scholarly journals Aldosterone synthase gene polymorphism in patients with hypertension combined ischemic heart disease with in various left ventricular mass

2014 ◽  
Vol 11 (1) ◽  
pp. 16-20
Author(s):  
D A Yahontov ◽  
D A Derisheva ◽  
L F Gulyaeva
Keyword(s):  
Coronary Artery Disease ◽  
Heart Disease ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Aldosterone Synthase ◽  
Ventricular Mass ◽  
Artery Disease ◽  
The Relationship

Study purpose - assessment of the relationship of levels of aldosterone and natriuretic peptide plasma aldosterone synthase gene polymorphism variants in patients with coronary heart disease (CHD) in combination with arterial hypertension (AH) at different left ventricular mass.Materials and methods. The study involved 63 male with hypertension and CHD; there were 32 men with signs of left ventricular hypertrophy (LVH) and 31 men with coronary artery disease with hypertension with a normal index of left ventricular mass. Evaluated the concentrations of aldosterone and plasma natriuretic peptide (NUP) in the relationship with characteristic of aldosterone synthase gene polymorphism.Results. It is established that the genotype CYP11В2 T/С of is associated with increased levels of aldosterone and signs of left ventricular hypertrophy. The level of LVC in the signs of LVH group was 2,1 fold higher than in patients without LVH. For patients with evidence of left ventricular hypertrophy is characterized by: the genotype of CYP11В2 T/C (62,5% of cases), the identification of the T allele (1,3 times more likely than patients without evidence of LVH) and more rarely than with normal index of left ventricular mass occurs variant CYP11В2 T/Т and more rarely prevalent allele C. Conclusion. In patients with coronary artery disease and hypertension, it is reasonable to implement in practice population genetic analysis to assess the probability the formation of left ventricular hypertrophy in the early stages of the disease.

scholarly journals The Relationship between Adiponectin and Left Ventricular Mass Index Varies with the Risk of Left Ventricular Hypertrophy

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70246 ◽  
Author(s):  
Yonggu Lee ◽  
Bae Keun Kim ◽  
Young-Hyo Lim ◽  
Mi Kyung Kim ◽  
Bo Youl Choi ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass ◽  
The Relationship

scholarly journals The Relationship Between Syndrome X and Left Ventricular Hypertrophy: The Impact Of Different Methods of Adjusting Left Ventricular Mass.

Circulation ◽  
2001 ◽  
Vol 103 (suppl_1) ◽  
pp. 1363-1364
Author(s):  
Heidi M Guyer ◽  
Manel Pladevall ◽  
Aina M Yanez ◽  
Carles Falces ◽  
Josep Sadurni ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Syndrome X ◽  
Adjustment Method ◽  
Ventricular Mass ◽  
The Impact ◽  
The Relationship

P67 Left ventricular hypertrophy is associated with the various elements of the insulin resistance syndrome (Syndrome X) including insulin resistance, hypertension, diabetes, dyslipidemia and obesity. There is no current consensus on the correct method of adjusting left ventricular mass (LVM). Objective: To determine the variation in the relationship between left ventricular hypertrophy (LVH)and Syndrome X when LVM is adjusted for height, height 2.7 and body surface area (BSA) in a population based study. Methods:LVM was measured echocardiographically in 442 participants aged 35 to 65 years. Results: The prevalence of LVH ranged from 15.6% to 33.9% depending on adjustment method. The correlation between LVH and Syndrome X components varied by adjustment criteria and by sex. In men, LVH was only correlated with blood pressure and obesity measurements. In women, LVH was correlated with all Syndrome X components except HDL cholesterol. Regardless of adjustment method, women with Syndrome X were more likely to have LVH than those without Syndrome X, although the magnitude of the relationship varied by LVM adjustment (LVM/height 2.7 : OR 16.6, 95% CI: 6.7 41.1; LVM/BSA: OR 5.8, 95% CI: 2.6-12.9). In men, the relationship between Syndrome X and LVH was significant when LVM was adjusted for height 2.7 (OR 3.0, 95% CI: 1.4-6.7) but not when adjusted for BSA (OR 1.2, 95% CI: 0.4-3.5). Conclusions:Both the prevalence of LVH and the relationship between LVH and Syndrome X are dependent on the method used to adjust LVM. When LVM is adjusted for height 2.7 , LVH is more prevalent and the relationship with Syndrome X is stronger than when adjusted for BSA. Regardless of adjustment method, the relationship between Syndrome X and LVH is much stronger in women than men. The LVM adjustment method employed is important to take into account both in epidemiological studies and clinical practice.

The association of ankle brachial index with left ventricular hypertrophy and left ventricular mass index: the Dong-gu study

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 284-291 ◽  
Author(s):  
Seong-Woo Choi ◽  
Hye-Yeon Kim ◽  
Hye-Ran Ahn ◽  
Young-Hoon Lee ◽  
Sun-Seog Kweon ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Left Ventricular ◽  
Baseline Survey ◽  
Ventricular Mass Index ◽  
Ventricular Mass

Background: To investigate the association between ankle-brachial index (ABI), left ventricular hypertrophy (LVH) and left ventricular mass index (LVMI) in a general population. Patients and methods: The study population consisted of 8,246 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2010. Trained research technicians measured LV mass using mode M ultrasound echocardiography and ABI using an oscillometric method. Results: After adjustment for risk factors and common carotid artery intima-media thickness (CCA-IMT) and the number of plaques, higher ABIs (1.10 1.19, 1.20 - 1.29, and ≥ 1.30) were significantly and linearly associated with high LVMI (1.10 - 1.19 ABI: β, 3.33; 95 % CI, 1.72 - 4.93; 1.20 - 1.29 ABI: β, 6.51; 95 % CI, 4.02 - 9.00; ≥ 1.30 ABI: β, 14.83; 95 % CI, 6.18 - 23.48). An ABI of 1.10 - 1.19 and 1.20 - 1.29 ABI was significantly associated with LVH (1.10 - 1.19 ABI: OR, 1.35; 95 % CI, 1.19 - 1.53; 1.20 - 1.29 ABI: OR, 1.59; 95 % CI, 1.31 - 1.92) and ABI ≥ 1.30 was marginally associated with LVH (OR, 1.73; 95 % CI, 0.93 - 3.22, p = 0.078). Conclusions: After adjustment for other cardiovascular variables and CCA-IMT and the number of plaques, higher ABIs are associated with LVH and LVMI in Koreans aged 50 years and older.

scholarly journals N-Terminal Pro-Brain Natriuretic Peptide and Right Ventricular Diameter Are Related to Aspirin Resistance in Coronary Artery Disease Patients

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 706
Author(s):  
Kamila Marika Cygulska ◽  
Łukasz Figiel ◽  
Dariusz Sławek ◽  
Małgorzata Wraga ◽  
Marek Dąbrowa ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Brain Natriuretic Peptide ◽  
Right Ventricular ◽  
Left Ventricular Mass ◽  
Natriuretic Peptide ◽  
Hemoglobin Concentration ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Artery Disease

Background and Objectives: Resistance to ASA (ASAres) is a multifactorial phenomenon defined as insufficient reduction of platelet reactivity through incomplete inhibition of thromboxane A2 synthesis. The aim is to reassess the prevalence and predictors of ASAres in a contemporary cohort of coronary artery disease (CAD) patients (pts) on stable therapy with ASA, 75 mg o.d. Materials and Methods: We studied 205 patients with stable CAD treated with daily dose of 75 mg ASA for a minimum of one month. ASAres was defined as ARU (aspirin reaction units) ≥550 using the point-of-care VerifyNow Aspirin test. Results: ASAres was detected in 11.7% of patients. Modest but significant correlations were detected between ARU and concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) (r = 0.144; p = 0.04), body weight, body mass index, red blood cell distribution width, left ventricular mass, and septal end-systolic thickness, with trends for left ventricular mass index and prothrombin time. In multivariate regression analysis, log(NT-proBNP) was identified as the only independent predictor of ARU—partial r = 0.15, p = 0.03. Median concentrations of NT-proBNP were significantly higher in ASAres patients (median value 311.4 vs. 646.3 pg/mL; p = 0.046) and right ventricular diameter was larger, whereas mean corpuscular hemoglobin concentration was lower as compared to patients with adequate response to ASA. Conclusions: ASAres has significant prevalence in this contemporary CAD cohort and NT-proBNP has been identified as the independent correlate of on-treatment ARU, representing a predictor for ASAres, along with right ventricular enlargement and lower hemoglobin concentration in erythrocytes.

Parathormone levels are independently associated with the presence of left ventricular hypertrophy in patients with coronary artery disease

2015 ◽  
Vol 20 (6) ◽  
pp. 659-664 ◽  
Author(s):  
Á. Aceña ◽  
A. M. Pello ◽  
R. Carda ◽  
Ó. Lorenzo ◽  
M. L. Gonzalez-Casaus ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Artery Disease
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