framework Materials ◽  
Recent Advances ◽  
Metal Organic ◽  
Organic Framework

This Feature Article reviews a range of amorphisation mechanisms of Metal–Organic Frameworks (MOFs) and presents recent advances to produce novel MOF materials including porous MOF glasses, MOF crystal–glass composites, flux melted MOF glasses and blended zeolitic imidazolate framework glasses.

scholarly journals A novel zinc sulfide impregnated carbon composite derived from zeolitic imidazolate framework-8 for sodium-ion hybrid solid-state flexible capacitors

2021 ◽  
Author(s):  
Vishal Shrivastav ◽  
Shashank Sundriyal ◽  
Priyanshu Goel ◽  
Avishek Saha ◽  
Umesh K. Tiwari ◽  
...  
Keyword(s):  
Solid State ◽  
Specific Surface ◽  
Metal Oxides ◽  
Zinc Sulfide ◽  
Metal Organic Frameworks ◽  
Carbon Composite ◽  
High Specific Surface Area ◽  
Sodium Ion ◽  
Zeolitic Imidazolate Framework ◽  
Metal Organic

The pyrolysis of metal–organic frameworks (MOFs) is an easy approach to prepare metal oxides as well as nanoporous carbon with high specific surface area.

Metal-organic frameworks for catalysis: State of the art, challenges, and opportunities

EnergyChem ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 100005 ◽  
Author(s):  
Dandan Li ◽  
Hai-Qun Xu ◽  
Long Jiao ◽  
Hai-Long Jiang
Keyword(s):  
State Of The Art ◽  
Metal Organic Frameworks ◽  
Challenges And Opportunities ◽  
Metal Organic
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