scholarly journals The choice of antihypertensive therapy in correction of cognitive impairments and prevention of dementia: possibilities of valsartan and fixed-dose combination of valsartan and hydrochlorothiazide

2016 ◽  
Vol 13 (4) ◽  
pp. 47-55
Author(s):  
O D Ostroumova ◽  
I A Garelik ◽  
E A Karavashkina
Keyword(s):  
Cognitive Function ◽  
Arterial Hypertension ◽  
Antihypertensive Drugs ◽  
Cognitive Impairments ◽  
Cerebral Protection ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Angiotensin Ii Receptor ◽  
Receptor Blockers ◽  
Dose Combination

This article discusses the definition, classification and pathogenetic mechanisms of cognitive functions in arterial hypertension. The authors discuss the capabilities of the different classes of antihypertensive drugs in correction of cognitive impairments and prevention of dementia. The authors also discuss the advantages of the angiotensin II receptor blockers in prevention of dementia and in their potential mechanisms of cerebral protection. The article describes in detail the possibilities of valsartan in correction of cognitive impairments associated with arterial hypertension, the advantages of valsartan in comparison with calcium antagonists and its unique neuroprotective mechanisms. We show our own results of the study concerning fixed-dose combination of valsartan and hydrochlorothiazide, and find out that this combination has high antihypertensive and cerebral protection (capacity to improve cognitive function) and effectiveness.

Development and validation of a UPLC-DAD method for the simultaneous quantification of eight antihypertensive drugs in the pharmaceutical matrix

2020 ◽  
Author(s):  
Miloud El Karbane ◽  
Yassine Hameda Benchekroun ◽  
Fatima Zahra Abousalih ◽  
Ismail Bennani ◽  
Mohamed Azougagh ◽  
...  
Keyword(s):  
Antihypertensive Drugs ◽  
Fixed Dose ◽  
Good Resolution ◽  
Buffer Solution ◽  
Pharmaceutical Dosage Forms ◽  
Ich Guidelines ◽  
Dihydropyridine Calcium Channel Blocker ◽  
Receptor Blockers ◽  
Dose Combination ◽  
Development And Validation

Abstract Background Hypertension is a critical health problem; it is a prevalent risk factor for cardiovascular disease. Many treatments to combat hypertension are available, while several patients are resistant to the standard therapeutic approaches. The association of two or more substances in a fixed-dose combination is effective and tolerated to substitute the standard therapeutic approach. Objective New UPLC-DAD method was developed and validated to assay a combination of eight antihypertensive drugs including a diuretic: hydrochlorothiazide, dihydropyridine calcium channel blocker: Amlodipine and angiotensin II type 1 receptor blockers (sartans): valsartan, candesartan, eprosartan, olmesartan, losartan, and irbesartan in the pharmaceutical matrix. Methods Chromatographic separation was performed on an Acquity® UPLC C18 1.7 µm 2.1 × 100 mm column, with a gradient of buffer solution and acetonitrile, in the proportion of (80:20 v/v). Results Good resolution was obtained, and an optimal analysis time of less than 5 min was achieved. The method was validated according to the International Conference on Harmonization (ICH) guidelines following the classical approach and accuracy profile, it is shown to be suitable for intended applications. The method was successfully used for quality control laboratories and the determination of these drugs combination in pharmaceutical dosage forms.

scholarly journals Effect of the fixed-dose combination Ekvator on blood pressure level and cognitive functions in elderly patients with arterial hypertension

2013 ◽  
Vol 10 (1) ◽  
pp. 76-79
Author(s):  
O D Ostroumova ◽  
E I Pervichko
Keyword(s):  
Blood Pressure ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Antihypertensive Drug ◽  
Cognitive Functions ◽  
Blood Pressure Level ◽  
Pressure Level ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination

The paper gives the data of the authors’ trial of the effect of the fixed-dose combination antihypertensive drug lisinopril + amlodipine on blood pressure level and cognitive functions in 25 elderly patients with grades 1–2 arterial hypertension. The test drug has a high antihypertensive efficacy, as shown by both routine blood pressure measurements and 24-hour monitoring data. The findings suggest that the fixed-dose combination antihypertensive drug lisinopril + amlodipine improves a number of parameters characterizing cognitive functions

scholarly journals Efficacy of a fixed-dose combination (amlodipine/losartan) in the treatment of a patient with arterial hypertension, dyslipidemia and obesity

2020 ◽  
pp. 74-78
Author(s):  
V. P. Mikhin
Keyword(s):  
Arterial Hypertension ◽  
Clinical Case ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
High Cardiovascular Risk ◽  
Steady Level ◽  
Dose Combination

The article substantiates the feasibility of combination antihypertensive therapy in patients with arterial hypertension without target organ damage and high cardiovascular risk. The authors consider a clinical case of the use of amlodipine and losartan in a fixed-dose combination (Lozap AM) as part of complex therapy in a patient with arterial hypertension, dyslipidemia and obesity. The clinical case showed the ability of the drug to both achieve a steady level of target blood pressure and improve its daily profile by transferring the Night-peaker type to the Non-dipper type.

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