scholarly journals A Presentation of a Case of Hb E Homozygosity

Author(s):  
Mohamed Samir M Khalil
Keyword(s):  
2018 ◽  
Vol 2 (02) ◽  
pp. 39-41
Author(s):  
Md. Rafiquzzaman Khan ◽  
Arifur Rahman ◽  
Khaza Amirul Islam ◽  
AQM Ashraful Haque ◽  
Masuda Begum

The aim of this retrospective observational study was to observe the pattern and frequency of haematological disorders among the patients attending in the specialized Haematology outpatient Department (HOPD) in Bangabandhu Sheikh Mujib Medical University. Consecutive 201 patients over the period of one year were enrolled. Their age ranged from 01 to 72 years with a mean age of 36.76 years. Most of the patients (34.3%) were in between the ages of 31 to 45 years followed by 16 to 30 years (27.9%). Male to female ratio was 0.65. Iron deficiency anaemia is the most common (24.9%) followed by chronic myeloid leukaemia (11.9%), Hb E beta thalassaemia (9.5%), idiopathic thrombocytopenic purpura (9.5%), beta thalassaemia trait (7.0%), Hb E trait (5.5 %), aplastic anaemia (5.0%), multiple myeloma (3.5%), acute lymphoblastic leukaemia (3.0%). Acute myeloid leukaemia, autoimmune haemolytic anaemia, chronic lymphocytic leukaemia, anaemia of chronic disease, non-Hodgkin lymphoma, polycythaemia, beta thalassemia major and alpha thalassemia was 2.5%, 2.5%, 2.0%, 1.5%, 1.5%, 1.5%, 1.0% and 1.0%, respectively. In the present study, we observed that iron deficiency anaemia the most common non-malignant disease and chronic myeloid leukaemia is the common haematological malignancy.


Author(s):  
Li Chen ◽  
Linhui Liang ◽  
Shuzhen Liao ◽  
Yan Huang ◽  
Liang Liang ◽  
...  
Keyword(s):  
Hb E ◽  

2005 ◽  
Vol 1054 (1) ◽  
pp. 433-438 ◽  
Author(s):  
ORAPAN SRIPICHAI ◽  
JOHANNA WHITACRE ◽  
THONGPERM MUNKONGDEE ◽  
CHUTIMA KUMKHAEK ◽  
WATTANAN MAKARASARA ◽  
...  
Keyword(s):  

Author(s):  
Suneerat Hatairaktham ◽  
Patarabutr Masaratana ◽  
Chattree Hantaweepant ◽  
Chatchawan Srisawat ◽  
Vorapan Sirivatanauksorn ◽  
...  
Keyword(s):  

2014 ◽  
Vol 6 (1) ◽  
pp. e2014060 ◽  
Author(s):  
R S Balgir

Background: Red cell inherited hemoglobin anomalies are commonly encountered in the central region of India. These cause a public health concern due to high degree of morbidity, mortality, and fetal loss in the backward, underprivileged, and vulnerable people. Purpose: To report five typical families of hemoglobin E disorders identified for the first time in the state of Madhya Pradesh from central India. Methods: Out of a total of 445 couples/families (excluding the present study) with 1526 persons (848 males and 678 females) referred from a tertiary hospital in central India for investigations of anemia/hemoglobinopathies during the period from March 2010 to February 2014, we came across five typical rare couples/families of hemoglobin E disorders worthy of detailed investigations. Laboratory investigations were carried out following the standard procedures after cross checking for quality control from time to time. Results: For the first time, we have encountered nine cases of heterozygous hemoglobin E trait, two members with hemoglobin E-β-thalassemia (double heterozygosity), two cases of sickle cell-hemoglobin E disease (double heterozygosity), and none with homozygous hemoglobin E. Cases  of hemoglobin E trait, hemoglobin E-β-thalassemia, sickle cell-β-thalassemia and sickle cell-E disease showed moderate to severe anemia, and target cells, and reduced values of red cell indices like RBC, Hb level, HCT, MCV, MCH and MCHC, representing abnormal hematological profile and clinical manifestations before blood transfusion. Conclusions: Double heterozygosity for hemoglobinopathies such as occurrence of β-thalassemia mutation with structurally abnormal hemoglobins (Hb S and Hb E) is a rare entity, but occurs with severe clinical manifestations only in those areas or communities where these are highly prevalent, testifying the migrations and genetic admixture. Distribution of hemoglobin E and β-thalassemia in different districts of Madhya Pradesh indicates that abnormal Hb E gene has wide spread and needs prevention for the rehabilitation of vulnerable people in central India. 


1993 ◽  
Vol 49 (1) ◽  
pp. 67-73 ◽  
Author(s):  
F.W. Lorey ◽  
G.C. Cunningham ◽  
E. Vichinsky ◽  
B. Lubin ◽  
F. Shafer ◽  
...  

2019 ◽  
Vol 36 (1) ◽  
pp. 123-128
Author(s):  
Siddhesh Arun Kalantri ◽  
Rudra Ray ◽  
Soumita Choudhuri ◽  
Swarnalata Roy ◽  
Maitreyee Bhattacharyya

2020 ◽  
Vol 7 (9) ◽  
pp. 1423
Author(s):  
Shobhit Goel ◽  
Preeti Tripathi ◽  
Arijit Sen ◽  
Sangeetha Sampath

Glycosylated hemoglobin (HbA1C) is a routinely measured parameter to monitor long term glycemic control in patients with diabetes mellitus. There are many potential interferents which can affect measurement of HbA1C by high performance liquid chromatography (HPLC). Variant hemoglobins, especially, are a common source of confusion and errors in HbA1C measurement. Authors present an interesting case of Hb E variant (undiagnosed hitherto) which came to attention when the machine repeatedly failed to give Hb A1C levels. Hb E is the commonest Hb variant in North East India. In the presence of Hb E, HbA1C may not be detected by ion exchange chromatography as both hemoglobin’s co- elute together, thereby causing errors. In such cases, the clinician may resort to subcutaneous sugar monitoring as an alternate or if required, Hb A1C measurement may be done by other techniques like immunoassay technique or boronated affinity chromatography. The laboratory staff and clinicians, both, should be aware of this limitation of HbA1C estimation in patients with HbE and other Hb variants.


Hemoglobin ◽  
2012 ◽  
Vol 37 (1) ◽  
pp. 26-36 ◽  
Author(s):  
Deboshree Bhattacharyya ◽  
Ashis Mukhopadhyay ◽  
Abhijit Chakraborty ◽  
Swati Dasgupta ◽  
Soma Mukhopadhyay ◽  
...  
Keyword(s):  

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