AB0605 ACTIGRAPHY-BASED PHYSICAL ACTIVITY MONITORING IN PATIENTS WITH KNEE OSTEOARTHRITIS AND COMORBID FIBROMYALGIA

Background:Low physical activity (PA) levels are common in patients with diseases associated with pain syndrome, such as osteoarthritis (OA) of the knee joints. Recent studies show that OA may be accompanied by concomitant fibromyalgia (FM) – a chronic pain syndrome associated with sedentary behavior [1]. As far as low PA levels are associated with poor quality of life and higher all-cause mortality, PA measurement in patients with knee OA and concomitant FM is of considerable interest [2,3].Objectives:The aim of this study was to investigate and compare physical activity measured by an actigraph in knee OA patients with and without comorbid FM.Methods:A total of 70 patients with painful knee osteoarthritis (OA) – 35 subjects - (30 females and 5 males) with concomitant fibromyalgia (FM) aged 59.8±14.9 (M±SD) years and 35 patients (30 females and 5 males) without concomitant FM aged 58.5±15.7 (M±SD) years were enrolled in the study. 35 healthy controls of the same age and gender underwent the same investigation. OA diagnosis was established according to ACR 1986 Osteoarthritis Knee Criteria. FM was diagnosed if both modified 2010 ACR diagnostic criteria and 2016 Fibromyalgia Diagnostic Criteria were met. All participants wore an actigraph (GT3X model accelerometer) on the wrist for the period of 5 working days. Average daily minutes in light, moderate and vigorous PA were calculated.Results:All OA patients with and without FM spent significantly less time in vigorous PA compared to controls. Obtained results did not indicate significant difference between time in vigorous activity in OA patients with and without FM. Patients with OA alone showed insignificant decrease in time in moderate activity in comparison with healthy subjects. OA patients with comorbid FM showed significantly less time in moderate activity compared to OA patients without FM and healthy individuals.Conclusion:Our study results revealed that patients with painful knee OA and comorbid FM have greater activity limitations than patients with painful knee OA alone and healthy individuals.References:[1]Mahgoub MY, Elnady BM, Abdelkader HS, Abdelhalem RA, HassanWA. Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life. Open Access Rheumatol. 2020;12: 55—63.[2]Ali K. Q. Al-Rubaye, Klara Johansson, Laith Alrubaiy. The association of health behavioral risk factors with quality of life in northern Sweden—A cross-sectional survey. J Gen Fam Med. 2020 Sep; 21(5): 167–177.[3]GBD 2017 Mortality Collaborators. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1684–735. pmid:30496102Disclosure of Interests:None declared.

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INTERRELATION BETWEEN THE CHANGES IN QUALITY OF LIFE AND ARTERIAL STIFFNESS IN PATIENTS WITH DIABETES MELLITUS TYPE 2 AND CONCOMITANT OBESITY

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.18.4.71 ◽

2018 ◽

Vol 18 (4) ◽

pp. 71-75

Author(s):

I.M. Fushtey ◽

Ye.A. Solovyuk ◽

A.O. Solovyuk

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Diabetes Mellitus ◽

Emotional State ◽

Eating Behaviour ◽

Overweight And Obesity ◽

Healthy Individuals ◽

Patients With Diabetes

The purpose of this work was to study the general characteristics of quality of life (QoL), the effect of overweight on QoL, the nature of eating behaviour in patients with diabetes mellitus (DM) type 2 and concomitant overweight (OW) and obesity, as well as to establish the correlation with indicators of functional state of the arterial vessels. 64 people (34 women and 30 men) with DM and concomitant overweight and obesity (average age 56.3 ± 10.23 years) formed the 1 group, 34 people (19 women and 15 men), whose average age was 55.6 ± 11.92 years constituted the 2 group, and 28 healthy individuals formed the control group. SF-36v2 questionnaires were used to evaluate QoL. The effect of overweight on QoL was analyzed according to the IWQOL-Lite questionnaire data, the patterns of eating behaviour were determined by the COEQ4 for 7 days using FPRS questionnaire. The functional state of the arterial vessels was assessed by estimating the pulse wave velocity using the automated rheographic complex ReoCom (KhAI Medika (Ukraine)). The patients with DM and concomitant overweight and obesity were found to experience some changes in QoL according to the SF-36v2 questionnaire. The changes were primarily characterized by a decrease in physical activity, as well as in social and emotional status. These changes differed not only from the QoL assessment by healthy individuals, but also from those of patients with DM and normal body weight. The nature of eating behaviour in overweight or obese patients with DM was characterized by an increased hunger in parallel with a worsened emotional state and an increased desire to eat certain types of foods that can contribute to weight gain. Structural changes in arterial vessels that typically are indicative of arterial stiffness correlate with indicators of emotional state and physical activity in patients with DM and comorbid overweight and obesity.

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Relation of physical activity level with quality of life, sleep and depression in patients with knee osteoarthritis

Northern Clinics of Istanbul ◽

10.14744/nci.2015.95867 ◽

2016 ◽

Cited By ~ 2

Author(s):

Erkan Mesci

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Knee Osteoarthritis ◽

Physical Activity Level ◽

Activity Level

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Customized Foot Insoles Have a Positive Effect on Pain, Function, and Quality of Life in Patients with Medial Knee Osteoarthritis

Journal of the American Podiatric Medical Association ◽

10.7547/1030050 ◽

2013 ◽

Vol 103 (1) ◽

pp. 50-55 ◽

Cited By ~ 12

Author(s):

Søren Thorgaard Skou ◽

Lea Hojgaard ◽

Ole H. Simonsen

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Older Adults ◽

Knee Osteoarthritis ◽

Visual Analog Scale ◽

Oxford Knee Score ◽

Analog Scale ◽

Custom Made ◽

Arch Support

Background: Knee osteoarthritis (KOA) is a prevalent degenerative disease in older adults. Treatment strategies, including insoles, focus on reducing pain and physical disability. In medial KOA, insoles have been studied extensively with conflicting results, possibly due to heterogeneity in outcome measures and the intervention. We sought to investigate the effect of custom-made laterally wedged insoles on pain, function, and quality of life in patients with medial KOA. Methods: Fifty-one consecutive patients with medial KOA were prescribed custom-made insoles with arch support and a 5.0° to 8.7° lateral wedge. At follow-up, 42 of the 51 participants (22 men; mean age, 63 years; mean Kellgren-Lawrence, 3.4) participated. Retrospectively, participants were asked to rate the pain intensity in their affected knee before and after the intervention measured on a visual analog scale after 30 min of physical activity (primary outcome), at rest, at night, and after 50 m of walking. Additionally, they completed the Oxford Knee Score and the EQ-5D. The paired-samples t test was applied in the statistics. Results: The visual analog scale score after 30 min of physical activity was significantly reduced after the intervention (mean, 3.3 cm; 95% confidence interval, 2.1–4.5 cm; P < .001). The same significant changes were found in all of the secondary outcomes. Conclusions: There was a significant reduction in pain and improvements in function and quality of life with custom-made laterally wedged insoles with arch support in older adults with mild-to-severe medial KOA. The customization of laterally wedged insoles may be essential for the effect in medial KOA. (J Am Podiatr Med Assoc 103(1): 50–55, 2013)

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Effects of weight change and physical activity on knee pain and health-related quality of life in East Asian women aged 50 years and older with knee osteoarthritis: a population-based study

10.21203/rs.2.12546/v1 ◽

2019 ◽

Author(s):

Chongbum Chang ◽

Young Choi ◽

Seung-Baik Kang ◽

Chin Youb Chung ◽

Moon Seok Park ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Knee Osteoarthritis ◽

Knee Pain ◽

Weight Change ◽

Population Based ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Abstract Background This study aimed to investigate the effects of weight change and physical activity on the level of knee pain and health-related quality of life in East Asian women with knee osteoarthritis using population-based data. Methods A total of 564 women (mean age, 68.2 years, standard deviation, 8.9 years) aged 50 years or older with knee osteoarthritis (Kellgren-Lawrence grade ≥2) were included in the data analyses from the fifth Korea National Health and Nutrition Examination Survey. Data regarding the radiographic grade, weight change during the past year, physical activity, level of knee pain, and health-related quality of life (EuroQOL five-dimension [EQ-5D] index) were collected. Multiple regression analysis was performed to identify factors significantly affecting the level of knee pain and health-related quality of life in subgroups according to the body mass index (BMI) range (≤22.5, between 22.6 and 27.5, and >27.5 kg/m2). Result In women with 22.5 kg/m227.5 kg/m2, weekly hours of moderate-intensity activity showed significant negative correlation with EQ-5D. Conclusions The effects of weight change and physical activity on knee pain and health-related quality of life could be different according to BMI ranges. Well-designed interventions to improve both knee pain and health-related quality of life need to be investigated in future studies that would assess physical activity, diet, and weight changes.

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Effects of variable frequencies of kinesthesia, balance and agility exercise program in adults with knee osteoarthritis: study protocol for a randomized controlled trial

10.21203/rs.3.rs-28963/v2 ◽

2020 ◽

Author(s):

Aysha I. Adhama ◽

Mukadas O. Akindele ◽

Aminu A. Ibrahim

Keyword(s):

Quality Of Life ◽

Randomized Controlled Trial ◽

Knee Osteoarthritis ◽

Conventional Therapy ◽

Controlled Trial ◽

Hip Osteoarthritis ◽

Life Questionnaire ◽

Knee Oa ◽

Randomized Controlled

Abstract Background: Knee osteoarthritis (OA) is a common painful and disabling condition that affects older individuals. Proprioceptive training programs in the form of kinesthesia, balance and agility (KBA) exercises have been reported to be beneficial for individuals with knee OA. However, the most optimal treatment dosage of KBA exercise is still unclear. The aim of this study is to determine the effects of different frequencies of KBA treatment (i.e. twice-weekly or thrice-weekly) in adults with knee OA.Methods: A single (assessor) blind, three-arm parallel, multi-center randomized controlled trial will be conducted. Eighty-four adults with knee OA will be recruited from four tertiary hospitals in Northwestern Nigeria and randomly assigned into one of three intervention groups; twice-weekly KBA (n = 28), thrice-weekly KBA (n = 28), and conventional physiotherapy or control (n = 28) in the ratio of 1:1:1. Participants in the conventional therapy group will receive two sessions of brief patient education, and 16 sessions of ultrasound therapy, stretching and strengthening exercises for 8 weeks. Participants in the two different KBA groups will receive KBA exercise according to the designed sessions for 8 weeks in addition to the conventional therapy. All groups will be assessed pre-intervention, immediately post-intervention and at 8 weeks, 3-month, 4-month, and 6-month post-randomization. The primary outcome will be physical function (Ibadan Knee and Hip Osteoarthritis Outcome Measure) while the secondary outcomes will be pain (Visual Analogue Scale for pain), knee stability (Knee Outcome Survey-Activities of Daily Living Scale), proprioception (electronic goniometer), and quality of life (Osteoarthritis Knee and Hip Quality of Life Questionnaire).Discussion: Findings of this study may provide evidence on the effectiveness of KBA exercise and the ideal number of sessions needed to achieve the highest effectiveness in adults with knee OA.Trial registration: Pan African Clinical Trials Registry, (PACTR201810713260138), Retrospectively registered on 28 November 2017.

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Intra-Articular Hybrid Hyaluronic Acid Injection Treatment in Overweight Patients with Knee Osteoarthritis: A Single-Center, Open-Label, Prospective Study

Applied Sciences ◽

10.3390/app11188711 ◽

2021 ◽

Vol 11 (18) ◽

pp. 8711

Author(s):

Dalila Scaturro ◽

Fabio Vitagliani ◽

Pietro Terrana ◽

Daniele Cuntrera ◽

Vincenzo Falco ◽

...

Keyword(s):

Quality Of Life ◽

Hyaluronic Acid ◽

Knee Osteoarthritis ◽

Disease Severity ◽

Prospective Trial ◽

Open Label ◽

Knee Oa ◽

Symptomatic Knee ◽

Significant Difference

Background: A BMI > 25 is the most decisive, albeit modifiable, risk factor for knee osteoarthritis (KOA). This study aimed at assessing the efficacy of intra-articular injections of hybrid hyaluronic acid (HA) complexes (Sinovial® H-L) for the treatment of KOA in overweight patients in terms of disease severity, cardiocirculatory capacity, and quality of life. Materials: In this single-site, open-label, prospective trial, 37 patients with symptomatic knee OA were assessed at baseline and 3 months after ultrasound-guided intra-articular injection of hybrid HA complexes (Sinovial® H-L). Results: Primary variables displaying a statistically significant improvement after treatment were pain (VAS), disease severity (WOMAC), and cardiopulmonary capacity (6 min walk test). Among secondary variables, quality of life (SF-12) improved significantly, as did analgesic intake for pain control. No statistically significant difference was observed in body fat and muscle mass percentage measured by bioelectrical impedance analysis. Conclusions: Intra-articular hybrid HA injections are significantly effective in improving OA-related disease severity, cardiopulmonary function, and analgesic intake. This supports the role of hybrid HA viscosupplementation as a nonpharmacological treatment to relieve pain, reduce disability, improve quality of life, and limit the risk of polypharmacy in overweight patients with knee OA.

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The role of electrotherapy in reducing the pain of patients with knee osteoarthritis during the COVID-19 pandemic

Balneo Research Journal ◽

10.12680/balneo.2020.390 ◽

2020 ◽

pp. 512-515

Author(s):

Elisabeta ANTONESCU ◽

Sînziana Călina SILIŞTEANU ◽

Maria TOTAN

Keyword(s):

Quality Of Life ◽

Knee Osteoarthritis ◽

Age Groups ◽

Pain Syndrome ◽

Painful Symptom ◽

Gender And Age ◽

Physical Dysfunction ◽

Recovery Treatment

Introduction. Osteoarthritis is considered to be the most common form of arthritis and a leading disability cause worldwide, especially due to the painful symptom. The latter is a clinical marker in evaluating the limits of joint mobility and therefore, the pain reduction is a goal of the recovery treatment for patients with knee osteoarthritis. The purpose of this study was to show whether the pain phenomenon characteristic of knee osteoarthritis can be reduced by electrotherapy, even in the context of the COVID-19 pandemic. Material and method. The study lasted 5 months and included 171 patients diagnosed clinically and radiologically with knee osteoarthritis. The followed parameters were pain, physical dysfunction in daily activities, anxiety and quality of life. Results and discussions. The two groups of studied patients were homogeneous in terms of weight by gender and age groups. The evaluation of patients according to scales enabled the registration of statistically significant values, the value of p <0.05, which explains the validation of the working hypothesis. The feeling of pain is closely related to the level of anxiety. Conclusions. Analgesic electrotherapy significantly reduced the pain syndrome of the patients for whom it was used. It has been shown that the patients' anxiety can influence the pain phenomenon. Given the conditions caused by the Covid-19 pandemic, the anxiety of the patients who were in the outpatient department to receive recovery treatment was increased, but after the recovery treatment there was a decrease, so these patients' quality of life increased. Keywords: pain, analgesic electrotherapy, knee osteoarthritis, recovery treatment,

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Effects of weight change and physical activity on knee pain and health-related quality of life in East Asian women aged 50 years and older with knee osteoarthritis: a population-based study

10.21203/rs.2.11017/v1 ◽

2019 ◽

Author(s):

Young Choi ◽

Chongbum Chang ◽

Seung-Baik Kang ◽

Chin Youb Chung ◽

Moon Seok Park ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Knee Osteoarthritis ◽

Knee Pain ◽

Weight Change ◽

Population Based ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Abstract Objective This study aimed to investigate the effects of weight change and physical activity on the level of knee pain and health-related quality of life in East Asian women with knee osteoarthritis using population-based data. Methods A total of 564 women (mean age, 68.2 years, standard deviation, 8.9 years) aged 50 years or older with knee osteoarthritis (Kellgren-Lawrence grade ≥2) were included in the data analyses from the fifth Korea National Health and Nutrition Examination Survey. Data regarding the radiographic grade, weight change during the past year, physical activity, level of knee pain, and health-related quality of life (EuroQOL five-dimension [EQ-5D] index) were collected. Multiple regression analysis was performed to identify factors significantly affecting the level of knee pain and health-related quality of life in subgroups according to the body mass index (BMI) range (≤22.5, between 22.6 and 27.5, and >27.5 kg/m2). Results In women with 22.5 kg/m227.5 kg/m2, weekly hours of moderate-intensity activity showed significant negative correlation with EQ-5D. Conclusions The effects of weight change and physical activity on knee pain and health-related quality of life could be different according to BMI ranges. Well-designed interventions to improve both knee pain and health-related quality of life need to be investigated in future studies that would assess physical activity, diet, and weight changes.

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The Effectiveness of Intra-Articular Injection of Hypertonic Saline in Pain Control and Function of Patients with Knee Osteoarthritis

Journal of Orthopedic and Spine Trauma ◽

10.18502/jost.v5i1.3320 ◽

2020 ◽

Author(s):

Behrouz Tavana ◽

Sirous Azizi ◽

Sharif Najafi ◽

Ensie Taftian ◽

Nastaran Maghbouli

Keyword(s):

Quality Of Life ◽

Knee Osteoarthritis ◽

Hypertonic Saline ◽

Pain Reduction ◽

Functional Improvement ◽

Obese Patients ◽

Knee Oa ◽

Vas Score ◽

American College Of Rheumatology

Background: The aim of this study was to report the effectiveness of intra-articular injection of hypertonic saline in pain reduction and functional improvement in patients with knee osteoarthritis (OA). Methods: Patients with knee pain and dysfunction who fulfilled the American College of Rheumatology criteria and whose illness was sub-acute or chronic were enrolled. We performed a single intra-articular injection of 5 cc of hypertonic (5%) saline solution. Measured outcomes were Visual Analogue Scale (VAS) score and Knee Injury and Osteoarthritis Outcome Score (KOOS) evaluated before and 1 month after intervention. Results: A total of 28 patients with mean age of 66.3 years were surveyed. Overall, study participants reported clinically and statistically significant reduction in VAS and KOOS subscales for symptoms, pain, function, daily living, sports, recreational activities, and quality of life in one month of follow-up with respect to the patients’ mean baseline scores (by 24.47%, 42.74%, 54.96%, 43.78%, and 63.63%, respectively). Although obese patients [body mass index (BMI) ≥ 30 kg/m2] showed less improvement in terms of pain, sports, and quality of life subscales of KOOS, compared with non-obese patients (BMI < 30 kg/m2); VAS score difference was not significant. Conclusion: Intra-articular injection of hypertonic saline yields a statistically and clinically significant short-term pain reduction and functional improvement of patients with knee OA.

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