Metal–organic frameworks as scaffolds for the encapsulation of active species: state of the art and future perspectives

2012 ◽  
Vol 22 (20) ◽  
pp. 10102 ◽  
Author(s):  
Jana Juan-Alcañiz ◽  
Jorge Gascon ◽  
Freek Kapteijn
2018 ◽  
Vol 17 (7) ◽  
pp. 864-873 ◽  
Author(s):  
H. A. Schwartz ◽  
U. Ruschewitz ◽  
L. Heinke

The opportunities, properties and perspectives of smart photochromic materials, which are obtained by embedment of stimuli-responsive molecules in nanoporous MOFs (metal–organic frameworks), both in bulk and in thin films, are reviewed.


Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 137
Author(s):  
Chun-Yan Shih ◽  
Pei-Ting Wang ◽  
Wu-Chou Su ◽  
Hsisheng Teng ◽  
Wei-Lun Huang

Since the first clinical cancer treatment in 1978, photodynamic therapy (PDT) technologies have been largely improved and approved for clinical usage in various cancers. Due to the oxygen-dependent nature, the application of PDT is still limited by hypoxia in tumor tissues. Thus, the development of effective strategies for manipulating hypoxia and improving the effectiveness of PDT is one of the most important area in PDT field. Recently, emerging nanotechnology has benefitted progress in many areas, including PDT. In this review, after briefly introducing the mechanisms of PDT and hypoxia, as well as basic knowledge about nanomedicines, we will discuss the state of the art of nanomedicine-based approaches for assisting PDT for treating hypoxic tumors, mainly based on oxygen replenishing strategies and the oxygen dependency diminishing strategies. Among these strategies, we will emphasize emerging trends about the use of nanoscale metal–organic framework (nMOF) materials and the combination of PDT with immunotherapy. We further discuss future perspectives and challenges associated with these trends in both the aspects of mechanism and clinical translation.


2019 ◽  
Vol 401 ◽  
pp. 213064 ◽  
Author(s):  
Noor Aljammal ◽  
Christia Jabbour ◽  
Joris W. Thybaut ◽  
Kristof Demeestere ◽  
Francis Verpoort ◽  
...  

2018 ◽  
Vol 2 (2) ◽  
pp. 219-234 ◽  
Author(s):  
Qun-xing Luo ◽  
Bo-wen An ◽  
Min Ji ◽  
Jie Zhang

This critical review presents the fundamentals, challenges, and outlooks in MTHMs according to state-of-the-art progress and first-hand experience.


2020 ◽  
Vol 420 ◽  
pp. 213407 ◽  
Author(s):  
Sandeep Kumar ◽  
Shikha Jain ◽  
Monika Nehra ◽  
Neeraj Dilbaghi ◽  
Giovanna Marrazza ◽  
...  

EnergyChem ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 100005 ◽  
Author(s):  
Dandan Li ◽  
Hai-Qun Xu ◽  
Long Jiao ◽  
Hai-Long Jiang

2020 ◽  
Vol 27 (35) ◽  
pp. 5949-5969 ◽  
Author(s):  
Jian Cao ◽  
Xuejiao Li ◽  
Hongqi Tian

Background: Developing a controllable drug delivery system is imperative and important to reduce side effects and enhance the therapeutic efficacy of drugs. Metal-organic frameworks (MOFs) an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers have attracted increasing attention in the recent years owing to the unique physical structures possessed, and the potential for vast applications. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, have made them promising candidates as drug delivery hosts. MOFs for drug delivery is of great interest and many very promising results have been found, indicating that these porous solids exhibit several advantages over existing systems. Objective: This review highlights the latest advances in the synthesis, functionalization, and applications of MOFs in drug delivery, and has classified them using drug loading strategies. Finally, challenges and future perspectives in this research area are also outlined.


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