scholarly journals The Role of Activin-A in the Etiopathogenesis of Nasal Polyposis

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Hakan Dağıstan ◽  
Mete Bozkurt ◽  
Çağdaş Elsürer ◽  
Pınar Karabağlı
Keyword(s):  
Nasal Polyposis ◽  
Activin A

scholarly journals The Role of Activin A and B and the Benefit of Follistatin Treatment in Renal Ischemia-Reperfusion Injury in Mice

2016 ◽  
Vol 2 (7) ◽  
pp. e87 ◽  
Author(s):  
Doreen Y.P. Fang ◽  
Bo Lu ◽  
Susan Hayward ◽  
David M. de Kretser ◽  
Peter J. Cowan ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Activin A ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury

The role of omalizumab in the treatment of chronic rhinosinusitits with nasal polyposis

2021 ◽  
Author(s):  
Jeffrey P Aldinger ◽  
Taylor Dobyns ◽  
Kent Lam ◽  
Joseph K Han
Keyword(s):  
Nasal Polyposis

Abstract 172: The Role of Activin A in Maternal Diabetes-Induced Cardiac Malformations

2012 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
Zhiyong Zhao
Keyword(s):  
High Glucose ◽  
Heart Defects ◽  
Maternal Diabetes ◽  
Activin A ◽  
Brdu Incorporation ◽  
Control Group ◽  
Endocardial Cushions ◽  
Diabetic Embryopathy ◽  
Cardiac Malformations

Diabetes mellitus in pregnancy causes heart defects, especially atrioventricular septal defects (AVSDs), in infants. Manifestation of AVSDs results from dysmorphogenesis of the endocardial cushions in the embryo, which is regulated by members of the transforming growth factor (TGF) β family. Among the TGFβs, we have previously observed that the inhibin βA gene, which encodes a protein to form homodimers as activin A, is markedly downregulated by maternal diabetes. To further determine the involvement of inhibin βA and its signaling in diabetic embryopathy, the levels of inhibin βA protein and activation of its downstream transcription factors, Smad2 and Smad3, were examined using immunohistochemical, proximity ligation, and immunoblot assays, and shown to be decreased in the embryonic hearts of diabetic mice induced via intravenous injection of streptozotocin. To investigate the role of activin A in hyperglycemia-induced cardiac malformations, mouse embryos at embryonic day 9.5 (E9.5) cultured in high glucose (22 mM) were treated with activin A (50 ng/ml) for 24 hours. The treatment rescued the development of the endocardial cushions and cell proliferation (BrdU-incorporation assay) in the myocardium, similar to those in normal glucose control (8.3 mM). The role of activin A in endocardial cell migration, an important process for cellularization of the cardiac jelly, was investigated by treating E10.5 endocardial cushion explants cultured in high glucose with activin A (50 ng/ml) in a collagen matrix-based assay system. The treatment significantly increased the number of migrating cells, compared with that in high glucose-treated group, to the level in the control group. These effects were associated with restoration of the activation of Smad2/3. The results demonstrate that the activin-Smad2/3 signaling system plays an important role in cardiac malformation in diabetic embryopathy.

Sinonasal Surfactant Protein A1, A2, and D Gene Expression in Cystic Fibrosis: A Preliminary Report

2007 ◽  
Vol 137 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Bradford A. Woodworth ◽  
Rachel Wood ◽  
John E. Baatz ◽  
Rodney J. Schlosser
Keyword(s):  
Gene Expression ◽  
Cystic Fibrosis ◽  
Nasal Polyposis ◽  
Quantitative Polymerase Chain Reaction ◽  
Surfactant Protein ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Novel Treatment ◽  
Polymerase Chain

OBJECTIVE: To measure alterations in SPA1, A2, and D gene expression in various forms of inflammatory chronic rhinosinusitis (CRS). STUDY DESIGN AND SETTING: Sinus mucosal biopsies were performed in patients with allergic fungal rhinosinusitis (AFS), CRS with nasal polyposis, cystic fibrosis (CF), and controls. SP mRNA was measured with quantitative polymerase chain reaction. RESULTS: Patients with CF (n = 4) showed significantly increased SPA1 (82-fold), SPA2 (100-fold), and SPD (47-fold) mRNA ( P < 0.05) when compared with controls (n = 5). Patients with CRS with nasal polyposis (n = 5) also demonstrated elevated SPA1 (27-fold), SPA2 (13-fold), and SPD (13-fold). Patients with AFS (n = 7) had increased SPA1 (5-fold), SPA2 (9-fold), and SPD (17-fold), but were not statistically significant. CONCLUSION: SPA1, A2, and D are upregulated in various forms of CRS, but are significantly elevated in cystic fibrosis CRS. SIGNIFICANCE: Understanding the role of SPs in CRS will help develop novel treatment approaches for sinonasal pathoses.

scholarly journals A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo

2009 ◽  
Vol 6 (5) ◽  
pp. 387-392 ◽  
Author(s):  
Yinan Wang ◽  
Xueling Cui ◽  
Guixiang Tai ◽  
Jingyan Ge ◽  
Nan Li ◽  
...  
Keyword(s):  
Critical Role ◽  
Peritoneal Macrophages ◽  
Activin A ◽  
Mouse Peritoneal Macrophages

The Role of Atopy in Nasal Polyposis

2011 ◽  
Vol 02 (02) ◽  
Author(s):  
Rakesh Chandra
Keyword(s):  
Nasal Polyposis

Ingrained Insight into Nasal Polyposis; Role of Human Papillomavirus: An Indian Study

2020 ◽  
Author(s):  
M. B. Bharathi ◽  
Sreenivas Kamath Kasaragod ◽  
S. Basavaraj ◽  
B. G. Prakash
Keyword(s):  
Human Papillomavirus ◽  
Nasal Polyposis ◽  
Indian Study ◽  
Insight Into

S277 – The Role of Helicobacter Pylori in Nasal Poliposis

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P167-P168
Author(s):  
Engin Çekin ◽  
Bulent Evren Erkul ◽  
Hakan Cincik ◽  
Salim Dogru ◽  
Atila Gungor ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Disease Severity ◽  
Computerized Tomography ◽  
Reflux Disease ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Sinus Surgery ◽  
Significant Difference ◽  
H Pylori

Objectives 1) To investigate the role of Helicobacter pylori in etiopathogenesis of nasal polyposis. 2) To compare the severity of nasal polyposis disease with presence of Helicobacter pylori. Methods This study was performed on 35 patients (29 male, 6 female; aged between 17 and 77) who applied to GATA Haydarpasa Training Hospital Otolaryngology Clinic in 2006 and 2007. They all complained of nasal obstruction and were diagnosed as nasal polyposis after examination. Samples taken from all patients during endoscopic sinus surgery were subjected to cetyl metil amonium bromur (STAB) method to purify DNA of Helicobacter pylori(H. pylori). All patients were evaluated for reflux disease. Severity of nasal polyposis disease was compared with presence of H. pylori by performing endoscopic nasal examination and computerized tomography. Results H. Pylori was found negative for 24 patients (%68,6) and positive for 11 patients (%31,4). There was no statistically significant difference between presence of H. pylori and that of reflux disease in nasal polyposis (p>0.05). Difference between presence of H. pylori and results of endoscopic nasal examination and computerized tomography was not statistically significant (p>0.05). Conclusions We found that presence of H. pylori and reflux disease are not associated with etiopathogenesis of nasal polyposis.

Role of Staphylococcal Enterotoxin B on the Differentiation of Regulatory T Cells in Nasal Polyposis

2014 ◽  
Vol 28 (1) ◽  
pp. e17-e24 ◽  
Author(s):  
Soo-Na Cho ◽  
Chang-Hwa Song ◽  
Jun Jin ◽  
Sung Ha Kim ◽  
Ki-Sang Rha ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nasal Polyposis ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B
Sign in / Sign up

Export Citation Format

Share Document