scholarly journals Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation

2021 ◽  
Vol 9 ◽  
Author(s):  
Songjiao Li ◽  
Dan Cheng ◽  
Longwei He ◽  
Lin Yuan
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Surgical Navigation ◽  
Infrared Region ◽  
Treatment Technology ◽  
Disease Treatment ◽  
Guided Surgery ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Near Infrared Region

Cancer is still one of the main causes of morbidity and death rate around the world, although diagnostic and therapeutic technologies are used to advance human disease treatment. Currently, surgical resection of solid tumors is the most effective and a prior remedial measure to treat cancer. Although medical treatment, technology, and science have advanced significantly, it is challenging to completely treat this lethal disease. Near-infrared (NIR) fluorescence, including the first near-infrared region (NIR-I, 650–900 nm) and the second near-infrared region (NIR-II, 1,000–1,700 nm), plays an important role in image-guided cancer surgeries due to its inherent advantages, such as great tissue penetration, minimal tissue absorption and emission light scattering, and low autofluorescence. By virtue of its high precision in identifying tumor tissue margins, there are growing number of NIR fluorescence-guided surgeries for various living animal models as well as patients in clinical therapy. Herein, this review introduces the basic construction and operation principles of fluorescence molecular imaging technology, and the representative application of NIR-I/II image-guided surgery in biomedical research studies are summarized. Ultimately, we discuss the present challenges and future perspectives in the field of fluorescence imaging for surgical navigation and also put forward our opinions on how to improve the efficiency of the surgical treatment.

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

2012 ◽  
Vol 51 (39) ◽  
pp. 9818-9821 ◽  
Author(s):  
Guosong Hong ◽  
Joshua T. Robinson ◽  
Yejun Zhang ◽  
Shuo Diao ◽  
Alexander L. Antaris ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots

Image-guided near-infrared fluorescent sentinel lymph node mapping in human breast cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11591-e11591
Author(s):  
S. Troyan ◽  
S. Gibbs-Strauss ◽  
S. Gioux ◽  
R. Oketokoun ◽  
F. Azar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Optical Imaging ◽  
Real Time ◽  
Near Infrared ◽  
Imaging System ◽  
Sulfur Colloid ◽  
Guided Surgery ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Surgical Field

e11591 Background: Breast cancer surgery is presently performed without real-time image-guidance. We have developed a novel optical imaging system for image-guided surgery that uses invisible near-infrared (NIR) fluorescent light to highlight structures on the surgical field with high sensitivity, specificity, and contrast. We have also performed the first human clinical trial of the imaging system in women undergoing SLN mapping for breast cancer. Methods: We used a portable imaging system with an articulating arm that has 6 degrees of freedom, high power LED light source, custom optics, custom software, and sterile drape. The imaging system provided simultaneous and real-time imaging of color video and NIR fluorescence at up to 15 frames per second. N = 6 women with biopsy- confirmed breast cancer undergoing SLN mapping gave informed consent. All subjects received conventional mapping with Tc-99m sulfur colloid using a handheld gamma probe as well as NIR fluorescence-guided SLN mapping using a mixture of indocyanine green (ICG) diluted to a final concentration of 10 μM in human serum albumin (ICG:HSA). Results: The imaging system was easy to position in the operating room, with the articulating arm providing 50” horizontal reach and 70” vertical reach. Working distance to the patient was 18”. NIR fluorescence excitation was 20 mW/cm2 at 760 nm. NIR-depleted white light was 40,000 lux. A total of 1.6 ml of ICG:HSA was injected intra-tumorally and peri-tumorally and the site massaged for 5 min. 8 of 9 SLNs identified by Tc- 99m sulfur colloid were also identified by NIR fluorescence. However, NIR fluorescence identified an SLN, confirmed to have cancer in it, that was not identified by Tc-99m sulfur colloid. These differences were consistent with asynchrony in the injection techniques. Unlike the gamma-ray probe, NIR fluorescence provided high-resolution, large area optical imaging of the surgical field, and helped guide surgical resection. Conclusions: In this 6-patient pilot study, a novel NIR fluorescence optical imaging system was used for the first time, and provided real-time image-guided surgery for SLN mapping of breast cancer. No significant financial relationships to disclose.

Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

2020 ◽  
Author(s):  
wei zhu ◽  
Miaomiao Kang ◽  
qian wu ◽  
Zhijun Zhang ◽  
yi wu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Molecular Design ◽  
Infrared Region ◽  
High Fidelity ◽  
Facile Synthesis ◽  
Rational Molecular Design ◽  
Near Infrared Region ◽  
Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

scholarly journals Facile synthesis of β-lactoglobulin capped Ag2S quantum dots for in vivo imaging in the second near-infrared biological window

2016 ◽  
Vol 4 (37) ◽  
pp. 6271-6278 ◽  
Author(s):  
Jun Chen ◽  
Yifei Kong ◽  
Yan Wo ◽  
Hongwei Fang ◽  
Yunxia Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
Facile Synthesis ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots ◽  
Β Lactoglobulin

Effectivein vivofluorescence imaging based on β-LG-Ag2S quantum dots at the second near-infrared region.

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

2012 ◽  
Vol 124 (39) ◽  
pp. 9956-9959 ◽  
Author(s):  
Guosong Hong ◽  
Joshua T. Robinson ◽  
Yejun Zhang ◽  
Shuo Diao ◽  
Alexander L. Antaris ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots

scholarly journals Zwitterionic AIEgens: Rational Molecular Design for NIR-II Fluorescence Imaging-Guided Synergistic Phototherapy

2020 ◽  
Author(s):  
wei zhu ◽  
Miaomiao Kang ◽  
qian wu ◽  
Zhijun Zhang ◽  
yi wu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Rational Design ◽  
Near Infrared ◽  
Molecular Design ◽  
Infrared Region ◽  
High Fidelity ◽  
Facile Synthesis ◽  
Rational Molecular Design ◽  
Near Infrared Region ◽  
Synthesis Protocol

Fluorescence imaging in the second near-infrared region (NIR-II) can penetrate tissue at centimeter depths and obtain high fidelity of images. However, facile synthesis of small-molecule fluorescent photosensitizers for efficient NIR-II fluorescence imaging as well as photodynamic and photothermal combinatorial therapies (PDT-PTT) is still a challenging task. Herein, we reported a rational design and facile synthesis protocol for a series of novel NIR-emissive zwitterionic luminogens with aggregation-induced emission (AIE) features for cancer phototheranostics.

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