scholarly journals Prognostic relevance of the TNM classification 8th edition and new criteria of staging for retroperitoneal liposarcoma

2020 ◽  
Vol 22 (3) ◽  
pp. 120-126
Author(s):  
S. N. Nered ◽  
A. Yu. Volkov ◽  
N. А. Kozlov ◽  
I. S. Stilidi ◽  
P. P. Archery
Keyword(s):  
Survival Rate ◽  
Tnm Classification ◽  
Prognostic Significance ◽  
Retroperitoneal Tumors ◽  
Degree Of Malignancy ◽  
Eighth Edition ◽  
Retroperitoneal Sarcomas ◽  
First Time ◽  
8Th Edition ◽  
T Category

For the first time a section appeared for staging of non-organ retroperitoneal tumors in the UICC TNM classification 8th edition. Aim.To assess the prognostic significance of the TNM classification eighth edition for the most common retroperitoneal tumors-liposarcoma. Materials and methods.The distribution of patients by stages and survival in accordance with the TNM-8 classification were studied in192 patients with retroperitoneal non-organ liposarcoma (RLPS). Results.In the TNM-8 classification, only the degree of malignancy of the tumor has a prognostic value, and the T-category does not reflect the actual size of the RLPS and is considered T4 in 93%, which leads to inadequate staging. During the 15-year period, there were no cases with stages II and IIIA, and the survival rate was estimated only in patients with stages I and IIIB. A TNM classification with new values of the T-category was proposed, which demonstrated a more adequate distribution of patients by stages and the reliability ofintergroup differences in the survival rate. Conclusion.It is advisable to create a special TNM classification for RLPS, which makes up more than half of all retroperitoneal sarcomas.

scholarly journals Prognostic significance of the 8th edition of the TNM classification for patients with extensive disease small cell lung cancer

2018 ◽  
Vol Volume 10 ◽  
pp. 6039-6047 ◽  
Author(s):  
Masayuki Shirasawa ◽  
Tomoya Fukui ◽  
Seiichiro Kusuhara ◽  
Yasuhiro Hiyoshi ◽  
Mikiko Ishihara ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tnm Classification ◽  
Prognostic Significance ◽  
Small Cell ◽  
Small Cell Lung ◽  
Extensive Disease ◽  
8Th Edition

scholarly journals The Effect of Tegafur-Uracil on Survival in T Categories as Defined in the Eighth Edition of the TNM Classification: An Exploratory Analysis of Postoperative Adjuvant Tegafur-Uracil on Survival in Patients with Adenocarcinoma of the Lung

Chemotherapy ◽  
2017 ◽  
Vol 62 (6) ◽  
pp. 357-360
Author(s):  
Masahiro Tsuboi ◽  
Chikuma Hamada ◽  
Harubumi Kato ◽  
Mitsuo Ohta
Keyword(s):  
Tnm Classification ◽  
Tumor Diameter ◽  
Proportional Hazard ◽  
Adenocarcinoma Of The Lung ◽  
Proportional Hazard Models ◽  
Cox Proportional Hazard ◽  
Hazard Ratios ◽  
Cox Proportional Hazard Models ◽  
Eighth Edition ◽  
T Category

Background: Tegafur-uracil (UFT) improves survival in patients with stage I adenocarcinoma of the lung. We evaluated the effect of UFT on survival in maximum primary tumor diameter (T) categories as defined in the eighth edition of the TNM Classification (TNM8). Methods: Tumors were subgrouped on the basis of T category (TNM8) as follows: T1a, T ≤1 cm; T1b, 1 < T ≤2 cm; T1c, 2 < T ≤3 cm; T2a, 3 < T ≤4 cm; T2b , 4 < T ≤5 cm; T3, 5 < T ≤7 cm. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazard models. Results: UFT was associated with improved survival. The adjusted HRs were as follows: for T1a, 0.79 (95% CI 0.14-4.50); for T1b, 1.16 (95% CI 0.63-2.12); for T1c, 0.74 (95% CI 0.43-1.27); for T2a, 0.45 (95% CI 0.21-0.96); for T2b, 0.55 (95% CI 0.10-3.07), and for T3, 0.70 (95% CI 0.20-2.50). Conclusions: The adjuvant chemotherapy with UFT tended to improve survival in patients with adenocarcinoma of the lung of each T category based on TNM8, except T1b.

scholarly journals Imaging and T Category for Prostate Cancer in the 8th Edition of the Union for International Cancer Control TNM Classification

2020 ◽  
Vol 3 (5) ◽  
pp. 563-564 ◽  
Author(s):  
Henk van der Poel ◽  
Theo van der Kwast ◽  
Katja Aben ◽  
Nicolas Mottet ◽  
Malcolm Mason
Keyword(s):  
Prostate Cancer ◽  
Tnm Classification ◽  
Cancer Control ◽  
8Th Edition ◽  
T Category

scholarly journals Carcinoma of Unknown Primary and the 8th Edition TNM Classification for Head and Neck Cancer

2021 ◽  
Author(s):  
Robert Boeker ◽  
Carmen Stromberger ◽  
Max Heiland ◽  
Benedicta Beck‐Broichsitter ◽  
Veit M. Hofmann ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tnm Classification ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
8Th Edition

Comments on the eighth edition of the TNM classification for lung cancer. Radical changes and limitations: Does size matter?

2017 ◽  
Vol 89 (3-4) ◽  
pp. 141-148 ◽  
Author(s):  
S. Nikolouzos ◽  
G. Zacharia ◽  
N. Baltayiannis ◽  
D. Anagnostopoulos ◽  
N. Bolanos ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tnm Classification ◽  
Eighth Edition ◽  
Size Matter

Prognostic impact of β-2-microglobulin expression in colorectal cancers stratified by mismatch repair status

2012 ◽  
Vol 65 (11) ◽  
pp. 996-1002 ◽  
Author(s):  
Viktor Hendrik Koelzer ◽  
Kristi Baker ◽  
Daniela Kassahn ◽  
Daniel Baumhoer ◽  
Inti Zlobec
Keyword(s):  
Protein Expression ◽  
Mismatch Repair ◽  
Immune Cell ◽  
Prognostic Significance ◽  
Clinicopathological Features ◽  
Prognostic Impact ◽  
Mismatch Repair Status ◽  
First Time ◽  
Intra Class Correlation Coefficient

Backgroundβ-2-microglobulin (B2M) is essential for antigen presentation, yet may also possess proto-oncogenic properties.AimTo determine the prognostic impact of B2M in patients with mismatch repair (MMR) proficient and deficient colorectal cancer (CRC) and to investigate whether this effect on outcome is dependent on the local immune response. MethodsB2M protein expression and tumour-infiltrating immune cells (CD3, CD16, CD163, CD20, CD4, CD45RO, CD56, CD68, CD8, FoxP3, GranzymeB, iNOS, mast cell tryptase, MUM1, PD1, TIA-1) were evaluated in a well characterised tissue microarray of 408 CRCs. The predictive value for clinicopathological features and the prognostic significance of B2M expression were analysed, stratified by MMR status and the immunohistological characteristics of immune cell infiltrates. ResultsInterobserver agreement for B2M staining was high (intra-class correlation coefficient=0.91). Complete B2M loss was more frequent in MMR-deficient (19.4%) compared to MMR-proficient (7.1%) tumours (p<0.001). In MMR-deficient cases, B2M loss predicted rare local recurrence (p=0.034), infrequent nodal-positivity (p=0.035), absence of distant metastasis (p=0.048; sensitivity=100%) and a trend towards favourable survival (p=0.124) independent of immune infiltrates. No associations between B2M and clinicopathological features were observed in MMR-proficient cases.ConclusionsOur data show for the first time that absence of B2M protein expression identifies MMR-deficient cancers with a favourable clinical course and absence of metastatic disease. Validation of B2M protein expression for sub-classification of MMR-deficient CRC is recommended for future clinical trials.

Indeterminate Chagas’ disease: Trypanosoma cruzi strain and re-infection are factors involved in the progression of cardiopathy

2003 ◽  
Vol 104 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Juan M. BUSTAMANTE ◽  
Héctor W. RIVAROLA ◽  
Alicia R. FERNÁNDEZ ◽  
Julio E. ENDERS ◽  
Ricardo FRETES ◽  
...  
Keyword(s):  
Survival Rate ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Infected Group ◽  
World Health ◽  
Cardiac Lesions ◽  
Health Organization ◽  
Host Parasite ◽  
Β Adrenergic Receptors ◽  
First Time

Chagas' disease is caused by Trypanosoma cruzi, which is transmitted by reduviid bugs. The World Health Organization has estimated that about 16–18 million people in the Americas are infected, and that more than 100 million are at risk. In the present study we have used a murine model to analyse if particular T. cruzi strains (Tulahuen strain and SGO-Z12 isolate from a chronic patient) and/or re-infection may determine, during the indeterminate phase of experimental Chagas' disease, changes that could explain the different evolution of cardiac lesions. Re-infected mice reached higher parasitaemias than those infected for the first time. The survival in the indeterminate phase of mice infected with Tulahuen strain was 50.0%, while the SGO-Z12-infected group presented a significantly higher survival rate (77.1%; P<0.01). The SGO-Z12-re-infected group showed a survival rate (70.9%) significantly higher than that of the Tulahuen-re-infected group (37.0%; P<0.01). Electrocardiographic abnormalities were found in 66% of Tulahuen-infected mice, while in SGO-Z12-infected group such abnormalities were found in only 36% of animals (P<0.01). The two groups exhibited similar percentages of electrocardiographic dysfunction on re-infection, although intraventricular blocks were more frequent in Tulahuen-re-infected mice (P<0.01). Hearts from infected or re-infected mice with either parasite showed mononuclear infiltrates. The SGO-Z12-re-infected and Tulahuen-re-infected groups exhibited a significantly diminished affinity (P<0.05) and a significantly increased density (P<0.05) of cardiac β-adrenergic receptors compared with the infected and non-infected groups. The indeterminate phase of Chagas' disease is defined as a prolonged period that is clinically silent, but the present findings show that different T. cruzi strains and re-infection are able to alter the host–parasite equilibrium, and these factors may be responsible for inducing progressive cardiopathy.

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