Comparative study of transferring frozen embryo with short culture vresus overnight culture and also assess prevalence rate of psychological distress amongs infertility patient

Frozen embryo transfer is a procedure which is widely preferable technique to transfer of embryos obtained in assisted reproductive technology. The transfer of cryopreserved embryos transfer which is less expensive than the second fresh cycle, fertility treatment costs, can get an increased implantation rate, and an increased rate of pregnancy. The primary negative emotional reaction to both infertility and assisted reproductive therapy is typically either anxiety or depression. To compare serum β-hCG value in fresh frozen-thawed embryo transfer with overnight cultured frozen-thawed embryo transfer. And prevalence rate of psychological distress. 52 FET Cycles performed in between June to December 2018 among these embryos transfer 36 were performed within 1 hour after thawing and 16 were performed after overnight incubation. We observed that patient in 1 hour incubation has higher β-hCG level than overnight culture patients and there is worse psychological status in infertile women and nearly half of our infertile sample (51.9%) displayed mild to extreme depressive symptoms. Obstetricians should consider that reducing the mental and social issues will lead to greater happiness and productivity. If psychiatry disorders are chronic, it can affect adversely.

Download Full-text

Association between 7-day serum β-hCG levels after frozen–thawed embryo transfer and pregnancy outcomes: a single-centre retrospective study from China

BMJ Open ◽

10.1136/bmjopen-2019-035332 ◽

2020 ◽

Vol 10 (10) ◽

pp. e035332

Author(s):

Lihua Yuan ◽

Lingyu Yu ◽

Zhengao Sun ◽

Jingyan Song ◽

Jimei Xiao ◽

...

Keyword(s):

Retrospective Study ◽

Pregnancy Outcome ◽

Embryo Transfer ◽

Predictive Value ◽

Area Under The Curve ◽

Secondary Outcome ◽

Adverse Pregnancy ◽

Β Hcg ◽

Frozen Thawed Embryo Transfer ◽

Thawed Embryo Transfer

ObjectiveEarly monitoring of plasma human chorionic gonadotropin (β-hCG) level is vital in predicting pregnancy outcome. This study investigated the predictive value of serum β-hCG level on the seventh day after frozen–thawed embryo transfer (FET) for ongoing pregnancy (OP) and adverse pregnancy (AP).DesignRetrospective study.SettingThe Reproductive and Genetic Center of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China.Participants1061 pregnant women who underwent FET between January 2014 and January 2017.Primary and secondary outcome measuresPregnancy outcome.ResultsSerum β-hCG levels on the seventh day after FET were higher in the single OP group compared with the biochemical pregnancy group (p<0.001). Besides, the serum β-hCG cut-off level at 4.34 mIU/mL on the seventh day showed high predictive value (area under the curve (AUC)=0.852). Serum β-hCG levels on the seventh day after FET were higher in the twin OP group compared with the single OP group (p<0.001). Also, the serum β-hCG cut-off level at 17.95 mIU/mL on the seventh day showed high predictive value (AUC=0.903). Serum β-hCG levels on the seventh day after FET were lower in the ectopic pregnancy group compared with the single OP group (p<0.001) whereas, serum β-hCG cut-off level at 4.53 mIU/mL on the seventh day exhibited a high predictive value (AUC=0.860). Further, the serum β-hCG levels on the seventh day after FET were lower in the single early spontaneous abortion group compared with the single OP group (p<0.001) while the serum β-hCG cut-off level at 5.34 mIU/mL on the seventh day exhibited high predictive value (AUC=0.738).ConclusionSerum β-hCG on the seventh day after FET has good clinical significance for the prediction of OP and AP.

Download Full-text

Comparison of birthweights in patients randomly assigned to fresh or frozen-thawed embryo transfer

10.26226/morressier.573c1513d462b80296c98a23 ◽

2016 ◽

Author(s):

Bruce Shapiro

Keyword(s):

Embryo Transfer ◽

Frozen Thawed Embryo Transfer ◽

Thawed Embryo Transfer

Download Full-text

THE EFFECT OF ASSISTED HATCHING IN FROZEN-THAWED EMBRYO TRANSFER CYCLES

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2016.3.12 ◽

2016 ◽

pp. 80-84

Author(s):

Thi Tam An Nguyen ◽

Minh Tam Le ◽

Ngoc Thanh Cao

Keyword(s):

Embryo Transfer ◽

Zona Pellucida ◽

Assisted Hatching ◽

Implantation Failure ◽

Multiple Pregnancies ◽

Recurrent Implantation Failure ◽

Key Words Laser ◽

Implantation And Pregnancy Rates ◽

Frozen Thawed Embryo Transfer ◽

Thawed Embryo Transfer

Background: Laser assisted hatching technique based on the hypothesis to make an artificial hole on zona pellucida (ZP) that can help embryo hatching out of ZP easily. This technique has been shown to increase implantation and pregnancy rates in women of advanced age, in women with recurrent implantation failure and following the transfer of frozen–thawed embryos. This study described the outcome of frozen–thawed embryo transfers with laser assisted hatching (LAH), which is one of the safest method in nowadays. Purpose: To assess the effect of assisted hatching technique on the clinical outcomes in vitrified-warmed transfer cycles. Method: A total of 65 thawed-transfer cycles with 153 thawed-embryos undertaken within a 12-month period were analysed, Assisted hatching with laser zona thinning was performed with one-quarter of the zona pellucida circumference. The overall thawed-embryos (day 3) were kept in culture overnight. Patient were prepared the suitable endometrium and transferred embryos advantageously. Results: In which, having the rate of survival embryos were 143 occupying 94.3%, the percentage of grade 1 and 2 embryos occupied 55.9% and 29,3% respectively, and that were enrolled LAH before transfering of frozen–thawed embryos. The average transferred embryos were 2.4±0.8, The rate of implantation per transferred embryos and per transferred embryos cycles was 19.5% and 43.1% respectively. The rate of clinical pregnancies per embryo transfer cycles occupied 33.8% with percentage of early miscarriages (biochemical pregnancies and early clinical miscarriages) was 12.3%. The rate of ongoing pregnancies was 30.8% and multiple pregnancies was low just 12.3%. This result was equal or higher than other researchs in embryos transfer had or no LAH. Conclusion: LAH contributed to stable frozen–thawed embryos transfer effectiveness. Key words: Laser assisted hatching, frozen–thawed embryos transfer, zona pellucida (ZP)

Download Full-text