Clinical and haematological profile of sickle cell disease in rural area of western ghats of India

The Exercise Capacity (ExC) of children with sickle cell disease (SCD) may be influenced negatively by both haematological and environmental factors.This study aimed to assessthe influence of haematological profile on the ExC of children with SCD in Kano and to ascertain the safety of conducting 6 minute walk test (6MWT) on those children. In the cross-sectional survey, 162 children were recruited from Murtala Mohammed SpecialistHospital, Kano. Each of them walked to-and-fro for 6 minutes on a 10 meter marked level floor at their own walking pace in order to determine their actual 6 minute walk distance (6MWD). The actual 6MWD was compared with a predicted one in order to determine their ExC. Full blood count was used to evaluate haematological profiles. The data wereanalysed with Pearson product moment correlation and unpaired t test, at a level of significance of p<0.05 using SPSS version 20. Results showed that seventy (70) males (43.2%) and ninety two (92) females (56.8%) with mean age of 10.7±3.27 years took part in the study. The actual 6MWD was 366.20 m ± 59.88m (95%CI=356.91m - 375.49m) which was 59.17% of the predicted one. ExCcorrelated with each of White blood cell count (WBC)(r= - 0.22; p=0.005), Sex (r= - 0.27; p=0.001) and age (r=0.19; p=0.013). None of the participants experienced exercise-induced vaso-occlusive crisis during or immediately after the 6MWT.It was concluded that infection (signified by increased WBC count) and female gender have negative influence on ExC. 6MWT is safe to be performed by children with SCD.

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CLINICO-HAEMATOLOGICAL PROFILE OF HEMOLYTIC ANEMIA IN CHILDREN

10.36106/gjra/4503075 ◽

2020 ◽

pp. 12-14

Author(s):

Vipin Tewani ◽

Shraddha Shete ◽

Rithika Dante

Keyword(s):

Sickle Cell Disease ◽

Hemolytic Anemia ◽

Sickle Cell ◽

Growth Parameters ◽

Research Centre ◽

Beta Thalassemia ◽

Cell Disease ◽

Parental Awareness ◽

Study Results ◽

Haematological Profile

Background: The purpose of study is to evaluate clinical profile of children with hemolytic anemia with necessary investigation along with growth parameters of these children with reference to anemia and parental awareness to recognize the degree of pallor in their affected children. Methods: The study was carried out in patients of Krishna hospital and Medical research centre,Karad in period of January 2018 to august 2018 .A total of 36 cases were included in the study.Children aged between 4 months to 12 years diagnosed to have hemolytic anemia, those who had given consent, those who came to our hospital for blood transfusion were included in study. Results: Among the study, sickle cell disease ,sickle beta thalassemia and sickle beta thalassemia trait are present in majority of the patients (61.09%). Beta thalassemia major along with beta thalassemia intermedia is present in 38.88% of the cases. Conclusion:Sickle beta thalassemia and sickle cell disease forms the major types of hemolytic anemia .Parental awareness of presence of paleness and anemia is poor. No relation to religion , social group and consanguinity .

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Knowledge, attitude and practice regarding sickle cell disease in adult sufferers and carriers in a rural area

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20171327 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1075

Author(s):

Sonali S. Patil ◽

Anand A. Thikare ◽

Sarita K. Wadhva ◽

Uday W. Narlawar ◽

Shruti Shukla

Keyword(s):

Sickle Cell Disease ◽

Rural Area ◽

Sickle Cell ◽

Cross Sectional Study ◽

Cell Disease ◽

Cross Sectional ◽

Correct Knowledge ◽

Treatment And Prevention ◽

Positive Treatment ◽

Premarital Screening

Background: According to State Health Society, there are about 30 lakhs sickle cell carrier and 1.5 lakhs sufferers in Maharashtra, prevalence being more in tribal population. As Sickle cell disease is associated with increased morbidity and mortality, it is important for patients to have awareness regarding its cause, treatment and genetic implication. To assess Knowledge, Attitude and Practices regarding sickle cell disease in adult sufferers and carriers.Materials and Methods: The present study is an cross sectional study, carried out in 232 adult sickle cell disease sufferers and carriers in rural area of Chandrapur district from July 2014 to December 2015.Results: Out of 232 study subjects, 17.24% were sufferers and 82.76% were carriers. Only 62.50% knew the correct cause and only 42.67% had correct knowledge of types of disease. 76.30% had correct knowledge about symptoms of disease. 40.09% patients were availing treatment of some kind. It was found that only 6.77% had done premarital screening of their spouses and 100% had screened their children for sickle cell disease.Conclusion: Knowledge regarding sickle cell disease, its cause, types, treatment and prevention is satisfactory in sufferers but not in carriers. Overall attitude towards treatment and prevention is more or less positive. Treatment seeking behavior is good in sufferers but not in carriers.

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