Effects of A Gentle Gymnastics Program on the Quality of Walking and Quality of Life of Patients with Regional Painful Knee Complex Type I Pain Syndrome: Case Study

A 23-year-old woman was referred to the allergy and immunology clinic for recurrent abdominal, cutaneous and joint swelling and pain with a history of mucosal infections since childhood. Her history and clinical findings were suggestive of two rare and complex disorders, hereditary angioedema (HAE) and Ehlers-Danlos syndrome (EDS). Her recurrent episodes of abdominal and joint pain were initially misattributed to more common diagnoses such as esophagitis, depression and chronic pain syndrome. However, the coexistence of HAE and EDS likely contributed to a delay in diagnoses as the combination of these two rare but overlapping disorders is less understood by physicians. She had persistently low levels of C4 and C1-esterase inhibitor (C1-INH) with low to low-normal C1-esterase function, normal C1Q and no C1Q antibodies. In the setting of recurrent abdominal pain with cutaneous swelling, this supported the diagnosis of HAE type I. The increase in joint extensibility with recurrent shoulder subluxations since childhood was a manifestation of EDS. Although no known genetic mutations were identified for EDS, her diagnosis was confirmed by a geneticist based on her clinical phenotype. Before the diagnosis of HAE and EDS, our patient had at least 100 visits/year to the emergency department/hospitalisations for these recurrent symptoms. After starting on C1-INH replacement therapy, the frequency has decreased 10-fold. She also noted a 70% improvement in her quality of life. Familiarity with these rare disorders will assist healthcare providers in recognising HAE and EDS and include them as part of their differential diagnoses. Early diagnosis is important for a patient’s well-being as both these chronic disorders have been associated with poor quality of life. Additionally, proper diagnoses will reduce healthcare costs by preventing unnecessary procedures due to misdiagnoses. Proper treatment will help to decrease hospitalisations and avoidance of life-threatening consequences (such as asphyxiation from fatal laryngeal attacks of HAE and rupture of aneurysms in EDS).

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Quality of life in adults with childhood-onset of Complex Regional Pain Syndrome type I

Injury ◽

10.1016/j.injury.2009.01.134 ◽

2009 ◽

Vol 40 (8) ◽

pp. 901-904 ◽

Cited By ~ 30

Author(s):

Edward C.T.H. Tan ◽

Nienke van de Sandt-Renkema ◽

Paul F.M. Krabbe ◽

Daniel C. Aronson ◽

René S.V.M. Severijnen

Keyword(s):

Quality Of Life ◽

Complex Regional Pain Syndrome ◽

Pain Syndrome ◽

Type I ◽

Syndrome Type ◽

Childhood Onset

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Complex regional pain syndrome type I in children. Clinical description and quality of life

Orthopaedics & Traumatology Surgery & Research ◽

10.1016/j.otsr.2015.06.013 ◽

2015 ◽

Vol 101 (6) ◽

pp. 745-748 ◽

Cited By ~ 8

Author(s):

X. Bayle-Iniguez ◽

C. Audouin-Pajot ◽

J. Sales de Gauzy ◽

C. Munzer ◽

J. Murgier ◽

...

Keyword(s):

Quality Of Life ◽

Complex Regional Pain Syndrome ◽

Pain Syndrome ◽

Type I ◽

Syndrome Type ◽

Clinical Description

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Health-Related Quality of Life in Chronic Refractory Reflex Sympathetic Dystrophy (Complex Regional Pain Syndrome Type I)

Journal of Pain and Symptom Management ◽

10.1016/s0885-3924(00)00170-6 ◽

2000 ◽

Vol 20 (1) ◽

pp. 68-76 ◽

Cited By ~ 44

Author(s):

Marius A Kemler ◽

Henrica C.W de Vet

Keyword(s):

Quality Of Life ◽

Complex Regional Pain Syndrome ◽

Reflex Sympathetic Dystrophy ◽

Pain Syndrome ◽

Type I ◽

Syndrome Type ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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AB0605 ACTIGRAPHY-BASED PHYSICAL ACTIVITY MONITORING IN PATIENTS WITH KNEE OSTEOARTHRITIS AND COMORBID FIBROMYALGIA

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.4189 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1338.2-1339

Author(s):

O. Dzekan

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Knee Osteoarthritis ◽

Diagnostic Criteria ◽

Pain Syndrome ◽

Moderate Activity ◽

Healthy Individuals ◽

Knee Oa ◽

Painful Knee

Background:Low physical activity (PA) levels are common in patients with diseases associated with pain syndrome, such as osteoarthritis (OA) of the knee joints. Recent studies show that OA may be accompanied by concomitant fibromyalgia (FM) – a chronic pain syndrome associated with sedentary behavior [1]. As far as low PA levels are associated with poor quality of life and higher all-cause mortality, PA measurement in patients with knee OA and concomitant FM is of considerable interest [2,3].Objectives:The aim of this study was to investigate and compare physical activity measured by an actigraph in knee OA patients with and without comorbid FM.Methods:A total of 70 patients with painful knee osteoarthritis (OA) – 35 subjects - (30 females and 5 males) with concomitant fibromyalgia (FM) aged 59.8±14.9 (M±SD) years and 35 patients (30 females and 5 males) without concomitant FM aged 58.5±15.7 (M±SD) years were enrolled in the study. 35 healthy controls of the same age and gender underwent the same investigation. OA diagnosis was established according to ACR 1986 Osteoarthritis Knee Criteria. FM was diagnosed if both modified 2010 ACR diagnostic criteria and 2016 Fibromyalgia Diagnostic Criteria were met. All participants wore an actigraph (GT3X model accelerometer) on the wrist for the period of 5 working days. Average daily minutes in light, moderate and vigorous PA were calculated.Results:All OA patients with and without FM spent significantly less time in vigorous PA compared to controls. Obtained results did not indicate significant difference between time in vigorous activity in OA patients with and without FM. Patients with OA alone showed insignificant decrease in time in moderate activity in comparison with healthy subjects. OA patients with comorbid FM showed significantly less time in moderate activity compared to OA patients without FM and healthy individuals.Conclusion:Our study results revealed that patients with painful knee OA and comorbid FM have greater activity limitations than patients with painful knee OA alone and healthy individuals.References:[1]Mahgoub MY, Elnady BM, Abdelkader HS, Abdelhalem RA, HassanWA. Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life. Open Access Rheumatol. 2020;12: 55—63.[2]Ali K. Q. Al-Rubaye, Klara Johansson, Laith Alrubaiy. The association of health behavioral risk factors with quality of life in northern Sweden—A cross-sectional survey. J Gen Fam Med. 2020 Sep; 21(5): 167–177.[3]GBD 2017 Mortality Collaborators. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1684–735. pmid:30496102Disclosure of Interests:None declared.

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Complex Regional Pain Syndrome type I (CRPS I) and self-rehabilitation: A health-related quality of life study

Annals of Physical and Rehabilitation Medicine ◽

10.1016/j.rehab.2016.07.330 ◽

2016 ◽

Vol 59 ◽

pp. e148

Author(s):

Nicolas Winisdoerffer ◽

Marie-Madeleine Leclercq ◽

Aurélie Muller ◽

Myriam Martin ◽

Myriam Pierrat

Keyword(s):

Quality Of Life ◽

Complex Regional Pain Syndrome ◽

Pain Syndrome ◽

Type I ◽

Syndrome Type ◽

Health Related Quality ◽

Life Study ◽

Related Quality ◽

Health Related

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Misophonia: An Evidence-Based Case Report

American Journal of Audiology ◽

10.1044/2020_aja-19-00111 ◽

2020 ◽

Vol 29 (4) ◽

pp. 685-690

Author(s):

C. S. Vanaja ◽

Miriam Soni Abigail

Keyword(s):

Quality Of Life ◽

Case Report ◽

Case History ◽

Pure Tone ◽

Physiological Responses ◽

Evidence Based ◽

Management Option ◽

Pure Tone Audiogram

Purpose Misophonia is a sound tolerance disorder condition in certain sounds that trigger intense emotional or physiological responses. While some persons may experience misophonia, a few patients suffer from misophonia. However, there is a dearth of literature on audiological assessment and management of persons with misophonia. The purpose of this report is to discuss the assessment of misophonia and highlight the management option that helped a patient with misophonia. Method A case study of a 26-year-old woman with the complaint of decreased tolerance to specific sounds affecting quality of life is reported. Audiological assessment differentiated misophonia from hyperacusis. Management included retraining counseling as well as desensitization and habituation therapy based on the principles described by P. J. Jastreboff and Jastreboff (2014). A misophonia questionnaire was administered at regular intervals to monitor the effectiveness of therapy. Results A detailed case history and audiological evaluations including pure-tone audiogram and Johnson Hyperacusis Index revealed the presence of misophonia. The patient benefitted from intervention, and the scores of the misophonia questionnaire indicated a decrease in the severity of the problem. Conclusions It is important to differentially diagnose misophonia and hyperacusis in persons with sound tolerance disorders. Retraining counseling as well as desensitization and habituation therapy can help patients who suffer from misophonia.

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Chronic Refractory Cough: A Case Study

Perspectives of the ASHA Special Interest Groups ◽

10.1044/persp2.sig3.57 ◽

2017 ◽

Vol 2 (3) ◽

pp. 57-62

Author(s):

Anna Maria Siciliano

Keyword(s):

Quality Of Life ◽

Adult Female ◽

Chronic Cough ◽

Treatment Regime ◽

Speech Language Pathology ◽

Old Adult ◽

Language Pathology

This paper presents a successful behavioral case study in treatment of chronic refractory cough in a 60-year-old adult female. The efficacy for speech-language pathology treating chronic cough is discussed along with description of treatment regime. Discussion focuses on therapy approaches used and the patient's report of changes in quality of life and frequency, duration, and severity reduction of her cough after treatment.

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