Vulvovaginitis of mixed etiology and real clinical practice

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (4) ◽  
pp. 82-87
Author(s):  
Vera N. Prilepskaya ◽  
Patimat R. Abakarova ◽  
Andrei E. Donnikov
Keyword(s):  
Genital Tract ◽  
Inflammatory Diseases ◽  
Mixed Infections ◽  
Pathogenic Microorganisms ◽  
Ascending Infection ◽  
Lower Genital Tract ◽  
Wide Range ◽  
Frequent Relapses ◽  
The One ◽  
Combined Drugs

Lower genital tract inflammatory diseases, caused by opportunistic and pathogenic microorganisms (vulvovaginitis), occupy a leading place among gynecological diseases and are one of the most common reasons for women to consult an obstetrician-gynecologist. Vulvovaginitis is rarely caused by a single pathogen. In recent years, lower genital tract inflammatory diseases are characterized by the predominance of mixed infections, which, on the one hand, can lead to a more severe and prolonged course, frequent relapses, an ascending infection, and, on the other hand, can be asymptomatic, till the development of complications, and represent certain difficulties in the diagnosis and choice of therapy. Opportunistic pathogens and anaerobes-bacteroides play a major role in manifestations of mixed infections. Currently, in the treatment of mixed vulvovaginitis, preference is given to combined drugs that have an effect on a wide range of pathogenic microorganisms. One of them is Metromicon-Neo, which features of action and our experience of its use along with the features of mixed vulvovaginitis are summarized in the article.

Recurrent vulvovaginitis and vaginosis. Possibilities of effective therapy

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 76-80
Author(s):  
Vera N. Prilepskaya ◽  
Ada T. Uruimagova ◽  
Angelina A. Ivanova
Keyword(s):  
Mixed Infection ◽  
Genital Tract ◽  
Clinical Effect ◽  
Inflammatory Diseases ◽  
Effective Therapy ◽  
Pathogenic Microorganisms ◽  
Medical Institutions ◽  
Lower Genital Tract

Infectious and inflammatory diseases of the genitals caused by various opportunistic and pathogenic microorganisms arefound in 70% of all gynecological patients who seek help from medical institutions. Currently, scientists and clinicians in their practice are increasingly faced with insufficient effectiveness of treatment of vulvovaginitis and vaginosis, a tendency to a long and protracted course, recurrence of the process. One of the reasons for the longer and more severe course, the recurrence of the process is the increasingly common mixed infection with the possible simultaneous predominance of aerobes, anaerobes, andCandidafungi, which suggests the appointment of appropriate drugs. One of these drugs is Tergynan, which demonstrates a good clinical effect and tolerability of the drug in the treatment of recurrent vulvovaginitis and dysbiotic conditions of the lower genital tract.

scholarly journals Variants of uric acid metabolism and their immune and microbiota accompaniments in patients with neuroendocrine-immune complex dysfunction

2020 ◽  
Author(s):  
Vadym S. Smagliy ◽  
Anatoliy I. Gozhenko ◽  
I. Knyazeva ◽  
Nataliya S. Badiuk ◽  
Walery Zukow ◽  
...  
Keyword(s):  
Uric Acid ◽  
Immune Complex ◽  
Acid Metabolism ◽  
Inflammatory Diseases ◽  
Rehabilitation Treatment ◽  
Functional Relationships ◽  
Wide Range ◽  
Daily Urine ◽  
Z Scores ◽  
The One

Background. Previously, we found a wide range of uric acid exchange parameters and functional relationships of uricemia and uricosuria with the parameters of immunity in healthy rats analyzed. We continued our research along the same lines in the clinical observation of patients, who came to the Truskavets’ spa for the rehabilitation treatment. Relationships between uricemia and uricosuria, on the one hand, and immunity and microbiota parameters, on the other hand, have been identified. The purpose of this study is to further explore these relationships using the cluster and discriminant analyses. Material and Methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets’ spa for the rehabilitation treatment of chronic pyelonephritis combined with cholecystitis in remission. The serum and daily urine levels of the uric acid by uricase method were determined. Immune status evaluated on a set of I and II levels recommended by the WHO. The condition of microbiota is evaluated on the results of sowing of feces and urine. Results. Cluster analysis revealed 4 variants of uric acid metabolism by deviating uricosuria and uricemia from the norm in Z-scores. In 34% of individuals, moderate hypouricosuria (-0,97±0,11 Z) is combined with a lower borderline uricemia (-0,53±0,20 Z). In 25% of patients, lower-border uricemia (-0,70±0,22 Z) is accompanied by marked hyperuricosuria (+3,87±0,25 Z). In 24% of people, moderately elevated uricosuria (+1,26±0,14 Z) is combined with completely normal uricemia (+0,09±0,16 Z). Finally, in 17%, a similar level of uricosuria (+1,17±0,19 Z) is combined with marked hypouricemia (-1,89±0,14 Z). Discriminant analysis revealed 12 parameters of immunity and 5 parameters of microbiota, by which the clusters of uric acid metabolism are identified with 94,3 %% accuracy.Conclusion. Endogenous uric acid has a modulating overall beneficial effect on a number of immune and microbiota parameters in both healthy rats and people with neuroendocrine-immune complex dysfunction on background of chronic inflammatory diseases.

scholarly journals MAIN AGENTS OF OPPORTUNISTIC INFECTIONS OF GENITOURINARY TRACTS AND THEIR ANTIBIOTIC RESISTANCE

2017 ◽  
Vol 3 ◽  
pp. 18-25
Author(s):  
Gleb Bondarenko ◽  
Svetlana Dzhoraeva ◽  
Anna Kondakova ◽  
Iuliia Shcherbakova ◽  
Nataliya Sobol ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Opportunistic Infections ◽  
Inflammatory Diseases ◽  
Antibiotic Sensitivity ◽  
Genitourinary Tract ◽  
Pathogenic Microorganisms ◽  
Infectious Agents ◽  
The One ◽  
Taxonomic Groups

Today the one of most important medical-social problems is a growing antibiotic resistance of opportunistic infectious agents. Aim of research: the dynamic observance of antibiotic resistance of opportunistic pathogens – infectious agents of genitourinary tracts under conditions of venereological clinic. The study included 2205 patients with inflammatory diseases of genitourinary tract, who were on the stationary treatment at the department of venereology of SI “IDV NAMS of Ukraine”. Bacteriological studies for isolation of conventionally pathogenic microorganisms with determination of sensitivity of separated laboratory strains to antibacterial drugs of the different groups were carried out using the methods of classic bacteriology. It was demonstrated, that the composition of microbiocenosis of genitourinary tract in patients with infections, caused by conventionally pathogenic microorganisms was characterized by the prevalence of aerobic representatives of Enterobacteriaceae and Staphylococcaceae families that formed associations both between each other and with representatives of other taxonomic groups. The analysis of antibiotic sensitivity of separated strains testifies to the necessity of permanent microbiological monitoring of opportunistic infectious agents for elaborations of the regimes of rational antibacterial therapy.

Application of the preparation "Spiramycin-Vero" for treatment of inflammatory diseases of female genital organs

10.12737/3859 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-3
Author(s):  
Раннева ◽  
L. Ranneva ◽  
Хадарцева ◽  
K. Khadartseva
Keyword(s):  
Mixed Infection ◽  
Clinical Picture ◽  
Genital Tract ◽  
Inflammatory Diseases ◽  
Microscopy Study ◽  
Laboratory Examination ◽  
Lower Genital Tract ◽  
Clinical Diagnoses ◽  
Female Genital

The paper presents the results of clinical and laboratory examination of 60 women living in Tula city, who were examined by a gynecologist with microscopy study, PCR research and culture of the vagina on the flora and sensitivity to antibiotics. The control examination was after 1 and 3 months. Of the total surveyed, the 60 persons with inflammation of the lower genital tract, with identical clinical picture, Chlamydia, Mycoplasma, Ureaplasma, and mixed infection were selected. Clinical diagnoses were: at 53,3% - coleitis, 10% - cervicitis, 13,3% - vulvit, 23.3% - vulvovaginitis. The system preparation "Spiramycin-Vero" was prescribed to all patients. It was established its effectiveness at the vulvovaginitis and the effectiveness of this preparation in combination with intravaginal form of antibiotics.

scholarly journals Chlamydial Plasmid-Encoded Virulence Factor Pgp3 Neutralizes the Antichlamydial Activity of Human Cathelicidin LL-37

2015 ◽  
Vol 83 (12) ◽  
pp. 4701-4709 ◽  
Author(s):  
Shuping Hou ◽  
Xiaohua Dong ◽  
Zhangsheng Yang ◽  
Zhongyu Li ◽  
Quanzhong Liu ◽  
...  
Keyword(s):  
Genital Tract ◽  
Therapeutic Agents ◽  
Middle Region ◽  
Tubal Infertility ◽  
Significant Information ◽  
Content Type ◽  
Ascending Infection ◽  
Lower Genital Tract ◽  
Novel Therapeutic

Chlamydia trachomatisinfection in the lower genital tract can ascend to and cause pathologies in the upper genital tract, potentially leading to severe complications, such as tubal infertility. However, chlamydial organisms depleted of plasmid or deficient in the plasmid-encoded Pgp3 are attenuated in ascending infection and no longer are able to induce the upper genital tract pathologies, indicating a significant role of Pgp3 in chlamydial pathogenesis. We now report thatC. trachomatisPgp3 can neutralize the antichlamydial activity of human cathelicidin LL-37, a host antimicrobial peptide secreted by both genital tract epithelial cells and infiltrating neutrophils. Pgp3 bound to and formed stable complexes with LL-37. We further showed that the middle region of Pgp3 (Pgp3m) was responsible for both the binding to and neutralization of LL-37, suggesting that Pgp3m can be targeted for attenuating chlamydial pathogenicity or developed for blocking LL-37-involved non-genital-tract pathologies, such as rosacea and psoriasis. Thus, the current study has provided significant information for both understanding the mechanisms of chlamydial pathogenesis and developing novel therapeutic agents.

scholarly journals Vaginitis and cervicitis: choice of an effective therapy method (literature review)

2020 ◽  
pp. 17-23 ◽  
Author(s):  
N. M. Nazarova ◽  
M. E. Nekrasova ◽  
E. R. Dovletkhanova ◽  
P. R. Abakarova
Keyword(s):  
Genital Tract ◽  
Inflammatory Diseases ◽  
Significant Proportion ◽  
Reproductive Age ◽  
Cervix Uteri ◽  
Pathological State ◽  
Local Immunity ◽  
Vaginal Microflora ◽  
Lower Genital Tract ◽  
Metabolic Action

Among gynaecological diseases in women of reproductive age the leading place is occupied by inflammatory diseases of the lower part of the genital tract (70%), a significant proportion of which are inflammatory processes of the vagina and cervix uteri. In ⅔ of women, cervicitis is most often asymptomatic, so they do not seek medical treatment, and 65–77.6% have a transition to a chronic form. Thus, chronic cervicitis is diagnosed in almost one in three women who seek assistance from a gynaecologist due to leukorrhea, and there is no tendency for a decrease in frequency. The article presents an actual view on the problem of inflammatory diseases of the lower genital tract. The analysis of some researches devoted to the influence of local immunity and the state of vaginal microflora on the development of chronic inflammatory diseases is carried out. The results of proteomic researches of cervicovaginal fluid in early diagnostics of inflammatory diseases of the lower genital tract and the possibility of using cytokine biomarkers in clinical practice with the aim of prediction of pathological state and choice of further treatment tactics of the patient are presented. Efficiency of use of the combined medication on the basis of chlorhexidine and dexpantenol possessing pronounced antimicrobial, regenerating and metabolic action and applied in therapy of acute and chronic vaginitis; bacterial vaginosis; endo-, exocervicitis that is topical in therapy of inflammatory diseases of the lower genital tract is considered.

scholarly journals Treatment of the vaginal disbiotic disorders in pregnant women before delivery

2019 ◽  
pp. 64-69
Author(s):  
V. L. Tyutyunnik ◽  
A. A. Balushkina ◽  
A. A. Mikhailova ◽  
N. E. Kan
Keyword(s):  
Pregnant Women ◽  
Premature Birth ◽  
Genital Tract ◽  
Infectious Complications ◽  
Laboratory Research ◽  
Pathogenic Microorganisms ◽  
Vaginal Infection ◽  
Vaginal Infections ◽  
Lower Genital Tract

The urgency of the problem of vaginal infection is determined by its highest prevalence in the structure of obstetric-gynecological morbidity. Currently, the share of diseases of the lower genital tract associated with quantitative unbalance conditionally pathogenic microorganisms of bacterial and fungal origin vagina, which occur in 40-65% of pregnant women. Carried out a sufficient number of studies showing the role of vaginal microbiocenosis dysbiotic violations in the development of pathology of pregnancy, childbirth and postpartum infectious complications. It is known, that for vaginal infections and dysbiosis significantly more often increases the risk of chronic placental insufficiency, premature birth, low birth weight and postpartum endometritis, wound infection. In connection with the above, it is important to timely diagnose microflora disorders using clinical and laboratory research methods, followed by adequate etiotropic therapy. Timely and effective treatment of vaginal dysbiosis in pregnant women before delivery reduces the risk of postpartum infectious complications.

scholarly journals Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection

2015 ◽  
Vol 1 (6) ◽  
pp. e1400225 ◽  
Author(s):  
Claire Gendrin ◽  
Jay Vornhagen ◽  
Lisa Ngo ◽  
Christopher Whidbey ◽  
Erica Boldenow ◽  
...  
Keyword(s):  
Mast Cell ◽  
Preterm Birth ◽  
Genital Tract ◽  
Mast Cell Degranulation ◽  
Microbial Infection ◽  
Amniotic Cavity ◽  
Proinflammatory Mediators ◽  
Ascending Infection ◽  
Lower Genital Tract ◽  
Deficient Mice

Ascending infection of microbes from the lower genital tract into the amniotic cavity increases the risk of preterm birth, stillbirth, and newborn infections. Host defenses that are critical for preventing ascending microbial infection are not completely understood. Group BStreptococcus(GBS) are Gram-positive bacteria that frequently colonize the lower genital tract of healthy women but cause severe infections during pregnancy, leading to preterm birth, stillbirth, or early-onset newborn infections. We recently described that the GBS pigment is hemolytic, and increased pigment expression promotes GBS penetration of human placenta. Here, we show that the GBS hemolytic pigment/lipid toxin and hyperpigmented GBS strains induce mast cell degranulation, leading to the release of preformed and proinflammatory mediators. Mast cell–deficient mice exhibit enhanced bacterial burden, decreased neutrophil mobilization, and decreased immune responses during systemic GBS infection. In a vaginal colonization model, hyperpigmented GBS strains showed increased persistence in mast cell–deficient mice compared to mast cell–proficient mice. Consistent with these observations, fewer rectovaginal GBS isolates from women in their third trimester of pregnancy were hyperpigmented/hyperhemolytic. Our work represents the first example of a bacterial hemolytic lipid that induces mast cell degranulation and emphasizes the role of mast cells in limiting genital colonization by hyperpigmented GBS.

Staphylococcus sciuri: an unusual cause of pelvic inflammatory disease

2005 ◽  
Vol 16 (6) ◽  
pp. 452-453 ◽  
Author(s):  
S Stepanović ◽  
P Ježek ◽  
I Dakić ◽  
D Vuković ◽  
L Seifert
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Streptococcus Agalactiae ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Lower Genital Tract ◽  
One Year ◽  
The One ◽  
Low Rate ◽  
Female Genital

We present the case of polymicrobial pelvic inflammatory disease (PID) that involved Staphylococcus sciuri, S. epidermidis, and Streptococcus agalactiae. In order to determine the frequency of S. sciuri isolation from the female lower genital tract, 3415 vaginal samples were analysed during the one-year study period. S. sciuri was isolated from three (0.09%) samples. In all the three cases, S. sciuri was obtained in mixed culture from outpatients without symptoms of infection. While the origin of S. sciuri in the female genital tract remains to be elucidated, the present study showed that this bacterium may colonize vagina and, moreover, may be involved in the pathogenesis of an infection as serious as PID. The low rate of isolation we established, however, indicates infrequent and, most probably, transient colonization of the female genital tract by S. sciuri.

Sign in / Sign up

Export Citation Format

Share Document