scholarly journals Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

2020 ◽  
Author(s):  
wei zhu ◽  
Miaomiao Kang ◽  
qian wu ◽  
Zhijun Zhang ◽  
yi wu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Molecular Design ◽  
Infrared Region ◽  
High Fidelity ◽  
Facile Synthesis ◽  
Rational Molecular Design ◽  
Near Infrared Region ◽  
Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

2020 ◽  
Author(s):  
wei zhu ◽  
Miaomiao Kang ◽  
qian wu ◽  
Zhijun Zhang ◽  
yi wu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Molecular Design ◽  
Infrared Region ◽  
High Fidelity ◽  
Facile Synthesis ◽  
Rational Molecular Design ◽  
Near Infrared Region ◽  
Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

scholarly journals Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

2020 ◽  
Author(s):  
wei zhu ◽  
Miaomiao Kang ◽  
qian wu ◽  
Zhijun Zhang ◽  
yi wu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Molecular Design ◽  
Infrared Region ◽  
High Fidelity ◽  
Facile Synthesis ◽  
Rational Molecular Design ◽  
Near Infrared Region ◽  
Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

scholarly journals Facile synthesis of β-lactoglobulin capped Ag2S quantum dots for in vivo imaging in the second near-infrared biological window

2016 ◽  
Vol 4 (37) ◽  
pp. 6271-6278 ◽  
Author(s):  
Jun Chen ◽  
Yifei Kong ◽  
Yan Wo ◽  
Hongwei Fang ◽  
Yunxia Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
Facile Synthesis ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots ◽  
Β Lactoglobulin

Effectivein vivofluorescence imaging based on β-LG-Ag2S quantum dots at the second near-infrared region.

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

2012 ◽  
Vol 51 (39) ◽  
pp. 9818-9821 ◽  
Author(s):  
Guosong Hong ◽  
Joshua T. Robinson ◽  
Yejun Zhang ◽  
Shuo Diao ◽  
Alexander L. Antaris ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

2012 ◽  
Vol 124 (39) ◽  
pp. 9956-9959 ◽  
Author(s):  
Guosong Hong ◽  
Joshua T. Robinson ◽  
Yejun Zhang ◽  
Shuo Diao ◽  
Alexander L. Antaris ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots

scholarly journals Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Yingying Chen ◽  
Liru Xue ◽  
Qingqing Zhu ◽  
Yanzhi Feng ◽  
Mingfu Wu
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
High Sensitivity ◽  
Infrared Region ◽  
Radiation Hazard ◽  
High Signal ◽  
Tissue Penetration ◽  
Tumor Delineation ◽  
Near Infrared Region

Fluorescence imaging technique, characterized by high sensitivity, non-invasiveness and no radiation hazard, has been widely applicated in the biomedical field. However, the depth of tissue penetration is limited in the traditional (400–700 nm) and NIR-I (the first near-infrared region, 700–900 nm) imaging, which urges researchers to explore novel bioimaging modalities with high imaging performance. Prominent progress in the second near-infrared region (NIR-II, 1000–1700 nm) has greatly promoted the development of biomedical imaging. The NIR-II fluorescence imaging significantly overcomes the strong tissue absorption, auto-fluorescence as well as photon scattering, and has deep tissue penetration, micron-level spatial resolution, and high signal-to-background ratio. NIR-II bioimaging has been regarded as the most promising in vivo fluorescence imaging technology. High brightness and biocompatible fluorescent probes are crucial important for NIR-II in vivo imaging. Herein, we focus on the recently developed NIR-II fluorescent cores and their applications in the field of biomedicine, especially in tumor delineation and image-guided surgery, vascular imaging, NIR-II-based photothermal therapy and photodynamic therapy, drug delivery. Besides, the challenges and potential future developments of NIR-II fluorescence imaging are further discussed. It is expected that our review will lay a foundation for clinical translation of NIR-II biological imaging, and inspire new ideas and more researches in this field.

scholarly journals Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation

2021 ◽  
Vol 9 ◽  
Author(s):  
Songjiao Li ◽  
Dan Cheng ◽  
Longwei He ◽  
Lin Yuan
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Surgical Navigation ◽  
Infrared Region ◽  
Treatment Technology ◽  
Disease Treatment ◽  
Guided Surgery ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Near Infrared Region

Cancer is still one of the main causes of morbidity and death rate around the world, although diagnostic and therapeutic technologies are used to advance human disease treatment. Currently, surgical resection of solid tumors is the most effective and a prior remedial measure to treat cancer. Although medical treatment, technology, and science have advanced significantly, it is challenging to completely treat this lethal disease. Near-infrared (NIR) fluorescence, including the first near-infrared region (NIR-I, 650–900 nm) and the second near-infrared region (NIR-II, 1,000–1,700 nm), plays an important role in image-guided cancer surgeries due to its inherent advantages, such as great tissue penetration, minimal tissue absorption and emission light scattering, and low autofluorescence. By virtue of its high precision in identifying tumor tissue margins, there are growing number of NIR fluorescence-guided surgeries for various living animal models as well as patients in clinical therapy. Herein, this review introduces the basic construction and operation principles of fluorescence molecular imaging technology, and the representative application of NIR-I/II image-guided surgery in biomedical research studies are summarized. Ultimately, we discuss the present challenges and future perspectives in the field of fluorescence imaging for surgical navigation and also put forward our opinions on how to improve the efficiency of the surgical treatment.

scholarly journals Deep-Red and Near-Infrared Iridium Complexes with Fine-Tuned Emission Colors by Adjusting Trifluoromethyl Substitution on Cyclometalated Ligands Combined with Matched Ancillary Ligands for Highly Efficient Phosphorescent Organic Light-Emitting Diodes

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 286
Author(s):  
Shuonan Chen ◽  
Hai Bi ◽  
Wenjing Tian ◽  
Yu Liu
Keyword(s):  
Near Infrared ◽  
Light Emitting Diodes ◽  
Molecular Design ◽  
Infrared Region ◽  
Organic Light Emitting Diodes ◽  
Iridium Complexes ◽  
Light Emitting ◽  
Practical Applications ◽  
Organic Light ◽  
Near Infrared Region

Six novel Ir(C^N)2(L^X)-type heteroleptic iridium complexes with deep-red and near-infrared region (NIR)-emitting coverage were constructed through the cross matching of various cyclometalating (C^N) and ancillary (LX) ligands. Here, three novel C^N ligands were designed by introducing the electron-withdrawing group CF3 on the ortho (o-), meta (m-), and para (p-) positions of the phenyl ring in the 1-phenylisoquinoline (piq) group, which were combined with two electron-rich LX ligands (dipba and dipg), respectively, leading to subsequent iridium complexes with gradually changing emission colors from deep red (≈660 nm) to NIR (≈700 nm). Moreover, a series of phosphorescent organic light-emitting diodes (PhOLEDs) were fabricated by employing these phosphors as dopant emitters with two doping concentrations, 5% and 10%, respectively. They exhibited efficient electroluminescence (EL) with significantly high EQE values: >15.0% for deep red light0 (λmax = 664 nm) and >4.0% for NIR cases (λmax = 704 nm) at a high luminance level of 100 cd m−2. This work not only provides a promising approach for finely tuning the emission color of red phosphors via the easily accessible molecular design strategy, but also enables the establishment of an effective method for enriching phosphorescent-emitting molecules for practical applications, especially in the deep-red and near-infrared region (NIR).

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