Analysis of various treatment modalities of herpetic lesions

Herpes Simplex Virus (HSV) is a debilitating infectious disease, often the root cause of all oral herpetic lesions. The oral herpes virus affects the individuals aesthetically, healthwise, and psychologically as well. The aim of the study is to analyze and evaluate the various treatment modalities practiced at the Department of Oral Medicine at Saveetha Dental College and Hospital, Chennai. A total of 64 participants were involved in the study conducted between the period of July 2019 - March 2020. The patients were receiving either of the following treatment: (i) Topical antivirals (ii) Topical anti-inflammatory or analgesics (iii) Systemic antivirals (iv) Systemic antipyretics (v) Supportive therapy if any. The result of the study conducted shows the prevalence of usage of 57% of topical antivirals, 12% of systemic antivirals, 12% of topical anti-inflammatory and analgesics, 13% of systemic antipyretics and 6% of supportive therapy. In conclusion, the topical antiviral drugs prescribed were of high prevalence. However, advising necessary supportive therapy can help in faster healing of the lesions.

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Penatalaksanaan infeksi herpes simpleks oral rekuren Management of recurrent oral herpes simplex infection

Journal of Dentomaxillofacial Science ◽

10.15562/jdmfs.v12i1.345 ◽

2013 ◽

Vol 12 (1) ◽

pp. 28

Author(s):

Erni Marlina ◽

Bagus Soebadi

Keyword(s):

Herpes Simplex ◽

Supportive Therapy ◽

Herpes Simplex Infection ◽

Virus Reactivation ◽

Oral Herpes ◽

Simplex Infection ◽

Oral Tissue ◽

Infection Patient ◽

Simplex Virus ◽

Tissue Trauma

Recurrent oral herpes simplex infection was the secondary or recurrent form of primary herpes simpex infection. Inhuman, herpes simplex virus was latent or dormant and could reactivate. Recurrency due to virus reactivation inducedby emotional stress, high fever, ultraviolet exposed, oral tissue or neuron tissue trauma, immunosuppresion condition,and hormonal disturbance. The aim of this paper was to report and discuss management of recurrent oral herpessimplex infection which complicated in the diagnosis due to manifestation of both herpes labialis and intraoral lesionform resembling herpes simplex infection. Patient was a 22 years- old woman, came to Installaton of Dental, dr.Soetomo Hospital with chief complaint pain were soreness caused by ulcer on the tongue accompanied by tingling nearthe upper labial mucosal. Patient was prescribed with acyclovir as causative therapy, mouthwash contain extract ofaloe vera, multivitamins and immunomodulator as supportive therapy. Patient healed 4 days after the first visit. It wasconcluded that this case was diagnosed clinically as recurrent oral herpes simplex infections. Causative therapy withacyclovir administration showed excellent response, as well as supportive therapy immunomodulator that supportedimprovement of the immune system so that the frequency of recurrence can be reduced.

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Antiviral Action of Synthetic Stigmasterol Derivatives on Herpes Simplex Virus Replication in Nervous CellsIn Vitro

BioMed Research International ◽

10.1155/2014/947560 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Erina Petrera ◽

Analía G. Níttolo ◽

Laura E. Alché

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Cell Lines ◽

Antiviral Effect ◽

Treatment Modalities ◽

Virus Propagation ◽

Viral Origin ◽

Anti Inflammatory ◽

Simplex Virus ◽

Hsv 1

Polyfunctionalized stigmasterol derivatives, (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (compound1) and (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (compound2), inhibit herpes simplex virus type 1 (HSV-1) replication and spreading in human epithelial cells derived from ocular tissues. Both compounds reduce the incidence and severity of lesions in a murine model of herpetic stromal keratitis when administered in different treatment modalities. Since encephalitis caused by HSV-1 is another immunopathology of viral origin, we evaluate here the antiviral effect of both compounds on HSV-1 infected nervous cell lines as well as their anti-inflammatory action. We found that both stigmasterol derivatives presented low cytotoxicity in the three nervous cell lines assayed. Regarding the antiviral activity, in all cases both compounds prevented HSV-1 multiplication when added after infection, as well as virus propagation. Additionally, both compounds were able to hinder interleukin-6 and Interferon-gamma secretion induced by HSV-1 infection in Neuro-2a cells. We conclude that compounds1and2have exerted a dual antiviral and anti-inflammatory effect in HSV-1 infected nervous cell lines, which makes them interesting molecules to be further studied.

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